FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809619862> ?p ?o ?g. }

• W2809619862 endingPage "e12871" @default.
• W2809619862 startingPage "e12871" @default.
• W2809619862 abstract "Prostaglandin E2 (PGE2) plays a critical role in intestinal mucosal tolerance and barrier integrity. Cyclooxygenase-2 (COX-2)-dependent PGE2 production involves mobilisation of arachidonic acid. Lactobacillus rhamnosus GG (LbGG) is one of the most widely used probiotics reported to colonise the colonic mucosa. LbGG contributes to the protection of the small intestine against radiation injury through the repositioning of mucosal COX-2 expressing cells. However, it is unknown if LbGG modulates PGE2 production in the colonic mucosa under homeostasis and the major cellular elements involved in these processes. Colonic epithelial and CD90+ mesenchymal stromal cells, also known as (myo) fibroblasts (CMFs), are abundant innate immune cells in normal colonic mucosa able to produce PGE2. Herein, we tested the hypothesis that under colonic mucosal homeostasis, LbGG modulates the eicosanoid pathway resulting in increased PGE2 production in both epithelial and stromal cells. Among the five tested human colonic epithelial cell lines, only exposure of Caco-2 to LbGG for 24 hr led to the mobilisation of arachidonic acid with concomitant increase in the components within the leukotriene and COX-2-dependent PGE2 pathways. By contrast, CMFs isolated from the normal human colonic mucosa responded to LbGG with increased expression of COX-2 and PGE2 in the prostaglandin pathway, but not 5-LO in the leukotriene pathway. Oral gavage of C57BL/6 mice for 5 days with LbGG (5 × 108 Colony-Forming Unit (CFU)/dose) increased COX-2 expression in the colonic mucosa. The majority of cells upregulating COX-2 protein expression were located in the colonic lamina propria and colocalised with α-SMA+ cells corresponding to the CMF phenotype. This process was myeloid differentiation factor-88-dependent, because silencing of myeloid differentiation factor-88 expression in CMFs abrogated LbGG-induced upregulation of COX-2 in culture and in vivo. Taken together, our data suggest that LbGG increases release of COX-2-mediated PGE2, contributing to the maintenance of mucosal homeostasis in the colon and CMFs are among the major contributors to this process." @default.
• W2809619862 created "2018-06-29" @default.
• W2809619862 creator A5008826006 @default.
• W2809619862 creator A5022402337 @default.
• W2809619862 creator A5034242696 @default.
• W2809619862 creator A5057298142 @default.
• W2809619862 creator A5057736103 @default.
• W2809619862 creator A5065938813 @default.
• W2809619862 creator A5077231158 @default.
• W2809619862 creator A5080597091 @default.
• W2809619862 creator A5080998067 @default.
• W2809619862 date "2018-07-26" @default.
• W2809619862 modified "2023-10-10" @default.
• W2809619862 title "<i>Lactobacillus rhamnosus</i>GG increases cyclooxygenase-2 expression and prostaglandin E2 secretion in colonic myofibroblasts via a MyD88-dependent mechanism during homeostasis" @default.
• W2809619862 cites W1552797663 @default.
• W2809619862 cites W1572204155 @default.
• W2809619862 cites W1785814390 @default.
• W2809619862 cites W1849012281 @default.
• W2809619862 cites W1940681873 @default.
• W2809619862 cites W1947705102 @default.
• W2809619862 cites W1949787703 @default.
• W2809619862 cites W1971402960 @default.
• W2809619862 cites W1973336678 @default.
• W2809619862 cites W1991805462 @default.
• W2809619862 cites W1996733510 @default.
• W2809619862 cites W1997781903 @default.
• W2809619862 cites W2003332982 @default.
• W2809619862 cites W2003509125 @default.
• W2809619862 cites W2006419403 @default.
• W2809619862 cites W2020639809 @default.
• W2809619862 cites W2038859574 @default.
• W2809619862 cites W2043460853 @default.
• W2809619862 cites W2051244361 @default.
• W2809619862 cites W2073686450 @default.
• W2809619862 cites W2077384146 @default.
• W2809619862 cites W2078191340 @default.
• W2809619862 cites W2079290729 @default.
• W2809619862 cites W2081521523 @default.
• W2809619862 cites W2082095075 @default.
• W2809619862 cites W2087377880 @default.
• W2809619862 cites W2095695756 @default.
• W2809619862 cites W2106729611 @default.
• W2809619862 cites W2107606668 @default.
• W2809619862 cites W2111727066 @default.
• W2809619862 cites W2115516793 @default.
• W2809619862 cites W2124364562 @default.
• W2809619862 cites W2133644846 @default.
• W2809619862 cites W2136703917 @default.
• W2809619862 cites W2145719229 @default.
• W2809619862 cites W2148439275 @default.
• W2809619862 cites W2152625137 @default.
• W2809619862 cites W2154291410 @default.
• W2809619862 cites W2159973565 @default.
• W2809619862 cites W2160475635 @default.
• W2809619862 cites W2163248301 @default.
• W2809619862 cites W2168526937 @default.
• W2809619862 cites W2181662501 @default.
• W2809619862 cites W2211467290 @default.
• W2809619862 cites W2216690849 @default.
• W2809619862 cites W2327486738 @default.
• W2809619862 cites W2339990273 @default.
• W2809619862 cites W2535078809 @default.
• W2809619862 cites W2556280095 @default.
• W2809619862 cites W2676595667 @default.
• W2809619862 cites W2260502194 @default.
• W2809619862 doi "https://doi.org/10.1111/cmi.12871" @default.
• W2809619862 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6202218" @default.
• W2809619862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29920917" @default.
• W2809619862 hasPublicationYear "2018" @default.
• W2809619862 type Work @default.
• W2809619862 sameAs 2809619862 @default.
• W2809619862 citedByCount "14" @default.
• W2809619862 countsByYear W28096198622019 @default.
• W2809619862 countsByYear W28096198622020 @default.
• W2809619862 countsByYear W28096198622021 @default.
• W2809619862 countsByYear W28096198622022 @default.
• W2809619862 countsByYear W28096198622023 @default.
• W2809619862 crossrefType "journal-article" @default.
• W2809619862 hasAuthorship W2809619862A5008826006 @default.
• W2809619862 hasAuthorship W2809619862A5022402337 @default.
• W2809619862 hasAuthorship W2809619862A5034242696 @default.
• W2809619862 hasAuthorship W2809619862A5057298142 @default.
• W2809619862 hasAuthorship W2809619862A5057736103 @default.
• W2809619862 hasAuthorship W2809619862A5065938813 @default.
• W2809619862 hasAuthorship W2809619862A5077231158 @default.
• W2809619862 hasAuthorship W2809619862A5080597091 @default.
• W2809619862 hasAuthorship W2809619862A5080998067 @default.
• W2809619862 hasBestOaLocation W28096198621 @default.
• W2809619862 hasConcept C100544194 @default.
• W2809619862 hasConcept C126322002 @default.
• W2809619862 hasConcept C134018914 @default.
• W2809619862 hasConcept C16930146 @default.
• W2809619862 hasConcept C181199279 @default.
• W2809619862 hasConcept C2776352991 @default.
• W2809619862 hasConcept C2776651480 @default.
• W2809619862 hasConcept C2777198256 @default.
• W2809619862 hasConcept C2777956040 @default.
• W2809619862 hasConcept C2778078955 @default.

• next