Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809901480> ?p ?o ?g. }
- W2809901480 abstract "Abstract Determining whether recurrent but rare cancer mutations are bona fide driver mutations remains a bottleneck in cancer research. Here we present the most comprehensive analysis of murine leukemia virus-driven lymphomagenesis produced to date, sequencing 700,000 mutations from >500 malignancies collected at time points throughout tumor development. This scale of data allows novel statistical approaches for identifying selected mutations and yields a high-resolution, genome-wide map of the selective forces surrounding cancer gene loci. We also demonstrate negative selection of mutations that may be deleterious to tumor development indicating novel avenues for therapy. Screening of two BCL2 transgenic models confirmed known drivers of human non-Hodgkin lymphoma, and implicates novel candidates including modifiers of immunosurveillance and MHC loci. Correlating mutations with genotypic and phenotypic features independently of local variance in mutation density also provides support for weakly evidenced cancer genes. An online resource http://mulvdb.org allows customized queries of the entire dataset." @default.
- W2809901480 created "2018-07-10" @default.
- W2809901480 creator A5001734551 @default.
- W2809901480 creator A5006712830 @default.
- W2809901480 creator A5009159444 @default.
- W2809901480 creator A5015897147 @default.
- W2809901480 creator A5021785258 @default.
- W2809901480 creator A5023259750 @default.
- W2809901480 creator A5025481307 @default.
- W2809901480 creator A5030607460 @default.
- W2809901480 creator A5033114100 @default.
- W2809901480 creator A5036728573 @default.
- W2809901480 creator A5039276249 @default.
- W2809901480 creator A5040895879 @default.
- W2809901480 creator A5068558089 @default.
- W2809901480 creator A5069026748 @default.
- W2809901480 creator A5071898542 @default.
- W2809901480 creator A5073987546 @default.
- W2809901480 creator A5074016040 @default.
- W2809901480 creator A5076209108 @default.
- W2809901480 creator A5081319975 @default.
- W2809901480 date "2018-07-09" @default.
- W2809901480 modified "2023-10-16" @default.
- W2809901480 title "Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates" @default.
- W2809901480 cites W137116573 @default.
- W2809901480 cites W1504853565 @default.
- W2809901480 cites W1847375317 @default.
- W2809901480 cites W1965322366 @default.
- W2809901480 cites W1966646007 @default.
- W2809901480 cites W1977295792 @default.
- W2809901480 cites W1977572305 @default.
- W2809901480 cites W1983105816 @default.
- W2809901480 cites W1983672911 @default.
- W2809901480 cites W1984065010 @default.
- W2809901480 cites W1988323955 @default.
- W2809901480 cites W1998352493 @default.
- W2809901480 cites W2001663034 @default.
- W2809901480 cites W2009720434 @default.
- W2809901480 cites W2011228017 @default.
- W2809901480 cites W2015410907 @default.
- W2809901480 cites W2016770717 @default.
- W2809901480 cites W2029503535 @default.
- W2809901480 cites W2033226263 @default.
- W2809901480 cites W2034118113 @default.
- W2809901480 cites W2035322315 @default.
- W2809901480 cites W2041126567 @default.
- W2809901480 cites W2050316407 @default.
- W2809901480 cites W2060579599 @default.
- W2809901480 cites W2064571866 @default.
- W2809901480 cites W2067637687 @default.
- W2809901480 cites W2072719177 @default.
- W2809901480 cites W2080660780 @default.
- W2809901480 cites W2088182134 @default.
- W2809901480 cites W2094122486 @default.
- W2809901480 cites W2102140136 @default.
- W2809901480 cites W2106389431 @default.
- W2809901480 cites W2107092366 @default.
- W2809901480 cites W2107780904 @default.
- W2809901480 cites W2119967034 @default.
- W2809901480 cites W2125640515 @default.
- W2809901480 cites W2128016314 @default.
- W2809901480 cites W2136640137 @default.
- W2809901480 cites W2138883729 @default.
- W2809901480 cites W2143197030 @default.
- W2809901480 cites W2147640800 @default.
- W2809901480 cites W2149441684 @default.
- W2809901480 cites W2153202563 @default.
- W2809901480 cites W2154530408 @default.
- W2809901480 cites W2160183527 @default.
- W2809901480 cites W2197131615 @default.
- W2809901480 cites W2274436427 @default.
- W2809901480 cites W2301449312 @default.
- W2809901480 cites W2344657883 @default.
- W2809901480 cites W245290219 @default.
- W2809901480 cites W2537349510 @default.
- W2809901480 cites W2978725006 @default.
- W2809901480 cites W4244151789 @default.
- W2809901480 cites W4376999543 @default.
- W2809901480 doi "https://doi.org/10.1038/s41467-018-05069-9" @default.
- W2809901480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6037733" @default.
- W2809901480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29985390" @default.
- W2809901480 hasPublicationYear "2018" @default.
- W2809901480 type Work @default.
- W2809901480 sameAs 2809901480 @default.
- W2809901480 citedByCount "2" @default.
- W2809901480 countsByYear W28099014802020 @default.
- W2809901480 countsByYear W28099014802021 @default.
- W2809901480 crossrefType "journal-article" @default.
- W2809901480 hasAuthorship W2809901480A5001734551 @default.
- W2809901480 hasAuthorship W2809901480A5006712830 @default.
- W2809901480 hasAuthorship W2809901480A5009159444 @default.
- W2809901480 hasAuthorship W2809901480A5015897147 @default.
- W2809901480 hasAuthorship W2809901480A5021785258 @default.
- W2809901480 hasAuthorship W2809901480A5023259750 @default.
- W2809901480 hasAuthorship W2809901480A5025481307 @default.
- W2809901480 hasAuthorship W2809901480A5030607460 @default.
- W2809901480 hasAuthorship W2809901480A5033114100 @default.
- W2809901480 hasAuthorship W2809901480A5036728573 @default.
- W2809901480 hasAuthorship W2809901480A5039276249 @default.
- W2809901480 hasAuthorship W2809901480A5040895879 @default.