FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809969369> ?p ?o ?g. }

• W2809969369 endingPage "e0199012" @default.
• W2809969369 startingPage "e0199012" @default.
• W2809969369 abstract "Most breast cancer deaths are caused by metastasis and treatment options beyond radiation and cytotoxic drugs, which have severe side effects, and hormonal treatments, which are or become ineffective for many patients, are urgently needed. This study reanalyzed existing data from three genome-wide association studies (GWAS) using a novel computational biostatistics approach (muGWAS), which had been validated in studies of 600-2000 subjects in epilepsy and autism. MuGWAS jointly analyzes several neighboring single nucleotide polymorphisms while incorporating knowledge about genetics of heritable diseases into the statistical method and about GWAS into the rules for determining adaptive genome-wide significance. Results from three independent GWAS of 1000-2000 subjects each, which were made available under the National Institute of Health's Up For A Challenge (U4C) project, not only confirmed cell-cycle control and receptor/AKT signaling, but, for the first time in breast cancer GWAS, also consistently identified many genes involved in endo-/exocytosis (EEC), most of which had already been observed in functional and expression studies of breast cancer. In particular, the findings include genes that translocate (ATP8A1, ATP8B1, ANO4, ABCA1) and metabolize (AGPAT3, AGPAT4, DGKQ, LPPR1) phospholipids entering the phosphatidylinositol cycle, which controls EEC. These novel findings suggest scavenging phospholipids as a novel intervention to control local spread of cancer, packaging of exosomes (which prepare distant microenvironment for organ-specific metastases), and endocytosis of β1 integrins (which are required for spread of metastatic phenotype and mesenchymal migration of tumor cells). Beta-cyclodextrins (βCD) have already been shown to be effective in in vitro and animal studies of breast cancer, but exhibits cholesterol-related ototoxicity. The smaller alpha-cyclodextrins (αCD) also scavenges phospholipids, but cannot fit cholesterol. An in-vitro study presented here confirms hydroxypropyl (HP)-αCD to be twice as effective as HPβCD against migration of human cells of both receptor negative and estrogen-receptor positive breast cancer. If the previous successful animal studies with βCDs are replicated with the safer and more effective αCDs, clinical trials of adjuvant treatment with αCDs are warranted. Ultimately, all breast cancer are expected to benefit from treatment with HPαCD, but women with triple-negative breast cancer (TNBC) will benefit most, because they have fewer treatment options and their cancer advances more aggressively." @default.
• W2809969369 created "2018-07-10" @default.
• W2809969369 creator A5007773065 @default.
• W2809969369 creator A5040791128 @default.
• W2809969369 creator A5044701800 @default.
• W2809969369 creator A5059683780 @default.
• W2809969369 creator A5065500120 @default.
• W2809969369 creator A5084959889 @default.
• W2809969369 date "2018-07-02" @default.
• W2809969369 modified "2023-09-29" @default.
• W2809969369 title "Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer" @default.
• W2809969369 cites W1551667737 @default.
• W2809969369 cites W1568412294 @default.
• W2809969369 cites W1569533476 @default.
• W2809969369 cites W1598919268 @default.
• W2809969369 cites W1600320669 @default.
• W2809969369 cites W1601681275 @default.
• W2809969369 cites W1637147963 @default.
• W2809969369 cites W1682077723 @default.
• W2809969369 cites W1697337825 @default.
• W2809969369 cites W1772878786 @default.
• W2809969369 cites W1907295175 @default.
• W2809969369 cites W1915712652 @default.
• W2809969369 cites W1950118853 @default.
• W2809969369 cites W1963907646 @default.
• W2809969369 cites W1967976750 @default.
• W2809969369 cites W1968902806 @default.
• W2809969369 cites W1969297227 @default.
• W2809969369 cites W1970358723 @default.
• W2809969369 cites W1972978214 @default.
• W2809969369 cites W1973491533 @default.
• W2809969369 cites W1974342535 @default.
• W2809969369 cites W1979751563 @default.
• W2809969369 cites W1989207936 @default.
• W2809969369 cites W1992203600 @default.
• W2809969369 cites W1996840895 @default.
• W2809969369 cites W1997708663 @default.
• W2809969369 cites W1997947349 @default.
• W2809969369 cites W1998249296 @default.
• W2809969369 cites W2002498072 @default.
• W2809969369 cites W2002630715 @default.
• W2809969369 cites W2004960532 @default.
• W2809969369 cites W2006423274 @default.
• W2809969369 cites W2008577371 @default.
• W2809969369 cites W2009387137 @default.
• W2809969369 cites W2009826571 @default.
• W2809969369 cites W2010854970 @default.
• W2809969369 cites W2013970287 @default.
• W2809969369 cites W2014822965 @default.
• W2809969369 cites W2019872705 @default.
• W2809969369 cites W2022650450 @default.
• W2809969369 cites W2024502310 @default.
• W2809969369 cites W2026462337 @default.
• W2809969369 cites W2029665361 @default.
• W2809969369 cites W2029919331 @default.
• W2809969369 cites W2032338082 @default.
• W2809969369 cites W2033531401 @default.
• W2809969369 cites W2034833395 @default.
• W2809969369 cites W2041953582 @default.
• W2809969369 cites W2043831865 @default.
• W2809969369 cites W2043956016 @default.
• W2809969369 cites W2044339772 @default.
• W2809969369 cites W2044441651 @default.
• W2809969369 cites W2044564729 @default.
• W2809969369 cites W2046243885 @default.
• W2809969369 cites W2049528074 @default.
• W2809969369 cites W2049627892 @default.
• W2809969369 cites W2051818991 @default.
• W2809969369 cites W2054800049 @default.
• W2809969369 cites W2056973997 @default.
• W2809969369 cites W2061708221 @default.
• W2809969369 cites W2066527740 @default.
• W2809969369 cites W2068050893 @default.
• W2809969369 cites W206930963 @default.
• W2809969369 cites W2069971071 @default.
• W2809969369 cites W2073728422 @default.
• W2809969369 cites W2077724220 @default.
• W2809969369 cites W2078636414 @default.
• W2809969369 cites W2079712106 @default.
• W2809969369 cites W2080261305 @default.
• W2809969369 cites W2082536587 @default.
• W2809969369 cites W2091311891 @default.
• W2809969369 cites W2093091016 @default.
• W2809969369 cites W2093934810 @default.
• W2809969369 cites W2094200561 @default.
• W2809969369 cites W2103107569 @default.
• W2809969369 cites W2107281275 @default.
• W2809969369 cites W2110858767 @default.
• W2809969369 cites W2111842731 @default.
• W2809969369 cites W2113784410 @default.
• W2809969369 cites W2116031517 @default.
• W2809969369 cites W2117321286 @default.
• W2809969369 cites W2118911343 @default.
• W2809969369 cites W2120657441 @default.
• W2809969369 cites W2123257343 @default.
• W2809969369 cites W2132559433 @default.
• W2809969369 cites W2134404056 @default.
• W2809969369 cites W2135665336 @default.

• next