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- W2809848981 abstract "Objective: MUC16/CA-125 is a transmembrane mucin that drives oncogenic behavior. Its extracellular membrane domain interacts with the lectin, galectin-3 (Gal-3), and through this interaction initiates a signal cascade leading to cancer cell invasion and growth. We aim to interrupt this interaction by a high-affinity anti-Gal-3 antibody directed at the carbohydrate recognition domain (CRD) of the Gal-3 carboxyl-terminus." @default.
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- W2809848981 date "2018-06-01" @default.
- W2809848981 modified "2023-09-25" @default.
- W2809848981 title "Development of a high-affinity anti-galectin-3 antibody targeting interactions between MUC16/CA-125 and galectin-3 to inhibit oncogenic properties in serous ovarian cancer" @default.
- W2809848981 doi "https://doi.org/10.1016/j.ygyno.2018.04.036" @default.
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