Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809971085> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2809971085 endingPage "10" @default.
- W2809971085 startingPage "3" @default.
- W2809971085 abstract "The search for biomarkers to aid in the diagnosis and prognosis of psychiatric conditions and predict response to treatment is a focus of twenty-first century medicine. The current lack of biomarkers in routine use is attributable in part to the existing way mental health conditions are diagnosed, being based upon descriptions of symptoms rather than causal biological evidence. New ways of conceptualizing mental health disorders together with the enormous advances in genetic, epidemiological, and neuroscience research are informing the brain circuits and physiological mechanisms underpinning behavioural constructs that cut across current diagnostic DSM-5 categories. Combining these advances with ‘Big Data’, analytical approaches offer new opportunities for biomarker development. Here we provide an introductory perspective to this volume, highlighting methodological strategies for biomarker identification; ranging from stem cells, immune mechanisms, genomics, imaging, network science to cognition. Thereafter we emphasize key points made by contributors on affective disorders, psychosis, schizophrenia, and autism spectrum disorder. An underlying theme is how preclinical and clinical research are informing biomarker development and the importance of forward and reverse translation approaches. In considering the exploitation of biomarkers we note that there is a timely opportunity to improve clinical trial design informed by patient ‘biological’ and ‘psychological’ phenotype. This has the potential to reinvigorate drug development and clinical trials in psychiatry. In conclusion, we are poised to move from the descriptive and discovery phase to one where biomarker panels can be evaluated in real-life cohorts. This will necessitate resources for large-scale collaborative efforts worldwide. Ultimately this will lead to new interventions and personalized medicines and transform our ability to prevent illness onset and treat complex psychiatric disorders more effectively." @default.
- W2809971085 created "2018-07-10" @default.
- W2809971085 creator A5012211954 @default.
- W2809971085 creator A5048212348 @default.
- W2809971085 date "2018-01-01" @default.
- W2809971085 modified "2023-10-10" @default.
- W2809971085 title "Biomarkers in Neuropsychiatry: A Prospect for the Twenty-First Century?" @default.
- W2809971085 cites W2058880092 @default.
- W2809971085 cites W2071095445 @default.
- W2809971085 cites W2125700525 @default.
- W2809971085 cites W2795480149 @default.
- W2809971085 cites W2795778859 @default.
- W2809971085 cites W2795927640 @default.
- W2809971085 cites W2795954799 @default.
- W2809971085 cites W2796118731 @default.
- W2809971085 cites W2800760914 @default.
- W2809971085 cites W2801687592 @default.
- W2809971085 cites W2802083779 @default.
- W2809971085 cites W2802465634 @default.
- W2809971085 cites W2803332209 @default.
- W2809971085 cites W2806028004 @default.
- W2809971085 cites W2884440057 @default.
- W2809971085 doi "https://doi.org/10.1007/7854_2018_58" @default.
- W2809971085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29967998" @default.
- W2809971085 hasPublicationYear "2018" @default.
- W2809971085 type Work @default.
- W2809971085 sameAs 2809971085 @default.
- W2809971085 citedByCount "19" @default.
- W2809971085 countsByYear W28099710852018 @default.
- W2809971085 countsByYear W28099710852019 @default.
- W2809971085 countsByYear W28099710852020 @default.
- W2809971085 countsByYear W28099710852021 @default.
- W2809971085 countsByYear W28099710852022 @default.
- W2809971085 countsByYear W28099710852023 @default.
- W2809971085 crossrefType "book-chapter" @default.
- W2809971085 hasAuthorship W2809971085A5012211954 @default.
- W2809971085 hasAuthorship W2809971085A5048212348 @default.
- W2809971085 hasBestOaLocation W28099710852 @default.
- W2809971085 hasConcept C104317684 @default.
- W2809971085 hasConcept C116834253 @default.
- W2809971085 hasConcept C118552586 @default.
- W2809971085 hasConcept C124535831 @default.
- W2809971085 hasConcept C128544194 @default.
- W2809971085 hasConcept C134011695 @default.
- W2809971085 hasConcept C142724271 @default.
- W2809971085 hasConcept C15744967 @default.
- W2809971085 hasConcept C185592680 @default.
- W2809971085 hasConcept C2776412080 @default.
- W2809971085 hasConcept C2780035454 @default.
- W2809971085 hasConcept C2781197716 @default.
- W2809971085 hasConcept C46111723 @default.
- W2809971085 hasConcept C55493867 @default.
- W2809971085 hasConcept C59822182 @default.
- W2809971085 hasConcept C64903051 @default.
- W2809971085 hasConcept C71924100 @default.
- W2809971085 hasConcept C86803240 @default.
- W2809971085 hasConceptScore W2809971085C104317684 @default.
- W2809971085 hasConceptScore W2809971085C116834253 @default.
- W2809971085 hasConceptScore W2809971085C118552586 @default.
- W2809971085 hasConceptScore W2809971085C124535831 @default.
- W2809971085 hasConceptScore W2809971085C128544194 @default.
- W2809971085 hasConceptScore W2809971085C134011695 @default.
- W2809971085 hasConceptScore W2809971085C142724271 @default.
- W2809971085 hasConceptScore W2809971085C15744967 @default.
- W2809971085 hasConceptScore W2809971085C185592680 @default.
- W2809971085 hasConceptScore W2809971085C2776412080 @default.
- W2809971085 hasConceptScore W2809971085C2780035454 @default.
- W2809971085 hasConceptScore W2809971085C2781197716 @default.
- W2809971085 hasConceptScore W2809971085C46111723 @default.
- W2809971085 hasConceptScore W2809971085C55493867 @default.
- W2809971085 hasConceptScore W2809971085C59822182 @default.
- W2809971085 hasConceptScore W2809971085C64903051 @default.
- W2809971085 hasConceptScore W2809971085C71924100 @default.
- W2809971085 hasConceptScore W2809971085C86803240 @default.
- W2809971085 hasLocation W28099710851 @default.
- W2809971085 hasLocation W28099710852 @default.
- W2809971085 hasOpenAccess W2809971085 @default.
- W2809971085 hasPrimaryLocation W28099710851 @default.
- W2809971085 hasRelatedWork W105877818 @default.
- W2809971085 hasRelatedWork W198260912 @default.
- W2809971085 hasRelatedWork W2017409119 @default.
- W2809971085 hasRelatedWork W2033085289 @default.
- W2809971085 hasRelatedWork W2060986047 @default.
- W2809971085 hasRelatedWork W2144891694 @default.
- W2809971085 hasRelatedWork W2151576574 @default.
- W2809971085 hasRelatedWork W2182538774 @default.
- W2809971085 hasRelatedWork W2198556320 @default.
- W2809971085 hasRelatedWork W3039580108 @default.
- W2809971085 isParatext "false" @default.
- W2809971085 isRetracted "false" @default.
- W2809971085 magId "2809971085" @default.
- W2809971085 workType "book-chapter" @default.