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- W2809969527 abstract "MicroRNAs (miRNAs) are small non-coding RNA molecules that are involved in post-transcriptional gene expression. In human CLL cancers and prostate cancer, the miRs that are residing in the same polycistronicRNA such as miR-15a and miR-16-1 are deleted. These miRs inhibit cell proliferation, tumorigenecity and induce apoptosis by targeting key genes such as BCL2, CCND1, MCL1 and WNT3A genes. Studies have found the genomic losses and as well as epigenetic modulations via HDAC inhibition and histone methylation regulate the miR-15/16 gene expression. HDAC inhibitors such as trichostatin A (TSA) and sodium butyrate caused an increase in the expression of miR-15a/16-1 via chromatin epigenetic modulation at Dleu2/miR-15a/16-1 promoter. MiR-15a/16-1-TP53 feedback circuitry, in which p53 directly transactivates miR-15a/16-1 promoter, while miR-15a/16-1 cluster targets TP53 expression regulate the cellular processes such as cell proliferation and apoptosis. These miRs have a huge potential in cancer therapeutics against different types of cancers such as hepatoma, ovarian cancer, and neuroblastoma. The present study demonstrates the role of these microRNAs on various cellular processes such as cell viability, cell-cycle, EMT, drug-resistance, cancer-stemness, angiogenesis, and apoptosis. This review summarizes the functions, epigenetic modulation, clinical relevance and potential of miRNA-based therapeutics against various cancers." @default.
- W2809969527 created "2018-07-10" @default.
- W2809969527 creator A5012840594 @default.
- W2809969527 date "2018-09-01" @default.
- W2809969527 modified "2023-10-16" @default.
- W2809969527 title "Functions and epigenetic aspects of miR-15/16: Possible future cancer therapeutics" @default.
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