Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809598607> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2809598607 endingPage "P" @default.
- W2809598607 startingPage "1265" @default.
- W2809598607 abstract "Management of type 2 diabetes (T2D) needs different treatment strategies to achieve the individualized glycemic goal. This study evaluated the long-term cost effectiveness of strategies involving pathway 1: metformin followed by intensification with dipeptidyl peptidase-4 inhibitors (DPP-4i), sodium-glucose co-transporter 2 inhibitors (SGLT2i) and insulin vs. pathway 2: metformin followed by intensification with sulfonylurea (SU) and insulin in the U.S. Cost-effectiveness analysis was performed using the validated QuintilesIMS CORE Diabetes Model from a U.S. payer perspective. Clinical and economic outcomes were modeled over a lifetime for a cohort of T2D patients who fail to achieve glycemic goal on metformin monotherapy. Clinical data were obtained from clinical trials. Direct medical costs [e.g., medications (whole sale acquisition costs), diabetes management, adverse events, and complications] were obtained from published sources. Despite higher direct medical costs for pathway 1 compared to pathway 2 ($117,779 vs. $93,196 respectively); pathway 1 improved total quality-adjusted life years (QALY) by 0.28 vs. pathway 2. Pathway 1 also led to cost offsets from fewer diabetes-related complications and delayed initiation of insulin. The incremental cost-effectiveness ratio (ICER) was favorable for pathway 1 at $89,038/QALY. Most of the scenario analysis (changes in treatment effect, hypoglycemia, and cardiovascular protective effects of SGLT2is) resulted in ICERs under $100,000/QALY except for the population with baseline HbA1c of 7%, and older age (65+ years). Negotiated discounts on branded medications resulted in significant improvement in ICERs (ICER of $69,554/QALY for 15% discount and $0/QALY for 75% discount). Among patients failing metformin monotherapy in the U.S, additional intensification with DPP-4i followed by SGLT2i may be considered more cost effective compared to intensification with SU followed by insulin." @default.
- W2809598607 created "2018-06-29" @default.
- W2809598607 creator A5042052676 @default.
- W2809598607 creator A5058591494 @default.
- W2809598607 creator A5061221279 @default.
- W2809598607 creator A5067407951 @default.
- W2809598607 creator A5073303158 @default.
- W2809598607 creator A5091743333 @default.
- W2809598607 date "2018-06-22" @default.
- W2809598607 modified "2023-09-26" @default.
- W2809598607 title "Cost Effectiveness of DPP-4i and SGLT2i Combination Therapy for the Treatment of Type 2 Diabetes in the U.S." @default.
- W2809598607 doi "https://doi.org/10.2337/db18-1265-p" @default.
- W2809598607 hasPublicationYear "2018" @default.
- W2809598607 type Work @default.
- W2809598607 sameAs 2809598607 @default.
- W2809598607 citedByCount "0" @default.
- W2809598607 crossrefType "journal-article" @default.
- W2809598607 hasAuthorship W2809598607A5042052676 @default.
- W2809598607 hasAuthorship W2809598607A5058591494 @default.
- W2809598607 hasAuthorship W2809598607A5061221279 @default.
- W2809598607 hasAuthorship W2809598607A5067407951 @default.
- W2809598607 hasAuthorship W2809598607A5073303158 @default.
- W2809598607 hasAuthorship W2809598607A5091743333 @default.
- W2809598607 hasConcept C112930515 @default.
- W2809598607 hasConcept C126322002 @default.
- W2809598607 hasConcept C134018914 @default.
- W2809598607 hasConcept C197934379 @default.
- W2809598607 hasConcept C2777180221 @default.
- W2809598607 hasConcept C2778854520 @default.
- W2809598607 hasConcept C2779306644 @default.
- W2809598607 hasConcept C2779900020 @default.
- W2809598607 hasConcept C2780323712 @default.
- W2809598607 hasConcept C2780473172 @default.
- W2809598607 hasConcept C2780668416 @default.
- W2809598607 hasConcept C2908647359 @default.
- W2809598607 hasConcept C2910068830 @default.
- W2809598607 hasConcept C3019080777 @default.
- W2809598607 hasConcept C555293320 @default.
- W2809598607 hasConcept C64332521 @default.
- W2809598607 hasConcept C71924100 @default.
- W2809598607 hasConcept C99454951 @default.
- W2809598607 hasConceptScore W2809598607C112930515 @default.
- W2809598607 hasConceptScore W2809598607C126322002 @default.
- W2809598607 hasConceptScore W2809598607C134018914 @default.
- W2809598607 hasConceptScore W2809598607C197934379 @default.
- W2809598607 hasConceptScore W2809598607C2777180221 @default.
- W2809598607 hasConceptScore W2809598607C2778854520 @default.
- W2809598607 hasConceptScore W2809598607C2779306644 @default.
- W2809598607 hasConceptScore W2809598607C2779900020 @default.
- W2809598607 hasConceptScore W2809598607C2780323712 @default.
- W2809598607 hasConceptScore W2809598607C2780473172 @default.
- W2809598607 hasConceptScore W2809598607C2780668416 @default.
- W2809598607 hasConceptScore W2809598607C2908647359 @default.
- W2809598607 hasConceptScore W2809598607C2910068830 @default.
- W2809598607 hasConceptScore W2809598607C3019080777 @default.
- W2809598607 hasConceptScore W2809598607C555293320 @default.
- W2809598607 hasConceptScore W2809598607C64332521 @default.
- W2809598607 hasConceptScore W2809598607C71924100 @default.
- W2809598607 hasConceptScore W2809598607C99454951 @default.
- W2809598607 hasIssue "Supplement 1" @default.
- W2809598607 hasLocation W28095986071 @default.
- W2809598607 hasOpenAccess W2809598607 @default.
- W2809598607 hasPrimaryLocation W28095986071 @default.
- W2809598607 hasRelatedWork W1738698853 @default.
- W2809598607 hasRelatedWork W1975302648 @default.
- W2809598607 hasRelatedWork W1996441843 @default.
- W2809598607 hasRelatedWork W2083441169 @default.
- W2809598607 hasRelatedWork W2152219724 @default.
- W2809598607 hasRelatedWork W2335096023 @default.
- W2809598607 hasRelatedWork W2589309406 @default.
- W2809598607 hasRelatedWork W2761179810 @default.
- W2809598607 hasRelatedWork W2765236233 @default.
- W2809598607 hasRelatedWork W4287108513 @default.
- W2809598607 hasVolume "67" @default.
- W2809598607 isParatext "false" @default.
- W2809598607 isRetracted "false" @default.
- W2809598607 magId "2809598607" @default.
- W2809598607 workType "article" @default.