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- W2809916706 endingPage "517.e3" @default.
- W2809916706 startingPage "508" @default.
- W2809916706 abstract "Abstract Sepsis frequently is accompanied by coagulation abnormalities, increasing the risk of bleeding and/or thrombotic episodes. Sepsis is a complex disorder and becomes further complicated when the coagulation system is altered. This chapter reviews the normal coagulation system and how sepsis can change it. The pathogenesis of sepsis-associated coagulopathy (SAC) is discussed, emphasizing the prothrombotic state of sepsis, the role of cytokines and endothelial injury, and the interaction between coagulation and inflammation. The prothrombotic state of sepsis is characterized by decreased natural anticoagulants (thrombomodulin downregulation), increased expression of tissue factor (TF) on endothelial cells and monocytes, decreased function of the anticoagulant pathways (antithrombin [AT], protein C, and tissue factor pathway inhibitor [TFPI]), increased levels of ultra-large von Willebrand multimers, and decreased levels of ADAMTS-13. The major factors involved in the coagulation-inflammation interaction are described, including TF, protease-activated receptors (PARs), neutrophil extracellular trap (NET), and histones. The most important SAC-targeted drugs also are characterized, focusing on drugs in development, such as human recombinant thrombomodulin. Finally, some clinical practice recommendations are discussed briefly in accordance with relevant guidelines." @default.
- W2809916706 created "2018-07-10" @default.
- W2809916706 creator A5018874951 @default.
- W2809916706 creator A5090576091 @default.
- W2809916706 date "2019-01-01" @default.
- W2809916706 modified "2023-09-27" @default.
- W2809916706 title "Coagulation Abnormalities in Sepsis" @default.
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