FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809937013> ?p ?o ?g. }

• W2809937013 abstract "The human bone marrow (BM) gives rise to all distinct blood cell lineages, including CD1c+ (cDC2) and CD141+ (cDC1) myeloid dendritic cells (DC) and monocytes. These cell subsets are also present in peripheral blood (PB) and lymphoid tissues. However, the difference between the BM and PB compartment in terms of differentiation state and immunological role of DC is not yet known. The BM may represent both a site for development as well as a possible effector site and so far, little is known in this light with respect to different DC subsets. Using genome-wide transcriptional profiling we found clear differences between the BM and PB compartment and a location-dependent clustering for cDC2 and cDC1 was demonstrated. DC subsets from BM clustered together and separate from the corresponding subsets from PB, which similarly formed a cluster. In BM, a common proliferating and immature differentiating state was observed for the two DC subsets, whereas DC from the PB showed a more immune-activated mature profile. In contrast, BM-derived slan+ non-classical monocytes were closely related to their PB counterparts and not to DC subsets, implying a homogenous prolife irrespective of anatomical localization. Additional functional tests confirmed these transcriptional findings. DC-like functions were prominently exhibited by PB DC. They surpassed BM DC in maturation capacity, cytokine production, and induction of CD4+ and CD8+ T cell proliferation. This first study on myeloid DC in healthy human BM offers new information on steady state DC biology and could potentially serve as a starting point for further research on these immune cells in healthy conditions as well as in diseases." @default.
• W2809937013 created "2018-07-10" @default.
• W2809937013 creator A5002354967 @default.
• W2809937013 creator A5013460374 @default.
• W2809937013 creator A5031160909 @default.
• W2809937013 creator A5040422426 @default.
• W2809937013 creator A5048532379 @default.
• W2809937013 creator A5053105927 @default.
• W2809937013 creator A5090840670 @default.
• W2809937013 creator A5043590900 @default.
• W2809937013 date "2018-07-16" @default.
• W2809937013 modified "2023-10-16" @default.
• W2809937013 title "Human Bone Marrow-Derived Myeloid Dendritic Cells Show an Immature Transcriptional and Functional Profile Compared to Their Peripheral Blood Counterparts and Separate from Slan+ Non-Classical Monocytes" @default.
• W2809937013 cites W1559380665 @default.
• W2809937013 cites W1772469811 @default.
• W2809937013 cites W1964464283 @default.
• W2809937013 cites W1968848897 @default.
• W2809937013 cites W1970573066 @default.
• W2809937013 cites W1975463463 @default.
• W2809937013 cites W1990196345 @default.
• W2809937013 cites W1990362267 @default.
• W2809937013 cites W1992439632 @default.
• W2809937013 cites W1992750664 @default.
• W2809937013 cites W2000260197 @default.
• W2809937013 cites W2016783460 @default.
• W2809937013 cites W2017239249 @default.
• W2809937013 cites W2025262617 @default.
• W2809937013 cites W2025635725 @default.
• W2809937013 cites W2036138390 @default.
• W2809937013 cites W2039657697 @default.
• W2809937013 cites W2043395626 @default.
• W2809937013 cites W2048793063 @default.
• W2809937013 cites W2054581136 @default.
• W2809937013 cites W2056461632 @default.
• W2809937013 cites W2060405001 @default.
• W2809937013 cites W2064440157 @default.
• W2809937013 cites W2076380163 @default.
• W2809937013 cites W2077752679 @default.
• W2809937013 cites W2078572489 @default.
• W2809937013 cites W2084407030 @default.
• W2809937013 cites W2087508704 @default.
• W2809937013 cites W2090685407 @default.
• W2809937013 cites W2099697271 @default.
• W2809937013 cites W2100712109 @default.
• W2809937013 cites W2100820895 @default.
• W2809937013 cites W2108886544 @default.
• W2809937013 cites W2113779347 @default.
• W2809937013 cites W2113896298 @default.
• W2809937013 cites W2120315525 @default.
• W2809937013 cites W2125615007 @default.
• W2809937013 cites W2126705611 @default.
• W2809937013 cites W2127144270 @default.
• W2809937013 cites W2133350434 @default.
• W2809937013 cites W2138165953 @default.
• W2809937013 cites W2139868023 @default.
• W2809937013 cites W2142084466 @default.
• W2809937013 cites W2151369808 @default.
• W2809937013 cites W2155792963 @default.
• W2809937013 cites W2160864702 @default.
• W2809937013 cites W2168028214 @default.
• W2809937013 cites W2168401979 @default.
• W2809937013 cites W2169324807 @default.
• W2809937013 cites W2200454099 @default.
• W2809937013 cites W2318864201 @default.
• W2809937013 cites W2408730462 @default.
• W2809937013 cites W2556671754 @default.
• W2809937013 cites W2562450957 @default.
• W2809937013 cites W2738413509 @default.
• W2809937013 cites W78744612 @default.
• W2809937013 cites W880640307 @default.
• W2809937013 doi "https://doi.org/10.3389/fimmu.2018.01619" @default.
• W2809937013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6055354" @default.
• W2809937013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30061890" @default.
• W2809937013 hasPublicationYear "2018" @default.
• W2809937013 type Work @default.
• W2809937013 sameAs 2809937013 @default.
• W2809937013 citedByCount "15" @default.
• W2809937013 countsByYear W28099370132019 @default.
• W2809937013 countsByYear W28099370132020 @default.
• W2809937013 countsByYear W28099370132021 @default.
• W2809937013 countsByYear W28099370132022 @default.
• W2809937013 countsByYear W28099370132023 @default.
• W2809937013 crossrefType "journal-article" @default.
• W2809937013 hasAuthorship W2809937013A5002354967 @default.
• W2809937013 hasAuthorship W2809937013A5013460374 @default.
• W2809937013 hasAuthorship W2809937013A5031160909 @default.
• W2809937013 hasAuthorship W2809937013A5040422426 @default.
• W2809937013 hasAuthorship W2809937013A5043590900 @default.
• W2809937013 hasAuthorship W2809937013A5048532379 @default.
• W2809937013 hasAuthorship W2809937013A5053105927 @default.
• W2809937013 hasAuthorship W2809937013A5090840670 @default.
• W2809937013 hasBestOaLocation W28099370131 @default.
• W2809937013 hasConcept C111368507 @default.
• W2809937013 hasConcept C127313418 @default.
• W2809937013 hasConcept C167672396 @default.
• W2809937013 hasConcept C203014093 @default.
• W2809937013 hasConcept C203635412 @default.
• W2809937013 hasConcept C2778170410 @default.
• W2809937013 hasConcept C2779282312 @default.
• W2809937013 hasConcept C2780007613 @default.

• next