Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809600233> ?p ?o ?g. }
- W2809600233 abstract "Epilepsy is a common neurological disease with recurrent seizures and neurobehavioral comorbidities, including cognitive impairment and psychiatric disorders.Recent studies suggest that L-3-n-butylphthalide (NBP), an extract from the seeds of Apiumgraveolens Linn (Chinese celery), ameliorates cognitive dysfunction in ischemia and/or Alzheimer's disease (AD) animal models. However, little is known about the role of NBP in epilepsy and the associated comorbidities. Here, using a pilocarpine-induced chronic epileptic mouse model, we found that NBP supplement not only alleviated seizure severity and abnormal electroencephalogram (EEG), but also rescued cognitive and emotional impairments in these epileptic mice.The possible underlying mechanisms may be associated with theprotective role of NBP in reducing neuronal loss and in restoring the expression of neural synaptic proteins such as postsynaptic density protein 95 (PSD95) and glutamic acid decarboxylase 65/67 (GAD65/67). In addition, NBP treatment increased the transcription of neuroprotective factors, brain-derived neurotrophic factor (BDNF) and Klotho.These findings suggest that NBP treatment may be a potential strategy for ameliorating epileptogenesis and the comorbidities of cognitive and psychological impairments." @default.
- W2809600233 created "2018-06-29" @default.
- W2809600233 creator A5014669662 @default.
- W2809600233 creator A5016640593 @default.
- W2809600233 creator A5018805220 @default.
- W2809600233 creator A5036677628 @default.
- W2809600233 creator A5043869758 @default.
- W2809600233 creator A5053032258 @default.
- W2809600233 creator A5060214423 @default.
- W2809600233 creator A5061026904 @default.
- W2809600233 creator A5068242622 @default.
- W2809600233 creator A5080115213 @default.
- W2809600233 creator A5082921381 @default.
- W2809600233 creator A5089675292 @default.
- W2809600233 creator A5091731062 @default.
- W2809600233 date "2018-07-11" @default.
- W2809600233 modified "2023-10-13" @default.
- W2809600233 title "Protective Role of L-3-n-Butylphthalide in Cognitive Function and Dysthymic Disorders in Mouse With Chronic Epilepsy" @default.
- W2809600233 cites W1445672438 @default.
- W2809600233 cites W1487695731 @default.
- W2809600233 cites W1603774123 @default.
- W2809600233 cites W1604457499 @default.
- W2809600233 cites W1624178692 @default.
- W2809600233 cites W1879074807 @default.
- W2809600233 cites W1892055067 @default.
- W2809600233 cites W1911620167 @default.
- W2809600233 cites W1914011667 @default.
- W2809600233 cites W1922973595 @default.
- W2809600233 cites W1973539125 @default.
- W2809600233 cites W1974809694 @default.
- W2809600233 cites W1984025514 @default.
- W2809600233 cites W1985394452 @default.
- W2809600233 cites W1988869895 @default.
- W2809600233 cites W1997901204 @default.
- W2809600233 cites W2000209446 @default.
- W2809600233 cites W2004654171 @default.
- W2809600233 cites W2011965698 @default.
- W2809600233 cites W2015445848 @default.
- W2809600233 cites W2019265023 @default.
- W2809600233 cites W2020889306 @default.
- W2809600233 cites W2025495248 @default.
- W2809600233 cites W2034380892 @default.
- W2809600233 cites W2041016831 @default.
- W2809600233 cites W2041555129 @default.
- W2809600233 cites W2055357706 @default.
- W2809600233 cites W2065401361 @default.
- W2809600233 cites W2068110537 @default.
- W2809600233 cites W2068910138 @default.
- W2809600233 cites W2072072353 @default.
- W2809600233 cites W2075088231 @default.
- W2809600233 cites W2080335818 @default.
- W2809600233 cites W2082411508 @default.
- W2809600233 cites W2096500024 @default.
- W2809600233 cites W2103946141 @default.
- W2809600233 cites W2105179195 @default.
- W2809600233 cites W2107411150 @default.
- W2809600233 cites W2110905221 @default.
- W2809600233 cites W2123094571 @default.
- W2809600233 cites W2124852494 @default.
- W2809600233 cites W2125476206 @default.
- W2809600233 cites W2135042689 @default.
- W2809600233 cites W2152326266 @default.
- W2809600233 cites W2161986963 @default.
- W2809600233 cites W2169473035 @default.
- W2809600233 cites W2215939331 @default.
- W2809600233 cites W2265291900 @default.
- W2809600233 cites W2345526058 @default.
- W2809600233 cites W2355309071 @default.
- W2809600233 cites W2367812079 @default.
- W2809600233 cites W2397082620 @default.
- W2809600233 cites W2460073250 @default.
- W2809600233 cites W2480068582 @default.
- W2809600233 cites W2554548393 @default.
- W2809600233 cites W2563036039 @default.
- W2809600233 cites W2735697144 @default.
- W2809600233 cites W2765527865 @default.
- W2809600233 cites W2766534640 @default.
- W2809600233 cites W2766594096 @default.
- W2809600233 cites W2780849204 @default.
- W2809600233 cites W2792856466 @default.
- W2809600233 cites W2793579479 @default.
- W2809600233 cites W2794356169 @default.
- W2809600233 cites W4285719527 @default.
- W2809600233 cites W4317434890 @default.
- W2809600233 cites W62288012 @default.
- W2809600233 cites W70680850 @default.
- W2809600233 doi "https://doi.org/10.3389/fphar.2018.00734" @default.
- W2809600233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6051017" @default.
- W2809600233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30050437" @default.
- W2809600233 hasPublicationYear "2018" @default.
- W2809600233 type Work @default.
- W2809600233 sameAs 2809600233 @default.
- W2809600233 citedByCount "16" @default.
- W2809600233 countsByYear W28096002332019 @default.
- W2809600233 countsByYear W28096002332020 @default.
- W2809600233 countsByYear W28096002332021 @default.
- W2809600233 countsByYear W28096002332022 @default.
- W2809600233 countsByYear W28096002332023 @default.
- W2809600233 crossrefType "journal-article" @default.
- W2809600233 hasAuthorship W2809600233A5014669662 @default.