Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809615908> ?p ?o ?g. }
- W2809615908 endingPage "61" @default.
- W2809615908 startingPage "54" @default.
- W2809615908 abstract "Groundwater arsenic contamination has become a serious global concern due to its adverse effects on human health. Arsenic-induced reactive oxygen species trigger oxidative stress inside mitochondria, which initiate a cascade of events including altered mitochondrial (mt) membrane potential, uncoupling of electron transport chain, and mtDNA damage. A case-control study was conducted to examine the association between arsenic exposure and differences in mtDNA methylation and to assess the downstream consequences. We recruited 221 arsenic-exposed individuals, including 106 individuals with skin lesions (WSL) and 115 subjects without any skin lesions (WOSL) from the Murshidabad district, West Bengal, India. The unexposed group included 101 individuals from the arsenic unexposed area in East Midnapore. We analyzed the status of mtDNA methylation in D-loop region and ND6 gene by methylation-specific PCR. Gene expression was studied by quantitative real-time PCR. Significant hypomethylation in both D-loop and ND6 was observed with a consequent increase in their target gene expression and higher mtDNA copy number in arsenic-exposed populations compared to controls. Further mechanistic insights regarding mitochondrial epigenetic alteration in arsenic exposure will be of critical importance for the prevention of adverse health effects." @default.
- W2809615908 created "2018-06-29" @default.
- W2809615908 creator A5016779049 @default.
- W2809615908 creator A5059064363 @default.
- W2809615908 creator A5075478425 @default.
- W2809615908 date "2018-09-01" @default.
- W2809615908 modified "2023-10-17" @default.
- W2809615908 title "Hypomethylation of mitochondrial D-loop and ND6 with increased mitochondrial DNA copy number in the arsenic-exposed population" @default.
- W2809615908 cites W1567033635 @default.
- W2809615908 cites W1799046027 @default.
- W2809615908 cites W1955649014 @default.
- W2809615908 cites W1963558685 @default.
- W2809615908 cites W1980764234 @default.
- W2809615908 cites W1996319492 @default.
- W2809615908 cites W2010693203 @default.
- W2809615908 cites W2012881604 @default.
- W2809615908 cites W2027307634 @default.
- W2809615908 cites W2028537695 @default.
- W2809615908 cites W2039200890 @default.
- W2809615908 cites W2040455470 @default.
- W2809615908 cites W2053222738 @default.
- W2809615908 cites W2053621737 @default.
- W2809615908 cites W2060242635 @default.
- W2809615908 cites W2071051119 @default.
- W2809615908 cites W2076950775 @default.
- W2809615908 cites W2087529306 @default.
- W2809615908 cites W2097286561 @default.
- W2809615908 cites W2104177319 @default.
- W2809615908 cites W2106592077 @default.
- W2809615908 cites W2109291482 @default.
- W2809615908 cites W2113654409 @default.
- W2809615908 cites W2117528386 @default.
- W2809615908 cites W2129976732 @default.
- W2809615908 cites W2137983089 @default.
- W2809615908 cites W2140126848 @default.
- W2809615908 cites W2150095915 @default.
- W2809615908 cites W2153375305 @default.
- W2809615908 cites W2157896268 @default.
- W2809615908 cites W2159479663 @default.
- W2809615908 cites W2162789670 @default.
- W2809615908 cites W2173698021 @default.
- W2809615908 cites W2184618836 @default.
- W2809615908 cites W2186860642 @default.
- W2809615908 cites W2225347805 @default.
- W2809615908 cites W2230121964 @default.
- W2809615908 cites W2309018700 @default.
- W2809615908 cites W2408790813 @default.
- W2809615908 cites W2511951145 @default.
- W2809615908 cites W2514600623 @default.
- W2809615908 cites W2549318896 @default.
- W2809615908 cites W2647395899 @default.
- W2809615908 cites W2770369035 @default.
- W2809615908 cites W2792719021 @default.
- W2809615908 cites W792457189 @default.
- W2809615908 doi "https://doi.org/10.1016/j.tox.2018.06.012" @default.
- W2809615908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29940200" @default.
- W2809615908 hasPublicationYear "2018" @default.
- W2809615908 type Work @default.
- W2809615908 sameAs 2809615908 @default.
- W2809615908 citedByCount "45" @default.
- W2809615908 countsByYear W28096159082019 @default.
- W2809615908 countsByYear W28096159082020 @default.
- W2809615908 countsByYear W28096159082021 @default.
- W2809615908 countsByYear W28096159082022 @default.
- W2809615908 countsByYear W28096159082023 @default.
- W2809615908 crossrefType "journal-article" @default.
- W2809615908 hasAuthorship W2809615908A5016779049 @default.
- W2809615908 hasAuthorship W2809615908A5059064363 @default.
- W2809615908 hasAuthorship W2809615908A5075478425 @default.
- W2809615908 hasConcept C104317684 @default.
- W2809615908 hasConcept C132165134 @default.
- W2809615908 hasConcept C150194340 @default.
- W2809615908 hasConcept C172507514 @default.
- W2809615908 hasConcept C178790620 @default.
- W2809615908 hasConcept C185592680 @default.
- W2809615908 hasConcept C190727270 @default.
- W2809615908 hasConcept C24586158 @default.
- W2809615908 hasConcept C28859421 @default.
- W2809615908 hasConcept C2908647359 @default.
- W2809615908 hasConcept C33288867 @default.
- W2809615908 hasConcept C41091548 @default.
- W2809615908 hasConcept C502230775 @default.
- W2809615908 hasConcept C54355233 @default.
- W2809615908 hasConcept C71924100 @default.
- W2809615908 hasConcept C86803240 @default.
- W2809615908 hasConcept C99454951 @default.
- W2809615908 hasConceptScore W2809615908C104317684 @default.
- W2809615908 hasConceptScore W2809615908C132165134 @default.
- W2809615908 hasConceptScore W2809615908C150194340 @default.
- W2809615908 hasConceptScore W2809615908C172507514 @default.
- W2809615908 hasConceptScore W2809615908C178790620 @default.
- W2809615908 hasConceptScore W2809615908C185592680 @default.
- W2809615908 hasConceptScore W2809615908C190727270 @default.
- W2809615908 hasConceptScore W2809615908C24586158 @default.
- W2809615908 hasConceptScore W2809615908C28859421 @default.
- W2809615908 hasConceptScore W2809615908C2908647359 @default.
- W2809615908 hasConceptScore W2809615908C33288867 @default.
- W2809615908 hasConceptScore W2809615908C41091548 @default.