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- W2809783990 abstract "The naphterpins and marinones are naphthoquinone meroterpenoids with an unusual aromatic oxidation pattern that is biosynthesized from 1,3,6,8-tetrahydroxynaphthalene (THN). We propose that cryptic halogenation of THN derivatives by vanadium-dependent chloroperoxidase (VCPO) enzymes is key to this biosynthetic pathway, despite the absence of chlorine in these natural products. This speculation inspired a total synthesis to mimic the naphterpin/marinone biosynthetic pathway. In validation of this biogenetic hypothesis, two VCPOs were discovered that interconvert several of the proposed biosynthetic intermediates." @default.
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- W2809783990 date "2018-07-23" @default.
- W2809783990 modified "2023-10-09" @default.
- W2809783990 title "Total Synthesis Establishes the Biosynthetic Pathway to the Naphterpin and Marinone Natural Products" @default.
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- W2809783990 doi "https://doi.org/10.1002/anie.201804351" @default.
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