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• W2809972014 abstract "Neuroendocrine cells in the pineal gland release melatonin during the night and in teleosts are directly photoreceptive. During development of the pineal complex, a small number of cells migrate leftward away from the pineal anlage to form the parapineal cell cluster, a process which is crucial for asymmetrical development of the bilateral habenular nuclei. Here we show that, throughout zebrafish embryonic development, the brain-specific homeobox (bsx) gene is expressed in all cell types of the pineal complex. We identified Bmp and Noto/Flh as major regulators of bsx expression in the pineal complex. Upon loss of Bsx through the generation of a targeted mutation, embryos fail to form a parapineal organ and develop right-isomerized habenulae. Crucial enzymes in the melatonin biosynthesis pathway are not expressed, suggesting absence of melatonin from the pineal gland of bsx mutants. Several genes involved in rod-like or cone-like phototransduction are also abnormally expressed, indicating that Bsx plays a pivotal role in differentiation of multiple cell types in the zebrafish pineal complex." @default.
• W2809972014 created "2018-07-10" @default.
• W2809972014 creator A5027561182 @default.
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• W2809972014 date "2018-01-01" @default.
• W2809972014 modified "2023-09-25" @default.
• W2809972014 title "Bsx controls pineal complex development" @default.
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• W2809972014 doi "https://doi.org/10.1242/dev.163477" @default.
• W2809972014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29945867" @default.
• W2809972014 hasPublicationYear "2018" @default.
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