FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809861575> ?p ?o ?g. }

• W2809861575 abstract "The aim of the present study was to determine the expression of adenosine triphosphate binding cassette subfamily B member 1 (ABCB1) gene and its protein P‑glycoprotein (PGP) in bone marrow mononuclear cells from chronic myeloid leukemia (CML) patients with imatinib mesylate (IM) resistance, or IM‑resistant CML K562 cells. In addition, the molecular mechanism of action of microRNA (miR)‑214 on ABCB1 in IM resistance was investigated. A total of 26 CML patients with IM resistance were included in the present study. In addition, 31 CML patients who did not have IM resistance were included as the control group. Bone marrow was collected from all subjects. The K562R cell line, which is a K562 cell line with IM resistance, was used for cellular studies. Reverse transcription‑quantitative polymerase chain reaction was used to determine the expression of ABCB1 mRNA and miR‑214 in cells. Western blotting was employed to determine the expression of PGP. Dual luciferase reporter assay was carried out to identify interactions between ABCB1 mRNA and miR‑214. MTT assay was used to determine the survival rate of cells. ABCB1 mRNA and PGP expression was upregulated in bone marrow mononuclear cells from CML patients with IM resistance. K562R cells had higher ABCB1 and PGP expression than K562 cells, potentially due to their different sensitivity to IM. Expression miR‑214 was decreased in bone marrow mononuclear cells from patients with IM resistance and K562R cells. Notably, miR‑214 was able to bind with the 3'‑untranslated region, seed region of ABCB1 mRNA to regulate its expression. In addition, elevated expression of miR‑214 restored IM sensitivity to K562R cells potentially by affecting ABCB1 expression. The present study demonstrated that upregulated expression of ABCB1 mRNA and PGP in bone marrow mononuclear cells from CML patients with IM resistance may be associated with the downregulation of miR‑214. In addition, miR‑214 may participate in the IM resistance of CML patients by regulating ABCB1 expression." @default.
• W2809861575 created "2018-07-10" @default.
• W2809861575 creator A5000018634 @default.
• W2809861575 creator A5038851564 @default.
• W2809861575 creator A5044622075 @default.
• W2809861575 creator A5058336972 @default.
• W2809861575 creator A5073318780 @default.
• W2809861575 creator A5082156574 @default.
• W2809861575 date "2018-07-04" @default.
• W2809861575 modified "2023-10-18" @default.
• W2809861575 title "Decreased expression of microRNA‑214 contributes to imatinib mesylate resistance of chronic myeloid leukemia patients by upregulating ABCB1 gene expression" @default.
• W2809861575 cites W1580490353 @default.
• W2809861575 cites W1964470226 @default.
• W2809861575 cites W1967700449 @default.
• W2809861575 cites W1981033376 @default.
• W2809861575 cites W1989270901 @default.
• W2809861575 cites W1999277101 @default.
• W2809861575 cites W2016318120 @default.
• W2809861575 cites W2018195863 @default.
• W2809861575 cites W2031934286 @default.
• W2809861575 cites W2032287776 @default.
• W2809861575 cites W2033931090 @default.
• W2809861575 cites W2070440937 @default.
• W2809861575 cites W2072283445 @default.
• W2809861575 cites W2075193502 @default.
• W2809861575 cites W2076272022 @default.
• W2809861575 cites W2081213990 @default.
• W2809861575 cites W2107277218 @default.
• W2809861575 cites W2109774960 @default.
• W2809861575 cites W2110753217 @default.
• W2809861575 cites W2117356576 @default.
• W2809861575 cites W2118388287 @default.
• W2809861575 cites W2122443624 @default.
• W2809861575 cites W2125781656 @default.
• W2809861575 cites W2131171876 @default.
• W2809861575 cites W2140116051 @default.
• W2809861575 cites W2140180971 @default.
• W2809861575 cites W2151486690 @default.
• W2809861575 cites W2152481210 @default.
• W2809861575 cites W2160067668 @default.
• W2809861575 cites W2162592548 @default.
• W2809861575 cites W2166641737 @default.
• W2809861575 cites W2184989429 @default.
• W2809861575 cites W2192080449 @default.
• W2809861575 cites W2346845651 @default.
• W2809861575 cites W2403325203 @default.
• W2809861575 cites W2417879879 @default.
• W2809861575 cites W2431414621 @default.
• W2809861575 cites W2460814647 @default.
• W2809861575 cites W2476246088 @default.
• W2809861575 cites W2481451033 @default.
• W2809861575 cites W2518539609 @default.
• W2809861575 cites W2613388304 @default.
• W2809861575 cites W2625464213 @default.
• W2809861575 cites W2992837203 @default.
• W2809861575 cites W4232733723 @default.
• W2809861575 cites W749043895 @default.
• W2809861575 doi "https://doi.org/10.3892/etm.2018.6404" @default.
• W2809861575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6122133" @default.
• W2809861575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30186389" @default.
• W2809861575 hasPublicationYear "2018" @default.
• W2809861575 type Work @default.
• W2809861575 sameAs 2809861575 @default.
• W2809861575 citedByCount "7" @default.
• W2809861575 countsByYear W28098615752020 @default.
• W2809861575 countsByYear W28098615752022 @default.
• W2809861575 countsByYear W28098615752023 @default.
• W2809861575 crossrefType "journal-article" @default.
• W2809861575 hasAuthorship W2809861575A5000018634 @default.
• W2809861575 hasAuthorship W2809861575A5038851564 @default.
• W2809861575 hasAuthorship W2809861575A5044622075 @default.
• W2809861575 hasAuthorship W2809861575A5058336972 @default.
• W2809861575 hasAuthorship W2809861575A5073318780 @default.
• W2809861575 hasAuthorship W2809861575A5082156574 @default.
• W2809861575 hasBestOaLocation W28098615751 @default.
• W2809861575 hasConcept C104317684 @default.
• W2809861575 hasConcept C137061746 @default.
• W2809861575 hasConcept C145059251 @default.
• W2809861575 hasConcept C1491633281 @default.
• W2809861575 hasConcept C153911025 @default.
• W2809861575 hasConcept C171122931 @default.
• W2809861575 hasConcept C202751555 @default.
• W2809861575 hasConcept C203014093 @default.
• W2809861575 hasConcept C2777583451 @default.
• W2809861575 hasConcept C2778461978 @default.
• W2809861575 hasConcept C2778729363 @default.
• W2809861575 hasConcept C2780007613 @default.
• W2809861575 hasConcept C2781018059 @default.
• W2809861575 hasConcept C29537977 @default.
• W2809861575 hasConcept C3019892230 @default.
• W2809861575 hasConcept C502942594 @default.
• W2809861575 hasConcept C55493867 @default.
• W2809861575 hasConcept C86803240 @default.
• W2809861575 hasConceptScore W2809861575C104317684 @default.
• W2809861575 hasConceptScore W2809861575C137061746 @default.
• W2809861575 hasConceptScore W2809861575C145059251 @default.
• W2809861575 hasConceptScore W2809861575C1491633281 @default.
• W2809861575 hasConceptScore W2809861575C153911025 @default.
• W2809861575 hasConceptScore W2809861575C171122931 @default.
• W2809861575 hasConceptScore W2809861575C202751555 @default.

• next