FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809815475> ?p ?o ?g. }

• W2809815475 endingPage "1485" @default.
• W2809815475 startingPage "1471" @default.
• W2809815475 abstract "The polyubiquitin gene ubiquitin C ( UBC ) is considered a stress protective gene and is upregulated under various stressful conditions, which is probably a consequence of an increased demand for ubiquitin in order to remove toxic misfolded proteins. We previously identified heat shock elements ( HSE s) within the UBC promoter, which are responsible for heat shock factor ( HSF )1‐driven induction of the UBC gene and are activated by proteotoxic stress. Here, we determined the molecular players driving the UBC gene transcriptional response to arsenite treatment, mainly addressing the role of the nuclear factor‐erythroid 2‐related factor 2 (Nrf2)‐mediated antioxidant pathway. Exposure of HeLa cells to arsenite caused a time‐dependent increase of UBC mRNA , while cell viability and proteasome activity were not affected. Nuclear accumulation of HSF 1 and Nrf2 transcription factors was detected upon both arsenite and MG 132 treatment, while HSF 2 nuclear levels increased in MG 132‐treated cells. Notably, si RNA ‐mediated knockdown of Nrf2 did not reduce UBC transcription under either basal or stressful conditions, but significantly impaired the constitutive and inducible expression of well‐known antioxidant response element‐dependent genes. A chromatin immunoprecipitation assay consistently failed to detect Nrf2 binding to the UBC promoter sequence. By contrast, depletion of HSF 1, but not HSF 2, significantly compromised stress‐induced UBC expression. Critically, HSF 1‐mediated UBC trans ‐activation upon arsenite exposure relies on transcription factor binding to previously mapped distal HSE s, as demonstrated to occur under proteasome inhibition. These data highlight HSF 1 as the pivotal transcription factor that translates different stress signals into UBC gene transcriptional induction." @default.
• W2809815475 created "2018-07-10" @default.
• W2809815475 creator A5023803862 @default.
• W2809815475 creator A5032278474 @default.
• W2809815475 creator A5054798875 @default.
• W2809815475 creator A5070126918 @default.
• W2809815475 date "2018-07-24" @default.
• W2809815475 modified "2023-10-18" @default.
• W2809815475 title "Induction of <i>ubiquitin C</i> ( <i> <scp>UBC</scp> </i> ) gene transcription is mediated by <scp>HSF</scp> 1: role of proteotoxic and oxidative stress" @default.
• W2809815475 cites W1529357822 @default.
• W2809815475 cites W1558003391 @default.
• W2809815475 cites W1572853479 @default.
• W2809815475 cites W1932107019 @default.
• W2809815475 cites W1953874099 @default.
• W2809815475 cites W1970983079 @default.
• W2809815475 cites W1976655661 @default.
• W2809815475 cites W1991631628 @default.
• W2809815475 cites W1996851821 @default.
• W2809815475 cites W2008344420 @default.
• W2809815475 cites W2012296420 @default.
• W2809815475 cites W2016445982 @default.
• W2809815475 cites W2023524211 @default.
• W2809815475 cites W2026731344 @default.
• W2809815475 cites W2031153505 @default.
• W2809815475 cites W2032459623 @default.
• W2809815475 cites W2032852681 @default.
• W2809815475 cites W2033642325 @default.
• W2809815475 cites W2045787491 @default.
• W2809815475 cites W2049488033 @default.
• W2809815475 cites W2056671529 @default.
• W2809815475 cites W2057491765 @default.
• W2809815475 cites W2063312601 @default.
• W2809815475 cites W2063690778 @default.
• W2809815475 cites W2071960601 @default.
• W2809815475 cites W2078324140 @default.
• W2809815475 cites W2080435498 @default.
• W2809815475 cites W2086331217 @default.
• W2809815475 cites W2089099219 @default.
• W2809815475 cites W2093304538 @default.
• W2809815475 cites W2103740237 @default.
• W2809815475 cites W2103805605 @default.
• W2809815475 cites W2107277218 @default.
• W2809815475 cites W2123322767 @default.
• W2809815475 cites W2128296472 @default.
• W2809815475 cites W2138636270 @default.
• W2809815475 cites W2140452134 @default.
• W2809815475 cites W2147917253 @default.
• W2809815475 cites W2148143293 @default.
• W2809815475 cites W2150123812 @default.
• W2809815475 cites W2151614363 @default.
• W2809815475 cites W2153550523 @default.
• W2809815475 cites W2165178917 @default.
• W2809815475 cites W2166987747 @default.
• W2809815475 cites W2175833749 @default.
• W2809815475 cites W2192080449 @default.
• W2809815475 cites W2283862988 @default.
• W2809815475 cites W2326884456 @default.
• W2809815475 cites W2327955945 @default.
• W2809815475 cites W2571523888 @default.
• W2809815475 cites W2591324209 @default.
• W2809815475 cites W2750054522 @default.
• W2809815475 cites W2756666450 @default.
• W2809815475 cites W829805959 @default.
• W2809815475 cites W918777403 @default.
• W2809815475 cites W952491933 @default.
• W2809815475 doi "https://doi.org/10.1002/2211-5463.12484" @default.
• W2809815475 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6120222" @default.
• W2809815475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30186748" @default.
• W2809815475 hasPublicationYear "2018" @default.
• W2809815475 type Work @default.
• W2809815475 sameAs 2809815475 @default.
• W2809815475 citedByCount "22" @default.
• W2809815475 countsByYear W28098154752018 @default.
• W2809815475 countsByYear W28098154752019 @default.
• W2809815475 countsByYear W28098154752020 @default.
• W2809815475 countsByYear W28098154752021 @default.
• W2809815475 countsByYear W28098154752022 @default.
• W2809815475 countsByYear W28098154752023 @default.
• W2809815475 crossrefType "journal-article" @default.
• W2809815475 hasAuthorship W2809815475A5023803862 @default.
• W2809815475 hasAuthorship W2809815475A5032278474 @default.
• W2809815475 hasAuthorship W2809815475A5054798875 @default.
• W2809815475 hasAuthorship W2809815475A5070126918 @default.
• W2809815475 hasBestOaLocation W28098154751 @default.
• W2809815475 hasConcept C101762097 @default.
• W2809815475 hasConcept C104317684 @default.
• W2809815475 hasConcept C134320426 @default.
• W2809815475 hasConcept C138885662 @default.
• W2809815475 hasConcept C150194340 @default.
• W2809815475 hasConcept C153911025 @default.
• W2809815475 hasConcept C173396325 @default.
• W2809815475 hasConcept C179926584 @default.
• W2809815475 hasConcept C205260736 @default.
• W2809815475 hasConcept C27740335 @default.
• W2809815475 hasConcept C2776667301 @default.
• W2809815475 hasConcept C41895202 @default.
• W2809815475 hasConcept C52981337 @default.
• W2809815475 hasConcept C55493867 @default.

• next