Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809941199> ?p ?o ?g. }
- W2809941199 abstract "Interleukin-1β (IL-1β) plays a crucial role in mediating inflammation and innate immunity response in the central nervous system. Death-associated protein kinase 1 (DAPK1) was shown to be involved in several cellular processes. Here, we investigated the effects of DAPK1 on IL-1β production in microglial cells. We used a combination of in vitro (Bv2 microglial cell cultures) and in vivo (mice injected with amyloid-β (Aβ)) techniques to address the role of caspase-1 activation in release of IL-1β. DAPK1 involvement was postulated through genetic approaches and pharmacological blockade of this enzyme. We found that Aβ25-35 stimulation induced IL-1β production and caspase-1 activation in LPS-primed Bv2 cells and mice. DAPK1 knockdown and catalytic activity inhibition reduced IL-1β maturation and caspase-1 activation, nevertheless, DAPK1 overexpression attenuated these effects. Aβ25-35-induced lysosomal cathepsin B leakage was required for DAPK1 activation. Furthermore, repeated DAPK1 inhibitor treatment ameliorated the memory impairment in Aβ25-35-injected mice. Taken together, our findings suggest that DAPK1 facilitates Aβ25-35-induced IL-1β production through regulating caspase-1 activation in microglial cells." @default.
- W2809941199 created "2018-07-10" @default.
- W2809941199 creator A5003409121 @default.
- W2809941199 creator A5008729488 @default.
- W2809941199 creator A5010971998 @default.
- W2809941199 creator A5017353282 @default.
- W2809941199 creator A5049943257 @default.
- W2809941199 creator A5063225106 @default.
- W2809941199 creator A5067893036 @default.
- W2809941199 creator A5074120154 @default.
- W2809941199 creator A5091039278 @default.
- W2809941199 date "2018-07-02" @default.
- W2809941199 modified "2023-10-14" @default.
- W2809941199 title "Death-associated protein kinase 1 mediates interleukin-1β production through regulating inlfammasome activation in Bv2 microglial cells and mice" @default.
- W2809941199 cites W1733395966 @default.
- W2809941199 cites W1755191730 @default.
- W2809941199 cites W1841850981 @default.
- W2809941199 cites W1879825028 @default.
- W2809941199 cites W1901729201 @default.
- W2809941199 cites W1963721982 @default.
- W2809941199 cites W1964012705 @default.
- W2809941199 cites W1964917807 @default.
- W2809941199 cites W1964944610 @default.
- W2809941199 cites W1972483153 @default.
- W2809941199 cites W1974966491 @default.
- W2809941199 cites W1979033214 @default.
- W2809941199 cites W1981649246 @default.
- W2809941199 cites W1992544868 @default.
- W2809941199 cites W1993976394 @default.
- W2809941199 cites W1994682164 @default.
- W2809941199 cites W2003704824 @default.
- W2809941199 cites W2003988488 @default.
- W2809941199 cites W2007631668 @default.
- W2809941199 cites W2008326600 @default.
- W2809941199 cites W2012482368 @default.
- W2809941199 cites W2019495623 @default.
- W2809941199 cites W2020834255 @default.
- W2809941199 cites W2025877033 @default.
- W2809941199 cites W2029781694 @default.
- W2809941199 cites W2030410023 @default.
- W2809941199 cites W2035644823 @default.
- W2809941199 cites W2041497934 @default.
- W2809941199 cites W2043458530 @default.
- W2809941199 cites W2048224964 @default.
- W2809941199 cites W2063563698 @default.
- W2809941199 cites W2065050364 @default.
- W2809941199 cites W2074259977 @default.
- W2809941199 cites W2074472141 @default.
- W2809941199 cites W2082317154 @default.
- W2809941199 cites W2085262263 @default.
- W2809941199 cites W2087243986 @default.
- W2809941199 cites W2087321410 @default.
- W2809941199 cites W2090474831 @default.
- W2809941199 cites W2112215250 @default.
- W2809941199 cites W2113485094 @default.
- W2809941199 cites W2119098586 @default.
- W2809941199 cites W2121491039 @default.
- W2809941199 cites W2126384811 @default.
- W2809941199 cites W2130574221 @default.
- W2809941199 cites W2133546253 @default.
- W2809941199 cites W2145158408 @default.
- W2809941199 cites W2148914027 @default.
- W2809941199 cites W2150727304 @default.
- W2809941199 cites W2284643044 @default.
- W2809941199 cites W2291628530 @default.
- W2809941199 cites W2417570742 @default.
- W2809941199 cites W2476430065 @default.
- W2809941199 cites W2536783646 @default.
- W2809941199 cites W2620787577 @default.
- W2809941199 cites W4211021876 @default.
- W2809941199 cites W582182564 @default.
- W2809941199 doi "https://doi.org/10.1038/s41598-018-27842-y" @default.
- W2809941199 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6028446" @default.
- W2809941199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29967321" @default.
- W2809941199 hasPublicationYear "2018" @default.
- W2809941199 type Work @default.
- W2809941199 sameAs 2809941199 @default.
- W2809941199 citedByCount "12" @default.
- W2809941199 countsByYear W28099411992020 @default.
- W2809941199 countsByYear W28099411992021 @default.
- W2809941199 countsByYear W28099411992022 @default.
- W2809941199 countsByYear W28099411992023 @default.
- W2809941199 crossrefType "journal-article" @default.
- W2809941199 hasAuthorship W2809941199A5003409121 @default.
- W2809941199 hasAuthorship W2809941199A5008729488 @default.
- W2809941199 hasAuthorship W2809941199A5010971998 @default.
- W2809941199 hasAuthorship W2809941199A5017353282 @default.
- W2809941199 hasAuthorship W2809941199A5049943257 @default.
- W2809941199 hasAuthorship W2809941199A5063225106 @default.
- W2809941199 hasAuthorship W2809941199A5067893036 @default.
- W2809941199 hasAuthorship W2809941199A5074120154 @default.
- W2809941199 hasAuthorship W2809941199A5091039278 @default.
- W2809941199 hasBestOaLocation W28099411991 @default.
- W2809941199 hasConcept C139964883 @default.
- W2809941199 hasConcept C169760540 @default.
- W2809941199 hasConcept C173396325 @default.
- W2809941199 hasConcept C184235292 @default.
- W2809941199 hasConcept C190283241 @default.
- W2809941199 hasConcept C203014093 @default.
- W2809941199 hasConcept C24998067 @default.