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- W2809639128 abstract "Staphylococcus aureus is a multidrug-resistant bacterium responsible for several cases of hospital-acquired infections, which constitute a global public health problem. The introduction of new healthcare strategies and/or the discovery of molecules capable of inhibiting the growth or killing S. aureus would have a huge impact on the treatment of S. aureus-mediated diseases. Herein, a Bowman-Birk protease inhibitor ( LzaBBI), with strong in vitro antibacterial activity against S. aureus, was purified to homogeneity from Luetzelburgia auriculata seeds. LzaBBI in its native form is a 14.3 kDa protein and has a pI of 4.54, and its NH2-terminal sequence has high identity with other Bowman-Birk inhibitors. LzaBBI showed a mixed-type inhibitory activity against both trypsin and chymotrypsin, respectively, and it remained stable after both boiling at 98 °C for 120 min and incubation at various pHs. Scanning electron microscopy revealed that LzaBBI disrupted the S. aureus membrane integrity, leading to bacterial death. This study suggests that LzaBBI is a powerful candidate for developing a new antimicrobial to overcome drug resistance toward reducing hospital-acquired infections caused by S. aureus." @default.
- W2809639128 created "2018-06-29" @default.
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- W2809639128 date "2018-06-21" @default.
- W2809639128 modified "2023-10-15" @default.
- W2809639128 title "A Bowman–Birk Inhibitor from the Seeds of<i>Luetzelburgia auriculata</i>Inhibits<i>Staphylococcus aureus</i>Growth by Promoting Severe Cell Membrane Damage" @default.
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- W2809639128 doi "https://doi.org/10.1021/acs.jnatprod.7b00545" @default.
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