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- W280963730 abstract "Recent reports have shown that L-3H glutamate binds with high affinity to hippocampal membranes (12). Moreover, this binding is increased by CaCl2 (1), although it is still under discussion whether the calcium increase is mediated by chloride ions (11,16). Many authors suggest that Ca2+ can activate neutral protease (2) and that the activity of these proteases could be responsible for learning and memory capability (10). Taurine is a molecule that is able to reduce L-glutamate-induced depolarization in isolated frog spinal cord (7) and to abolish the after-hyperpolarization induced by L-glutamate (8). Moreover, it reduces acquisition of avoidance conditioned reflex (14) and decreases acquisition and, to a lesser extent, retention of a step-down passive avoidance task (13). In the nervous system, taurine interacts with calcium. In fact, 25 mM taurine increases the high affinity Ca2+ binding to rat hippocampal membranes but has no effect on low affinity Ca2+ uptake to rat brain synaptosomes (6).KeywordsNeutral ProteaseScatchard AnalysisCold Distil WaterPreincubation PeriodFrog Spinal CordThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W280963730 date "1987-01-01" @default.
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- W280963730 title "The Effect of Taurine on Excitatory Receptor Binding in Rat Hippocampal Membranes" @default.
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- W280963730 doi "https://doi.org/10.1007/978-1-4899-0405-8_34" @default.
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