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• W2809917098 abstract "Beneficial molecular and neuroplastic changes have been demonstrated in response to environmental enrichment (EE) in laboratory animals across the lifespan. Here, we investigated whether these effects extend to C-type Natriuretic Peptide (CNP), a widely expressed neuropeptide with putative involvement in neuroprotection, neuroplasticity, anxiety, and learning and memory. We determined the CNP response in 36 young (8-9 months) and 36 aged (22-23 months) male PVGc hooded rats that were rehoused with new cage mates in either standard laboratory cages or EE for periods of 14 or 28 days. Tissues were rapidly excised from four brain regions associated with memory formation (dorsal hippocampus, retrosplenial cortex, medial prefrontal cortex, and mammillary bodies) plus the occipital cortex and hypothalamus, and immediately frozen. Radioimmunoassay was used to measure bioactive CNP and the amino-terminal fragment of proCNP, NTproCNP. Because CNP but not NTproCNP is rapidly degraded at source, NTproCNP reflects CNP production whereas the ratio NTproCNP:CNP is a biomarker of CNP's local degradation rate. EE increased CNP at 14 days in all brain regions in young, but not old rats; this effect in young rats was lost at 28 days in all regions of interest. NTproCNP:CNP ratio, but not NTproCNP, was reduced in all regions by EE at 14 days in young rats, but not in old rats, which suggests a period of reduced degradation or receptor mediated clearance, rather than increased production of CNP in these young EE rats. Aged rats tended to show reduced NTproCNP:CNP ratios but this did not occur in dorsal hippocampus or mammillary bodies. This is the first study demonstrating modulation of CNP protein concentrations, and the effect of age, in response to environmental stimulation. Furthermore, it is the first to show that changes in degradation rate in vivo may be an important component in determining CNP bioactivity in neural tissues." @default.
• W2809917098 created "2018-07-10" @default.
• W2809917098 creator A5011757089 @default.
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• W2809917098 date "2018-07-19" @default.
• W2809917098 modified "2023-09-27" @default.
• W2809917098 title "Environmental Enrichment Elicits a Transient Rise of Bioactive C-Type Natriuretic Peptide in Young but Not Aged Rats" @default.
• W2809917098 cites W1836315310 @default.
• W2809917098 cites W1841583369 @default.
• W2809917098 cites W188973668 @default.
• W2809917098 cites W1965599652 @default.
• W2809917098 cites W1965683618 @default.
• W2809917098 cites W1967137091 @default.
• W2809917098 cites W1967794260 @default.
• W2809917098 cites W1969077909 @default.
• W2809917098 cites W1971584932 @default.
• W2809917098 cites W1972876743 @default.
• W2809917098 cites W1975336405 @default.
• W2809917098 cites W1975693633 @default.
• W2809917098 cites W1976038658 @default.
• W2809917098 cites W1980783383 @default.
• W2809917098 cites W1981107891 @default.
• W2809917098 cites W1986094330 @default.
• W2809917098 cites W1988240310 @default.
• W2809917098 cites W1996566267 @default.
• W2809917098 cites W1996761750 @default.
• W2809917098 cites W1999107543 @default.
• W2809917098 cites W2001497765 @default.
• W2809917098 cites W2003041124 @default.
• W2809917098 cites W2003410761 @default.
• W2809917098 cites W2006129024 @default.
• W2809917098 cites W2006802243 @default.
• W2809917098 cites W2015853348 @default.
• W2809917098 cites W2017956681 @default.
• W2809917098 cites W2021197734 @default.
• W2809917098 cites W2025214867 @default.
• W2809917098 cites W2027953236 @default.
• W2809917098 cites W2029532449 @default.
• W2809917098 cites W2029860021 @default.
• W2809917098 cites W2030011352 @default.
• W2809917098 cites W2031732830 @default.
• W2809917098 cites W2037187602 @default.
• W2809917098 cites W2037761331 @default.
• W2809917098 cites W2040852295 @default.
• W2809917098 cites W2042401584 @default.
• W2809917098 cites W2046888916 @default.
• W2809917098 cites W2054282296 @default.
• W2809917098 cites W2064161559 @default.
• W2809917098 cites W2064325857 @default.
• W2809917098 cites W2067576490 @default.
• W2809917098 cites W2070676014 @default.
• W2809917098 cites W2072837447 @default.
• W2809917098 cites W2073364218 @default.
• W2809917098 cites W2074764259 @default.
• W2809917098 cites W2076079908 @default.
• W2809917098 cites W2080925376 @default.
• W2809917098 cites W2081164888 @default.
• W2809917098 cites W2082400577 @default.
• W2809917098 cites W2087394027 @default.
• W2809917098 cites W2092996761 @default.
• W2809917098 cites W2093508465 @default.
• W2809917098 cites W2096192426 @default.
• W2809917098 cites W2102248167 @default.
• W2809917098 cites W2105157791 @default.
• W2809917098 cites W2110440702 @default.
• W2809917098 cites W2113676818 @default.
• W2809917098 cites W2117983251 @default.
• W2809917098 cites W2118492208 @default.
• W2809917098 cites W2119175433 @default.
• W2809917098 cites W2126468711 @default.
• W2809917098 cites W2128725121 @default.
• W2809917098 cites W2130004211 @default.
• W2809917098 cites W2131035734 @default.
• W2809917098 cites W2134776708 @default.
• W2809917098 cites W2135796042 @default.
• W2809917098 cites W2151785608 @default.
• W2809917098 cites W2174392497 @default.
• W2809917098 cites W2256426273 @default.
• W2809917098 cites W2319350696 @default.
• W2809917098 cites W233267608 @default.
• W2809917098 cites W2396720565 @default.
• W2809917098 cites W2502906121 @default.
• W2809917098 cites W2675623684 @default.
• W2809917098 cites W2729013260 @default.
• W2809917098 cites W2774401265 @default.
• W2809917098 cites W2947327091 @default.
• W2809917098 doi "https://doi.org/10.3389/fnbeh.2018.00142" @default.
• W2809917098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6060231" @default.
• W2809917098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30072880" @default.
• W2809917098 hasPublicationYear "2018" @default.
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