FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809924114> ?p ?o ?g. }

• W2809924114 abstract "Hepatocellular carcinoma (HCC) is one of the most common types of human tumors, which is characterized by high morbidity and mortality rates. AKT1 transcriptional activity is implicated in HCC initiation and development. In the present study, the effects of rs2494752 single nucleotide polymorphism (SNP) on AKT1 transcriptional activity in the progression of HCC cells were investigated. A case‑control study was analyzed in 1,056 HCC patients and 1,080 healthy individuals using the PCR assay method. Results indicated AKT1 expression levels were up‑regulated in HCC tissue compared to adjacent normal tissues. Furthermore, a higher frequency of AKT rs2494752 AG and AA genotypes were observed in HCC cases (P=0.0046). Gene polymorphism identified C and T alleles were frequency in HCC patients compared to healthy individuals. Individuals harboring AKT rs2494752 AG/AA genotype had a vital increased susceptibility to HCC in the dominant model (P=0.0028). In addition, AKT1 rs2494752 GG genotype showed an increasing of AKT1 promoter activity determined by the luciferase assay. Furthermore, it was demonstrated that AKT1 rs2494752 GG and C polymorphism was more aggressive than other AKT1 rs2494752 cancer cells. Moreover, AKT1 rs2494752 GG markedly increased rates of response to NCT chemotherapy. Additionally, results revealed that AKT1 rs2494752 GG and C increased the risk factors of HCC. In conclusion, these results indicate that AKT1 rs2494752 polymorphisms may be regarded as a candidate gene in assessing the susceptibility, metastasis and responses to chemotherapy in the progression of hepatocellular carcinoma." @default.
• W2809924114 created "2018-07-10" @default.
• W2809924114 creator A5000432967 @default.
• W2809924114 creator A5024994504 @default.
• W2809924114 creator A5049804513 @default.
• W2809924114 date "2018-07-02" @default.
• W2809924114 modified "2023-10-12" @default.
• W2809924114 title "Association between AKT rs2494752 single nucleotide polymorphism and the risk of metastasis in hepatocellular carcinoma" @default.
• W2809924114 cites W1498590527 @default.
• W2809924114 cites W1568010007 @default.
• W2809924114 cites W1577279214 @default.
• W2809924114 cites W1607755769 @default.
• W2809924114 cites W1666371634 @default.
• W2809924114 cites W1732964060 @default.
• W2809924114 cites W1861546069 @default.
• W2809924114 cites W1897080898 @default.
• W2809924114 cites W1899434656 @default.
• W2809924114 cites W1942246373 @default.
• W2809924114 cites W1946423182 @default.
• W2809924114 cites W1978992622 @default.
• W2809924114 cites W1982229026 @default.
• W2809924114 cites W2030029800 @default.
• W2809924114 cites W2045836176 @default.
• W2809924114 cites W2070245532 @default.
• W2809924114 cites W2075175079 @default.
• W2809924114 cites W2107277218 @default.
• W2809924114 cites W2110462773 @default.
• W2809924114 cites W2120081201 @default.
• W2809924114 cites W2122024279 @default.
• W2809924114 cites W2135607846 @default.
• W2809924114 cites W2138166063 @default.
• W2809924114 cites W2192080449 @default.
• W2809924114 cites W2281751957 @default.
• W2809924114 cites W2295880275 @default.
• W2809924114 cites W2302184756 @default.
• W2809924114 cites W2463540776 @default.
• W2809924114 cites W2529646902 @default.
• W2809924114 cites W2534134632 @default.
• W2809924114 cites W2590380080 @default.
• W2809924114 cites W2607343926 @default.
• W2809924114 cites W2616998720 @default.
• W2809924114 cites W2728373682 @default.
• W2809924114 cites W885837816 @default.
• W2809924114 cites W1718568462 @default.
• W2809924114 cites W2131863386 @default.
• W2809924114 cites W2156325447 @default.
• W2809924114 doi "https://doi.org/10.3892/ol.2018.9060" @default.
• W2809924114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6096108" @default.
• W2809924114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30127980" @default.
• W2809924114 hasPublicationYear "2018" @default.
• W2809924114 type Work @default.
• W2809924114 sameAs 2809924114 @default.
• W2809924114 citedByCount "2" @default.
• W2809924114 countsByYear W28099241142023 @default.
• W2809924114 crossrefType "journal-article" @default.
• W2809924114 hasAuthorship W2809924114A5000432967 @default.
• W2809924114 hasAuthorship W2809924114A5024994504 @default.
• W2809924114 hasAuthorship W2809924114A5049804513 @default.
• W2809924114 hasBestOaLocation W28099241141 @default.
• W2809924114 hasConcept C104317684 @default.
• W2809924114 hasConcept C121608353 @default.
• W2809924114 hasConcept C126322002 @default.
• W2809924114 hasConcept C135763542 @default.
• W2809924114 hasConcept C139275648 @default.
• W2809924114 hasConcept C143998085 @default.
• W2809924114 hasConcept C153209595 @default.
• W2809924114 hasConcept C154137905 @default.
• W2809924114 hasConcept C180754005 @default.
• W2809924114 hasConcept C190283241 @default.
• W2809924114 hasConcept C2778019345 @default.
• W2809924114 hasConcept C2779013556 @default.
• W2809924114 hasConcept C2781018059 @default.
• W2809924114 hasConcept C29537977 @default.
• W2809924114 hasConcept C502942594 @default.
• W2809924114 hasConcept C54355233 @default.
• W2809924114 hasConcept C71924100 @default.
• W2809924114 hasConcept C75217442 @default.
• W2809924114 hasConcept C86803240 @default.
• W2809924114 hasConceptScore W2809924114C104317684 @default.
• W2809924114 hasConceptScore W2809924114C121608353 @default.
• W2809924114 hasConceptScore W2809924114C126322002 @default.
• W2809924114 hasConceptScore W2809924114C135763542 @default.
• W2809924114 hasConceptScore W2809924114C139275648 @default.
• W2809924114 hasConceptScore W2809924114C143998085 @default.
• W2809924114 hasConceptScore W2809924114C153209595 @default.
• W2809924114 hasConceptScore W2809924114C154137905 @default.
• W2809924114 hasConceptScore W2809924114C180754005 @default.
• W2809924114 hasConceptScore W2809924114C190283241 @default.
• W2809924114 hasConceptScore W2809924114C2778019345 @default.
• W2809924114 hasConceptScore W2809924114C2779013556 @default.
• W2809924114 hasConceptScore W2809924114C2781018059 @default.
• W2809924114 hasConceptScore W2809924114C29537977 @default.
• W2809924114 hasConceptScore W2809924114C502942594 @default.
• W2809924114 hasConceptScore W2809924114C54355233 @default.
• W2809924114 hasConceptScore W2809924114C71924100 @default.
• W2809924114 hasConceptScore W2809924114C75217442 @default.
• W2809924114 hasConceptScore W2809924114C86803240 @default.
• W2809924114 hasLocation W28099241141 @default.
• W2809924114 hasLocation W28099241142 @default.
• W2809924114 hasLocation W28099241143 @default.

• next