FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809918268> ?p ?o ?g. }

• W2809918268 endingPage "505" @default.
• W2809918268 startingPage "498" @default.
• W2809918268 abstract "Autoimmune haemolytic anaemia (AIHA) and autoimmune thrombocytopenia are common complications of childhood-onset lupus, which may be life-threatening. A greater understanding of the pathogenesis of these haematologic manifestations will enhance our understanding of the biology of systemic lupus erythematosus (SLE) and inform the identification of novel treatments.The mechanisms underlying AIHA and autoimmune thrombocytopenia are incompletely understood and likely multifactorial. Although the development of auto-antibodies is central to the disease process, recent studies have demonstrated the importance of cytokines in the underlying pathologic process. In-vitro and in-vivo evidence points to a role for IL17 in the pathogenesis of AIHA, which involves loss of tolerance to red cell auto-antigens and the development of autoantibodies. Sirolimus, an mTor inhibitor, has benefited patients with primary autoimmune cytopenias, possibly by stimulating T regulatory cells, and may also have efficacy for SLE-associated cytopenias. Similarly, low-dose recombinant human IL-2 therapy has shown promising results for improving platelet counts in patients with autoimmune thrombocytopenia, possibly by restoring the balance between T regulatory, T helper and Th17 cells.The emergence of new agents directed at restoring immune dysregulation hold promise for the treatment of AIHA and autoimmune thrombocytopenia and should provide better tolerated alternatives to high-dose corticosteroids." @default.
• W2809918268 created "2018-07-10" @default.
• W2809918268 creator A5012083798 @default.
• W2809918268 creator A5019957529 @default.
• W2809918268 date "2018-09-01" @default.
• W2809918268 modified "2023-10-06" @default.
• W2809918268 title "Autoimmune haemolytic anaemia and autoimmune thrombocytopenia in childhood-onset systemic lupus erythematosus: updates on pathogenesis and treatment" @default.
• W2809918268 cites W1139999821 @default.
• W2809918268 cites W1874142609 @default.
• W2809918268 cites W1967726878 @default.
• W2809918268 cites W1978259263 @default.
• W2809918268 cites W1978620649 @default.
• W2809918268 cites W1996924061 @default.
• W2809918268 cites W2003089769 @default.
• W2809918268 cites W2013352098 @default.
• W2809918268 cites W2029539106 @default.
• W2809918268 cites W2038511894 @default.
• W2809918268 cites W2048372452 @default.
• W2809918268 cites W2049006925 @default.
• W2809918268 cites W2055712900 @default.
• W2809918268 cites W2059817169 @default.
• W2809918268 cites W2070527591 @default.
• W2809918268 cites W2086955643 @default.
• W2809918268 cites W2090908423 @default.
• W2809918268 cites W2102520886 @default.
• W2809918268 cites W2110142817 @default.
• W2809918268 cites W2141908051 @default.
• W2809918268 cites W2159860161 @default.
• W2809918268 cites W2165650107 @default.
• W2809918268 cites W2259812842 @default.
• W2809918268 cites W2284354173 @default.
• W2809918268 cites W2298964496 @default.
• W2809918268 cites W2303297332 @default.
• W2809918268 cites W2342342288 @default.
• W2809918268 cites W2417984802 @default.
• W2809918268 cites W2477823035 @default.
• W2809918268 cites W2550938796 @default.
• W2809918268 cites W2552350396 @default.
• W2809918268 cites W2566550079 @default.
• W2809918268 cites W2594159215 @default.
• W2809918268 cites W2605168845 @default.
• W2809918268 cites W2620409251 @default.
• W2809918268 cites W2621299446 @default.
• W2809918268 cites W2625419804 @default.
• W2809918268 cites W2749427025 @default.
• W2809918268 cites W2771856822 @default.
• W2809918268 doi "https://doi.org/10.1097/bor.0000000000000523" @default.
• W2809918268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29979258" @default.
• W2809918268 hasPublicationYear "2018" @default.
• W2809918268 type Work @default.
• W2809918268 sameAs 2809918268 @default.
• W2809918268 citedByCount "14" @default.
• W2809918268 countsByYear W28099182682019 @default.
• W2809918268 countsByYear W28099182682020 @default.
• W2809918268 countsByYear W28099182682021 @default.
• W2809918268 countsByYear W28099182682022 @default.
• W2809918268 countsByYear W28099182682023 @default.
• W2809918268 crossrefType "journal-article" @default.
• W2809918268 hasAuthorship W2809918268A5012083798 @default.
• W2809918268 hasAuthorship W2809918268A5019957529 @default.
• W2809918268 hasConcept C126322002 @default.
• W2809918268 hasConcept C159654299 @default.
• W2809918268 hasConcept C162834538 @default.
• W2809918268 hasConcept C163764329 @default.
• W2809918268 hasConcept C172680121 @default.
• W2809918268 hasConcept C203014093 @default.
• W2809918268 hasConcept C2775915377 @default.
• W2809918268 hasConcept C2776912625 @default.
• W2809918268 hasConcept C2777385706 @default.
• W2809918268 hasConcept C2779075594 @default.
• W2809918268 hasConcept C2779134260 @default.
• W2809918268 hasConcept C2779234561 @default.
• W2809918268 hasConcept C2780130043 @default.
• W2809918268 hasConcept C2780194698 @default.
• W2809918268 hasConcept C2780942790 @default.
• W2809918268 hasConcept C2781128166 @default.
• W2809918268 hasConcept C2910196583 @default.
• W2809918268 hasConcept C54355233 @default.
• W2809918268 hasConcept C71924100 @default.
• W2809918268 hasConcept C86803240 @default.
• W2809918268 hasConcept C8891405 @default.
• W2809918268 hasConceptScore W2809918268C126322002 @default.
• W2809918268 hasConceptScore W2809918268C159654299 @default.
• W2809918268 hasConceptScore W2809918268C162834538 @default.
• W2809918268 hasConceptScore W2809918268C163764329 @default.
• W2809918268 hasConceptScore W2809918268C172680121 @default.
• W2809918268 hasConceptScore W2809918268C203014093 @default.
• W2809918268 hasConceptScore W2809918268C2775915377 @default.
• W2809918268 hasConceptScore W2809918268C2776912625 @default.
• W2809918268 hasConceptScore W2809918268C2777385706 @default.
• W2809918268 hasConceptScore W2809918268C2779075594 @default.
• W2809918268 hasConceptScore W2809918268C2779134260 @default.
• W2809918268 hasConceptScore W2809918268C2779234561 @default.
• W2809918268 hasConceptScore W2809918268C2780130043 @default.
• W2809918268 hasConceptScore W2809918268C2780194698 @default.
• W2809918268 hasConceptScore W2809918268C2780942790 @default.
• W2809918268 hasConceptScore W2809918268C2781128166 @default.
• W2809918268 hasConceptScore W2809918268C2910196583 @default.

• next