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• W2809883003 abstract "Abstract Background Oropharyngeal dysphagia ( OD ) is a prevalent disease with poor prognosis among older people and has no pharmacological treatment. Polymodal sensory receptors like the TRP or ASIC family receptors are potential targets to treat OD . TRPM 8 agonists and acidic solutions can improve the swallow response in patients with OD , but little is known about the expression of TRPM 8, ASIC 1, and ASIC 3 in the human oropharynx. The aim of this study was to assess the expression and localization of TRPM 8, ASIC 1, and ASIC 3 in human samples of the oropharynx to lay the basis for new pharmacological treatments for OD . Methods Pathology‐free samples from oropharyngeal regions innervated by cranial nerves V, IX , and X were obtained during major ENT surgery and processed to obtain mRNA (20 patients) or to be used in immunohistochemical assays (12 patients). TRPM 8, ASIC 1, and ASIC 3 expression and localization were studied with RT ‐ qPCR and fluorescent immunohistochemistry. Key Results ASIC 3 was expressed in the 3 regions studied with similar levels and was localized on sensory fibers innervating the mucosa below the basal lamina of all studied regions. TRPM 8 was also co‐localized on the sensory fibers innervating the mucosa below the basal lamina of all studied regions. In contrast, ASIC 1 was only found in the nerves innervating the tongue muscular fibers. Conclusions & Inferences TRPM 8 and ASIC 3 are found on submucosal sensory nerves in the human oropharynx. Our study lays the basis to use oropharyngeal TRPM 8 and ASIC 3 receptors as therapeutic targets to develop new active pharmacological treatments for OD patients." @default.
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• W2809883003 date "2018-07-04" @default.
• W2809883003 modified "2023-10-06" @default.
• W2809883003 title "TRPM8, ASIC1, and ASIC3 localization and expression in the human oropharynx" @default.
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• W2809883003 doi "https://doi.org/10.1111/nmo.13398" @default.
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