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- W2809792156 abstract "Abstract Age‐ and gender‐related variability of main lymphocyte subsets (T, B and NK cell absolute counts and percentages from Ly; T4, T8 and DN cell absolute counts and percentages from lymphocytes and from T cells; T4:T8 and T:B ratios) was studied in a large cohort of paediatric patients (2 days‐17 years) at yearly intervals. A total of 4128 six‐color TBNK tests performed on BD FACSC anto II flow cytometer were assessed; patients with immune deficiencies and tumours were not included. The study revealed significant age‐ and gender‐related changes in all subsets. Absolute counts of T, B, T4 cells dropped from neonates to adolescents, decrease in T8 and NK cells was milder; relative count of T cells increased with age and that of B cells decreased; T4:T8 ratio went down and T:B ratio grew. Total T, T4 cells and T4:T8 ratio were significantly higher in girls, while T8, NK and DN cells were significantly higher in boys; significantly higher relative and absolute B cell counts in boys appeared in adolescence. We compared our results with reference values for healthy children (Tosato et al, Cytometry A . 2015;87:81); there was a good concordance, except for DN cells. Advantages of using patient cohort instead of healthy children as reference, possibilities for adjusting age‐ and gender‐specific reference ranges and potential international data pooling are discussed." @default.
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- W2809792156 date "2018-07-20" @default.
- W2809792156 modified "2023-10-17" @default.
- W2809792156 title "Significant age- and gender-related variability of main lymphocyte subsets in paediatric patients: Latvian data" @default.
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- W2809792156 doi "https://doi.org/10.1111/sji.12696" @default.
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