Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809927900> ?p ?o ?g. }
- W2809927900 abstract "Summary ATP synthase (F 1 F o ) synthesizes daily our body’s weight in ATP, whose production-rate can be transiently increased several-fold. Using purified mammalian F 1 F o -reconstituted proteoliposomes and isolated mitochondria, we show that F 1 F o utilizes both H + - and K + -transport (because of >10 6 -fold K + excess vs H + ) to drive ATP synthesis with the H + :K + permeability of ~10 6 :1. F 1 F o can be upregulated by endogenous survival-related proteins (Bcl-xL, Mcl-1) and synthetic molecules (diazoxide, pinacidil) to increase its chemo-mechanical efficiency via IF 1 . Increasing K + - and H + -driven ATP synthesis enables F 1 F o to operate as a primary mitochondrial K + -uniporter regulating energy supply-demand matching, and as the recruitable mitochondrial K ATP -channel that can limit ischemia-reperfusion injury. Isolated mitochondria in the presence of K + can sustain ~3.5-fold higher ATP-synthesis-flux (vs K + absence) driven by a 2.7:1 K + :H + stoichiometry with unaltered OxPhos coupling. Excellent agreement between F 1 F o single-molecule and intact-mitochondria experiments is consistent with K + -transport through ATP synthase driving a major fraction of ATP synthesis." @default.
- W2809927900 created "2018-07-10" @default.
- W2809927900 creator A5005789848 @default.
- W2809927900 creator A5020291322 @default.
- W2809927900 creator A5029031647 @default.
- W2809927900 creator A5040194870 @default.
- W2809927900 creator A5040997437 @default.
- W2809927900 creator A5049573849 @default.
- W2809927900 creator A5064857408 @default.
- W2809927900 creator A5067692998 @default.
- W2809927900 creator A5075954545 @default.
- W2809927900 creator A5076889486 @default.
- W2809927900 creator A5081151780 @default.
- W2809927900 creator A5083366327 @default.
- W2809927900 date "2018-06-26" @default.
- W2809927900 modified "2023-09-26" @default.
- W2809927900 title "ATP synthase K+- and H+-flux drive ATP synthesis and enable mitochondrial K+-uniporter function" @default.
- W2809927900 cites W1508862796 @default.
- W2809927900 cites W1964051078 @default.
- W2809927900 cites W1964126982 @default.
- W2809927900 cites W1964976203 @default.
- W2809927900 cites W1971006437 @default.
- W2809927900 cites W1974096051 @default.
- W2809927900 cites W1974349185 @default.
- W2809927900 cites W1974809682 @default.
- W2809927900 cites W1975805475 @default.
- W2809927900 cites W1977566044 @default.
- W2809927900 cites W1984111162 @default.
- W2809927900 cites W1987385157 @default.
- W2809927900 cites W1992196716 @default.
- W2809927900 cites W1993591148 @default.
- W2809927900 cites W2007939778 @default.
- W2809927900 cites W2018611729 @default.
- W2809927900 cites W2021806117 @default.
- W2809927900 cites W2024104987 @default.
- W2809927900 cites W2024596511 @default.
- W2809927900 cites W2026945507 @default.
- W2809927900 cites W2029530574 @default.
- W2809927900 cites W2045839655 @default.
- W2809927900 cites W2050625847 @default.
- W2809927900 cites W2052618584 @default.
- W2809927900 cites W2060113588 @default.
- W2809927900 cites W2062821451 @default.
- W2809927900 cites W2063250341 @default.
- W2809927900 cites W2064598149 @default.
- W2809927900 cites W2071950147 @default.
- W2809927900 cites W2074033410 @default.
- W2809927900 cites W2074570665 @default.
- W2809927900 cites W2075422273 @default.
- W2809927900 cites W2076598575 @default.
- W2809927900 cites W2081589037 @default.
- W2809927900 cites W2081699014 @default.
- W2809927900 cites W2088054367 @default.
- W2809927900 cites W2090734611 @default.
- W2809927900 cites W2095188039 @default.
- W2809927900 cites W2109654959 @default.
- W2809927900 cites W2114429287 @default.
- W2809927900 cites W2116444561 @default.
- W2809927900 cites W2127322768 @default.
- W2809927900 cites W2127849030 @default.
- W2809927900 cites W2129601242 @default.
- W2809927900 cites W2130377301 @default.
- W2809927900 cites W2133838366 @default.
- W2809927900 cites W2134413058 @default.
- W2809927900 cites W2134506141 @default.
- W2809927900 cites W2135314348 @default.
- W2809927900 cites W2137564359 @default.
- W2809927900 cites W2157659024 @default.
- W2809927900 cites W2158552404 @default.
- W2809927900 cites W2160086057 @default.
- W2809927900 cites W2160331476 @default.
- W2809927900 cites W2161570633 @default.
- W2809927900 cites W2164825141 @default.
- W2809927900 cites W2166398149 @default.
- W2809927900 cites W2190690918 @default.
- W2809927900 cites W2194772685 @default.
- W2809927900 cites W2257586683 @default.
- W2809927900 cites W2318979767 @default.
- W2809927900 cites W4237179543 @default.
- W2809927900 doi "https://doi.org/10.1101/355776" @default.
- W2809927900 hasPublicationYear "2018" @default.
- W2809927900 type Work @default.
- W2809927900 sameAs 2809927900 @default.
- W2809927900 citedByCount "3" @default.
- W2809927900 countsByYear W28099279002021 @default.
- W2809927900 countsByYear W28099279002022 @default.
- W2809927900 crossrefType "posted-content" @default.
- W2809927900 hasAuthorship W2809927900A5005789848 @default.
- W2809927900 hasAuthorship W2809927900A5020291322 @default.
- W2809927900 hasAuthorship W2809927900A5029031647 @default.
- W2809927900 hasAuthorship W2809927900A5040194870 @default.
- W2809927900 hasAuthorship W2809927900A5040997437 @default.
- W2809927900 hasAuthorship W2809927900A5049573849 @default.
- W2809927900 hasAuthorship W2809927900A5064857408 @default.
- W2809927900 hasAuthorship W2809927900A5067692998 @default.
- W2809927900 hasAuthorship W2809927900A5075954545 @default.
- W2809927900 hasAuthorship W2809927900A5076889486 @default.
- W2809927900 hasAuthorship W2809927900A5081151780 @default.
- W2809927900 hasAuthorship W2809927900A5083366327 @default.
- W2809927900 hasBestOaLocation W28099279001 @default.