Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809802023> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2809802023 endingPage "S249" @default.
- W2809802023 startingPage "S249" @default.
- W2809802023 abstract "Evaluate historical treatment practices and patient outcomes in acute myeloid leukemia (AML) at a single institution between patients with FLT3-mutated and FLT3-wildtype AML This retrospective, observational study identified FLT3-tested AML patients treated with 7+3 induction chemotherapy from 2007-2016 at Huntsman Cancer Institute. Complete response (CR), relapse rates, and overall survival (OS) were compared in FLT3-mutated and FLT3-wildtype. One hundred patients (39 FLT3-mutated) were identified with a median age of 53 years. The CR rate to induction chemotherapy was 90% and 77% in FLT3-mutated and FLT3-wildtype, p=0.22. FLT3-mutated patients received fewer consolidation cycles than FLT3-wildtype (median 2 vs 3, p=0.0009) and were more likely to undergo transplant after consolidation (59% vs 25%, p=0.0079). Median time to transplant was 125 vs 186 days in FLT3-mutated and FLT3-wildtype, p=0.0028. After response to induction, 49% and 59% of FLT3-mutated and FLT3-wildtype patients relapsed, p=0.032. Salvage chemotherapy was administered to 38% (n=15) and 56% (n=34) of FLT3-mutated and FLT3-wildtype patients (p=0.092), and significantly fewer FLT3-mutated patients achieved a CR to salvage chemotherapy (40% [n=6] vs 74% [n=24], p=0.045). Median time to salvage chemotherapy was 218 vs 343 days in FLT3-mutated and FLT3-wildtype (p=0.056). A trend for shorter OS was observed in FLT3-mutated (HR 1.56; 95% CI 0.73-3.27; p=0.24). After censoring for transplant, OS was significantly shorter in FLT3-mutated (HR 4.81; 95% CI 1.61-14.39, p=0.006). Similar OS, CR and relapse rates were observed, although FLT3- mutated patients underwent transplant earlier and more frequently than FLT3-wildtype. In those without transplant, FLT3 survival was shorter than wildtype. Upon relapse, FLT3- mutated patients were less likely to respond to salvage treatment. This data resource will be expanded to similar institutions in the future to assess the impact of treatments recently approved for patients with FLT3-mutated AML." @default.
- W2809802023 created "2018-07-10" @default.
- W2809802023 creator A5013411479 @default.
- W2809802023 creator A5023586265 @default.
- W2809802023 creator A5024053204 @default.
- W2809802023 creator A5041166424 @default.
- W2809802023 creator A5044119496 @default.
- W2809802023 creator A5045813475 @default.
- W2809802023 creator A5053195105 @default.
- W2809802023 creator A5056739096 @default.
- W2809802023 creator A5058741297 @default.
- W2809802023 creator A5059369084 @default.
- W2809802023 creator A5079826142 @default.
- W2809802023 creator A5080404720 @default.
- W2809802023 date "2018-05-01" @default.
- W2809802023 modified "2023-09-30" @default.
- W2809802023 title "FLT3 Mutated and Wildtype Acute Myeloid Leukemia Treatment Patterns and Outcomes at a Comprehensive Cancer Center" @default.
- W2809802023 doi "https://doi.org/10.1016/j.jval.2018.04.1687" @default.
- W2809802023 hasPublicationYear "2018" @default.
- W2809802023 type Work @default.
- W2809802023 sameAs 2809802023 @default.
- W2809802023 citedByCount "0" @default.
- W2809802023 crossrefType "journal-article" @default.
- W2809802023 hasAuthorship W2809802023A5013411479 @default.
- W2809802023 hasAuthorship W2809802023A5023586265 @default.
- W2809802023 hasAuthorship W2809802023A5024053204 @default.
- W2809802023 hasAuthorship W2809802023A5041166424 @default.
- W2809802023 hasAuthorship W2809802023A5044119496 @default.
- W2809802023 hasAuthorship W2809802023A5045813475 @default.
- W2809802023 hasAuthorship W2809802023A5053195105 @default.
- W2809802023 hasAuthorship W2809802023A5056739096 @default.
- W2809802023 hasAuthorship W2809802023A5058741297 @default.
- W2809802023 hasAuthorship W2809802023A5059369084 @default.
- W2809802023 hasAuthorship W2809802023A5079826142 @default.
- W2809802023 hasAuthorship W2809802023A5080404720 @default.
- W2809802023 hasBestOaLocation W28098020231 @default.
- W2809802023 hasConcept C104317684 @default.
- W2809802023 hasConcept C126322002 @default.
- W2809802023 hasConcept C143065580 @default.
- W2809802023 hasConcept C143998085 @default.
- W2809802023 hasConcept C207583985 @default.
- W2809802023 hasConcept C2776694085 @default.
- W2809802023 hasConcept C2778336483 @default.
- W2809802023 hasConcept C2778729363 @default.
- W2809802023 hasConcept C2780073493 @default.
- W2809802023 hasConcept C54355233 @default.
- W2809802023 hasConcept C71924100 @default.
- W2809802023 hasConcept C86803240 @default.
- W2809802023 hasConcept C90924648 @default.
- W2809802023 hasConceptScore W2809802023C104317684 @default.
- W2809802023 hasConceptScore W2809802023C126322002 @default.
- W2809802023 hasConceptScore W2809802023C143065580 @default.
- W2809802023 hasConceptScore W2809802023C143998085 @default.
- W2809802023 hasConceptScore W2809802023C207583985 @default.
- W2809802023 hasConceptScore W2809802023C2776694085 @default.
- W2809802023 hasConceptScore W2809802023C2778336483 @default.
- W2809802023 hasConceptScore W2809802023C2778729363 @default.
- W2809802023 hasConceptScore W2809802023C2780073493 @default.
- W2809802023 hasConceptScore W2809802023C54355233 @default.
- W2809802023 hasConceptScore W2809802023C71924100 @default.
- W2809802023 hasConceptScore W2809802023C86803240 @default.
- W2809802023 hasConceptScore W2809802023C90924648 @default.
- W2809802023 hasLocation W28098020231 @default.
- W2809802023 hasOpenAccess W2809802023 @default.
- W2809802023 hasPrimaryLocation W28098020231 @default.
- W2809802023 hasRelatedWork W2091720821 @default.
- W2809802023 hasRelatedWork W2172122575 @default.
- W2809802023 hasRelatedWork W2353335878 @default.
- W2809802023 hasRelatedWork W2377618888 @default.
- W2809802023 hasRelatedWork W2388730008 @default.
- W2809802023 hasRelatedWork W2406230970 @default.
- W2809802023 hasRelatedWork W3031299550 @default.
- W2809802023 hasRelatedWork W3114061532 @default.
- W2809802023 hasRelatedWork W4303832889 @default.
- W2809802023 hasRelatedWork W4362521439 @default.
- W2809802023 hasVolume "21" @default.
- W2809802023 isParatext "false" @default.
- W2809802023 isRetracted "false" @default.
- W2809802023 magId "2809802023" @default.
- W2809802023 workType "article" @default.