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- W2809907780 abstract "Monascin and ankaflavin, the major fractions of the fungal-derived monascus yellow pigments, were incorporated with the herbal drug, resveratrol (RSV) within the core of folate-conjugated casein micelles (FA-CAS MCs, F1) for active targeting. PEGylated RSV-phospholipid complex bilayer enveloping casein-loaded micelles (PEGPC-CAS MCs) were also developed as passive-targeted nanosystem.FA- and PEGPC-CAS MCs demonstrated a proper size with monomodal distribution, sustained drug release profiles and good hemocompatibility. The coloaded MCs showed superior cytotoxicity to MCF-7 breast cancer cells compared with free drugs. Both nanosystems exerted excellent in vivo antitumor efficacy in breast cancer bearing mice with PEGylated MCs showing comparable tumor regression to folate-conjugated MCs.Evergreen nanoplatforms coloaded with monascus yellow pigments and RSV were effective for breast cancer treatment." @default.
- W2809907780 created "2018-07-10" @default.
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- W2809907780 date "2018-06-01" @default.
- W2809907780 modified "2023-10-10" @default.
- W2809907780 title "Folate conjugated vs PEGylated phytosomal casein nanocarriers for codelivery of fungal- and herbal-derived anticancer drugs" @default.
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- W2809907780 doi "https://doi.org/10.2217/nnm-2018-0006" @default.
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