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- W2809892982 abstract "PurposeThe purpose of the current review is to highlight, on one hand, the fact that the migratory pattern of glioma cells is the major obstacle to combat them with chemotherapy, and on the other one, the new treatment strategies to overcome this obstacle.MethodsThis review surveys several membrane and extracellular molecules involved in glioma cell migration, invasiveness and resistance to apoptosis.ResultsThis review focuses on signaling pathways implicated in the positive regulation of glioblastoma cell migration, including glutamate and ion channel networks, microtubes and membrane-derived extracellular vesicles (EV) containing microRNAs. Glioma cells release glutamate to the extracellular matrix, inducing neuronal cell death, which may facilitate glioma growth and invasion. Glioma cell migration and invasion are further facilitated through ion channels and transporters that modify cellular volume. Microtubes and EV promote connections and communication among glioma cells and with the microenvironment and are associated with progression and resistance to therapy. Potential therapies linked to these pathways for glioblastoma are being developed.ConclusionOur view is evolving from an intracellular view of the complex intracellular signaling pathways to one of orchestral machinery, including connections between heterogeneous tumoral and nontumoral cells and with the microenvironment through channels, microtubes, and extracellular miRNA, generating different signals at different times. All of these elements give rise to a new perspective for the treatment of glioblastoma." @default.
- W2809892982 created "2018-07-10" @default.
- W2809892982 creator A5017177249 @default.
- W2809892982 creator A5033613763 @default.
- W2809892982 creator A5050210411 @default.
- W2809892982 creator A5062409032 @default.
- W2809892982 date "2018-07-01" @default.
- W2809892982 modified "2023-10-01" @default.
- W2809892982 title "Glioblastoma quo vadis : Will migration and invasiveness reemerge as therapeutic targets?" @default.
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