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- W2809840981 abstract "Increasing evidence reveals a close and reciprocal link between acute-on-chronic liver failure (ACLF) and immunodysfunction.A literature search in PubMed and abstract databases of relevant congresses was performed.Important characteristics of liver cirrhosis like tissue hypoxia, cell death, or bacterial translocation maintain a state of chronic inflammation. Precipitating events of ACLF such as infections or alcoholic hepatitis are capable of strongly augmenting cirrhosis-associated systemic inflammation to grades sufficient to induce ACLF-defining organ failures. Chronic systemic inflammation, however, is causally linked to profound immunosuppression. As a consequence, patients with liver cirrhosis and in particular with ACLF are at high risk for severe infections. Promising strategies to ameliorate immunodysfunction, like albumin substitution, administration of recombinant interleukin-22 or granulocyte colony-stimulating factor, antibiotic prophylaxis, or anticoagulation, are under development and offer the chance to specifically prevent and treat ACLF.A better understanding of the immunopathology of ACLF will likely translate into the implementation of specific therapeutic modalities to prevent and overcome ACLF." @default.
- W2809840981 created "2018-07-10" @default.
- W2809840981 creator A5001302118 @default.
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- W2809840981 date "2018-01-01" @default.
- W2809840981 modified "2023-10-16" @default.
- W2809840981 title "Immunodysfunction in Acute-on-Chronic Liver Failure" @default.
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- W2809840981 doi "https://doi.org/10.1159/000488690" @default.
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