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- W2809585987 abstract "Parkinson disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer disease, characterized by loss of dopaminergic neurons in substantia nigra pars compacta, accompanied by motor and non-motor symptoms. Idiopathic PD is the most common cause of Parkinsonism (primary Parkinsonism) while, certain medication and different groups of neurological disorder may be causes of secondary Parkinsonism. The presence of intraneuronal proteinaceous cytoplasmic inclusions “Lewy Bodies” and the loss of the nigrostriatal dopaminergic neurons are the main neuropathological hallmarks of PD. However, the etiology of the disease is still undefined; several studies assume that oxidative stress, mitochondrial defects, neuroinflammation, apoptosis and excitotoxicity play vital roles in the pathogenesis and progress of the disease. Experimental models of PD can be induced by several neurotoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 6-hydroxydopamine, rotenone and paraquat which produce neuropathological and neurochemical changes that are identical to those seen in PD. The primary drug for PD treatment is L-dopa; however, drug-induced dyskinesia and motor complications restricted its use as long term treatment. Dopamine agonists are alternative options for initial treatment of PD and have been reported to retard the onset of motor complications. Combination of L-dopa with other medications, such ascatechol-O-methyltransferase inhibitors and monoamine oxidase B inhibitors has the ability to alleviate L-dopa-induced motor complications. Anticholinergic drugs can be used to control the symptoms of PD but their cognitive and autonomic side effects make them unsuitable for the elderly." @default.
- W2809585987 created "2018-06-29" @default.
- W2809585987 creator A5050131288 @default.
- W2809585987 creator A5053776675 @default.
- W2809585987 creator A5067817879 @default.
- W2809585987 creator A5079100642 @default.
- W2809585987 date "2018-06-12" @default.
- W2809585987 modified "2023-09-23" @default.
- W2809585987 title "Parkinson's disease: A Review about Pathogenesis, Pharmaceutical Treatment and Experimental Models" @default.
- W2809585987 cites W1059798 @default.
- W2809585987 cites W1066238792 @default.
- W2809585987 cites W1440913109 @default.
- W2809585987 cites W1487894289 @default.
- W2809585987 cites W1504584187 @default.
- W2809585987 cites W1510211954 @default.
- W2809585987 cites W1518185094 @default.
- W2809585987 cites W1522510037 @default.
- W2809585987 cites W1530199299 @default.
- W2809585987 cites W1540436551 @default.
- W2809585987 cites W1545786314 @default.
- W2809585987 cites W1559663349 @default.
- W2809585987 cites W1568165441 @default.
- W2809585987 cites W1582304017 @default.
- W2809585987 cites W1591724033 @default.
- W2809585987 cites W1597483344 @default.
- W2809585987 cites W1676879554 @default.
- W2809585987 cites W1891759263 @default.
- W2809585987 cites W1954514489 @default.
- W2809585987 cites W1960100142 @default.
- W2809585987 cites W1965006448 @default.
- W2809585987 cites W1965697123 @default.
- W2809585987 cites W1969800514 @default.
- W2809585987 cites W1976749972 @default.
- W2809585987 cites W1979193480 @default.
- W2809585987 cites W1981269355 @default.
- W2809585987 cites W1982060705 @default.
- W2809585987 cites W1982666490 @default.
- W2809585987 cites W1987655773 @default.
- W2809585987 cites W1988173316 @default.
- W2809585987 cites W1989350751 @default.
- W2809585987 cites W1991865867 @default.
- W2809585987 cites W1991939322 @default.
- W2809585987 cites W1992321824 @default.
- W2809585987 cites W1995601854 @default.
- W2809585987 cites W1998987489 @default.
- W2809585987 cites W1999595382 @default.
- W2809585987 cites W2000604066 @default.
- W2809585987 cites W2000993232 @default.
- W2809585987 cites W2002559713 @default.
- W2809585987 cites W2002784780 @default.
- W2809585987 cites W2003760823 @default.
- W2809585987 cites W2004349171 @default.
- W2809585987 cites W2007360321 @default.
- W2809585987 cites W2007635429 @default.
- W2809585987 cites W2007751663 @default.
- W2809585987 cites W2007858325 @default.
- W2809585987 cites W2008827081 @default.
- W2809585987 cites W2012363426 @default.
- W2809585987 cites W2012376614 @default.
- W2809585987 cites W2017083493 @default.
- W2809585987 cites W2019687738 @default.
- W2809585987 cites W2021620432 @default.
- W2809585987 cites W2024943443 @default.
- W2809585987 cites W2025208649 @default.
- W2809585987 cites W2029246446 @default.
- W2809585987 cites W2031172417 @default.
- W2809585987 cites W2032730800 @default.
- W2809585987 cites W2033537576 @default.
- W2809585987 cites W2033705417 @default.
- W2809585987 cites W2034909646 @default.
- W2809585987 cites W2035769824 @default.
- W2809585987 cites W2035793032 @default.
- W2809585987 cites W2036385867 @default.
- W2809585987 cites W2039564595 @default.
- W2809585987 cites W2043899667 @default.
- W2809585987 cites W2044074582 @default.
- W2809585987 cites W2044384631 @default.
- W2809585987 cites W2047670437 @default.
- W2809585987 cites W2048033372 @default.
- W2809585987 cites W2048570076 @default.
- W2809585987 cites W2049359499 @default.
- W2809585987 cites W2050279035 @default.
- W2809585987 cites W2050643060 @default.
- W2809585987 cites W2053184316 @default.
- W2809585987 cites W2056831293 @default.
- W2809585987 cites W2059243765 @default.
- W2809585987 cites W2061728401 @default.
- W2809585987 cites W2061995199 @default.
- W2809585987 cites W2062605045 @default.
- W2809585987 cites W2068269301 @default.
- W2809585987 cites W2070187172 @default.
- W2809585987 cites W2071736632 @default.
- W2809585987 cites W2072731831 @default.
- W2809585987 cites W2072942101 @default.
- W2809585987 cites W2073351779 @default.
- W2809585987 cites W2074112508 @default.
- W2809585987 cites W2074472723 @default.
- W2809585987 cites W2079536916 @default.
- W2809585987 cites W2083334071 @default.
- W2809585987 cites W2086787317 @default.