FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809962140> ?p ?o ?g. }

• W2809962140 abstract "Immune checkpoint inhibition (ICI) with anti-CTLA-4 and/or anti-PD-1 antibodies is standard treatment for metastatic melanoma. Anti-PD-1 (pembrolizumab, nivolumab) and anti-PD-L1 antibodies (atezolizumab, durvalumab, and avelumab) have been approved for treatment of several other advanced malignancies, including non-small-cell lung cancer (NSCLC); renal cell, and urothelial carcinoma; head and neck cancer; gastric, hepatocellular, and Merkel-cell carcinoma; and classical Hodgkin lymphoma. In some of these malignancies approval was based on the detection of biomarkers such as PD-L1 expression or high microsatellite instability.We review the current status of prognostic and predictive biomarkers used in ICI for melanoma and other malignancies. We include clinical, tissue, blood, and stool biomarkers, as well as imaging biomarkers.Several biomarkers have been studied in ICI for metastatic melanoma. In clinical practice, pre-treatment tumor burden measured by means of imaging and serum lactate dehydrogenase level is already being used to estimate the likelihood of effective ICI treatment. In peripheral blood, the number of different immune cell types, such as lymphocytes, neutrophils, and eosinophils, as well as different soluble factors, have been correlated with clinical outcome. For intra-tumoral biomarkers, expression of the PD-1 ligand PD-L1 has been found to be of some predictive value for anti-PD-1-directed therapy for NSCLC and melanoma. A high mutational load, particularly when accompanied by neoantigens, seems to facilitate immune response and correlates with patient survival for all entities treated by use of ICI. Tumor microenvironment also seems to be of major importance. Interestingly, even the gut microbiome has been found to correlate with response to ICI, most likely through immuno-stimulatory effects of distinct bacteria. New imaging biomarkers, e.g., for PET, and magnetic resonance imaging are also being investigated, and results suggest they will make early prediction of patient response possible.Several promising results are available regarding possible biomarkers for response to ICI, which need to be validated in large clinical trials. A better understanding of how ICI works will enable the development of biomarkers that can predict the response of individual patients." @default.
• W2809962140 created "2018-07-10" @default.
• W2809962140 creator A5019157865 @default.
• W2809962140 creator A5067776208 @default.
• W2809962140 date "2018-06-28" @default.
• W2809962140 modified "2023-10-14" @default.
• W2809962140 title "Biomarkers for Clinical Benefit of Immune Checkpoint Inhibitor Treatment—A Review From the Melanoma Perspective and Beyond" @default.
• W2809962140 cites W1488069418 @default.
• W2809962140 cites W1525097199 @default.
• W2809962140 cites W1530499164 @default.
• W2809962140 cites W1534815147 @default.
• W2809962140 cites W1809627231 @default.
• W2809962140 cites W1870093969 @default.
• W2809962140 cites W1885459371 @default.
• W2809962140 cites W1916387106 @default.
• W2809962140 cites W1936755024 @default.
• W2809962140 cites W1940241680 @default.
• W2809962140 cites W1965215390 @default.
• W2809962140 cites W1972755885 @default.
• W2809962140 cites W1982488143 @default.
• W2809962140 cites W1984273269 @default.
• W2809962140 cites W1990675339 @default.
• W2809962140 cites W2019607817 @default.
• W2809962140 cites W2020102380 @default.
• W2809962140 cites W2036195858 @default.
• W2809962140 cites W2038914273 @default.
• W2809962140 cites W2039123767 @default.
• W2809962140 cites W2045883564 @default.
• W2809962140 cites W2049553585 @default.
• W2809962140 cites W2054679436 @default.
• W2809962140 cites W2056199226 @default.
• W2809962140 cites W2056816700 @default.
• W2809962140 cites W2060473360 @default.
• W2809962140 cites W2072429991 @default.
• W2809962140 cites W2080435444 @default.
• W2809962140 cites W2086891934 @default.
• W2809962140 cites W2089536793 @default.
• W2809962140 cites W2100158834 @default.
• W2809962140 cites W2103277177 @default.
• W2809962140 cites W2104347254 @default.
• W2809962140 cites W2105057287 @default.
• W2809962140 cites W2107429737 @default.
• W2809962140 cites W2108549165 @default.
• W2809962140 cites W2109485845 @default.
• W2809962140 cites W2112121482 @default.
• W2809962140 cites W2114031931 @default.
• W2809962140 cites W2118342755 @default.
• W2809962140 cites W2120041024 @default.
• W2809962140 cites W2123363005 @default.
• W2809962140 cites W2124427232 @default.
• W2809962140 cites W2127737941 @default.
• W2809962140 cites W2128035403 @default.
• W2809962140 cites W2131040858 @default.
• W2809962140 cites W2133942235 @default.
• W2809962140 cites W2137074525 @default.
• W2809962140 cites W2137298764 @default.
• W2809962140 cites W2138134458 @default.
• W2809962140 cites W2142300779 @default.
• W2809962140 cites W2143105454 @default.
• W2809962140 cites W2145989336 @default.
• W2809962140 cites W2152897456 @default.
• W2809962140 cites W2153942285 @default.
• W2809962140 cites W2155263737 @default.
• W2809962140 cites W2156353875 @default.
• W2809962140 cites W2160834915 @default.
• W2809962140 cites W2162311181 @default.
• W2809962140 cites W2165456770 @default.
• W2809962140 cites W2166662937 @default.
• W2809962140 cites W2166667372 @default.
• W2809962140 cites W2179179825 @default.
• W2809962140 cites W2181134504 @default.
• W2809962140 cites W2181603179 @default.
• W2809962140 cites W2185075416 @default.
• W2809962140 cites W2198093519 @default.
• W2809962140 cites W2200286273 @default.
• W2809962140 cites W2267367070 @default.
• W2809962140 cites W2270932386 @default.
• W2809962140 cites W2282962877 @default.
• W2809962140 cites W2291298003 @default.
• W2809962140 cites W2293531514 @default.
• W2809962140 cites W2299181842 @default.
• W2809962140 cites W2301707196 @default.
• W2809962140 cites W2324094374 @default.
• W2809962140 cites W2392329487 @default.
• W2809962140 cites W2396214192 @default.
• W2809962140 cites W2396808887 @default.
• W2809962140 cites W2397854274 @default.
• W2809962140 cites W2405335500 @default.
• W2809962140 cites W2414868979 @default.
• W2809962140 cites W2414977199 @default.
• W2809962140 cites W2465860350 @default.
• W2809962140 cites W2473498748 @default.
• W2809962140 cites W2488330279 @default.
• W2809962140 cites W2497521284 @default.
• W2809962140 cites W2507591048 @default.
• W2809962140 cites W2510686645 @default.
• W2809962140 cites W2512255557 @default.
• W2809962140 cites W2517991741 @default.
• W2809962140 cites W2522277066 @default.
• W2809962140 cites W2523194272 @default.

• next