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- W2809503383 abstract "During the last two decades front-line treatment of metastatic Non Small Cell Lung Cancer (NSCLC) has profoundly changed moving from the old one size fits all concept to a histology-based approach and then, for a small subgroup of patients to a molecularly-selected one. The development of immune checkpoint inhibitors and the unprecedented results reported in 2nd/3rd line prompted the evaluation of these novel therapeutic agents in chemotherapy-naïve patients either alone or in combination with platinum-based chemotherapy. Several randomized trials are evaluating the impact of immune-checkpoint inhibitors in 1st line and some of them have yet produced preliminary evidence of efficacy. However, still a long way to go and several questions are still unanswered, including proper patients selection, optimal sequential/combinatorial use of these agents, appropriate treatment duration, and finally the identification of predictive biomarkers. The aim of this paper is to provide a comprehensive overview on the growing role of immune checkpoint inhibitors in the upfront treatment of advanced non-oncogene addicted NSCLC either as single agent or in combination with other agents." @default.
- W2809503383 created "2018-06-29" @default.
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- W2809503383 date "2018-10-01" @default.
- W2809503383 modified "2023-09-27" @default.
- W2809503383 title "The changing scenario of 1st line therapy in non-oncogene addicted NSCLCs in the era of immunotherapy" @default.
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- W2809503383 doi "https://doi.org/10.1016/j.critrevonc.2018.06.007" @default.
- W2809503383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30196906" @default.
- W2809503383 hasPublicationYear "2018" @default.
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