FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809986882> ?p ?o ?g. }

• W2809986882 endingPage "440" @default.
• W2809986882 startingPage "430" @default.
• W2809986882 abstract "The Rho GTPase Cdc42 is highly conserved in structure and function. Mechanical or chemical cues in the microenvironment stimulate the localized activation of Cdc42 to rearrange the actin cytoskeleton and establish cell polarity. A role for Cdc42 in cell polarization was first discovered in the budding yeast Saccharomyces cerevisiae, and subsequently shown to also regulate directional motility in animal cells. Accordingly, in cancer Cdc42 promotes migration, invasion, and spread of tumor cells. Therefore, we targeted Cdc42 as a therapeutic strategy to treat metastatic breast cancer and designed the small molecule MBQ-167 as a potent inhibitor against Cdc42 and the homolog Rac. MBQ-167 inhibited cancer cell proliferation and migration in-vitro, and tumor growth and spread in-vivo in a mouse xenograft model of metastatic breast cancer. Since haploid budding yeast express a single Cdc42 gene, and do not express Rac, we used this well characterized model of polarization to define the contribution of Cdc42 inhibition to the effects of MBQ-167 in eukaryotic cells. Growth, budding pattern, and Cdc42 activity was determined in wildtype yeast or cells expressing a conditional knockdown of Cdc42 in response to vehicle or MBQ-167 treatment. As expected, growth and budding polarity were reduced by knocking-down Cdc42, with a parallel effect observed with MBQ-167. Cdc42 activity assays confirmed that MBQ-167 inhibits Cdc42 activation in yeast, and thus, bud polarity. Hence, we have validated MBQ-167 as a Cdc42 inhibitor in another biological context and present a method to screen Cdc42 inhibitors with potential as anti-metastatic cancer drugs." @default.
• W2809986882 created "2018-07-10" @default.
• W2809986882 creator A5020224582 @default.
• W2809986882 creator A5026855277 @default.
• W2809986882 creator A5038748775 @default.
• W2809986882 creator A5049213857 @default.
• W2809986882 creator A5067938366 @default.
• W2809986882 creator A5070057267 @default.
• W2809986882 creator A5090824202 @default.
• W2809986882 date "2018-07-29" @default.
• W2809986882 modified "2023-09-25" @default.
• W2809986882 title "Targeting Cdc42 with the anticancer compound MBQ-167 inhibits cell polarity and growth in the budding yeast S. cerevisiae" @default.
• W2809986882 cites W1534699330 @default.
• W2809986882 cites W1561252486 @default.
• W2809986882 cites W1578932543 @default.
• W2809986882 cites W1971152163 @default.
• W2809986882 cites W1971431550 @default.
• W2809986882 cites W1974220691 @default.
• W2809986882 cites W1987058957 @default.
• W2809986882 cites W1991532100 @default.
• W2809986882 cites W1992842368 @default.
• W2809986882 cites W1994663540 @default.
• W2809986882 cites W2015586742 @default.
• W2809986882 cites W2020410964 @default.
• W2809986882 cites W2034169319 @default.
• W2809986882 cites W2034177419 @default.
• W2809986882 cites W2047712384 @default.
• W2809986882 cites W2060737851 @default.
• W2809986882 cites W2065349113 @default.
• W2809986882 cites W2066767494 @default.
• W2809986882 cites W2067163806 @default.
• W2809986882 cites W2068501150 @default.
• W2809986882 cites W2075362447 @default.
• W2809986882 cites W2080264636 @default.
• W2809986882 cites W2086121244 @default.
• W2809986882 cites W2087973518 @default.
• W2809986882 cites W2089170484 @default.
• W2809986882 cites W2102312968 @default.
• W2809986882 cites W2102748451 @default.
• W2809986882 cites W2107996465 @default.
• W2809986882 cites W2112730617 @default.
• W2809986882 cites W2120425861 @default.
• W2809986882 cites W2121874812 @default.
• W2809986882 cites W2123256370 @default.
• W2809986882 cites W2131964524 @default.
• W2809986882 cites W2137330846 @default.
• W2809986882 cites W2140518858 @default.
• W2809986882 cites W2145859343 @default.
• W2809986882 cites W2158726454 @default.
• W2809986882 cites W2158731289 @default.
• W2809986882 cites W2158761419 @default.
• W2809986882 cites W2162740484 @default.
• W2809986882 cites W2169036201 @default.
• W2809986882 cites W2173348076 @default.
• W2809986882 cites W2179320375 @default.
• W2809986882 cites W2413993846 @default.
• W2809986882 cites W2434643775 @default.
• W2809986882 cites W2465579685 @default.
• W2809986882 cites W2520842278 @default.
• W2809986882 cites W2582835905 @default.
• W2809986882 cites W2601714044 @default.
• W2809986882 cites W2608191634 @default.
• W2809986882 cites W2621089962 @default.
• W2809986882 cites W2766955181 @default.
• W2809986882 cites W3024468432 @default.
• W2809986882 cites W4256348363 @default.
• W2809986882 cites W4285719527 @default.
• W2809986882 cites W4289877050 @default.
• W2809986882 cites W2763226353 @default.
• W2809986882 doi "https://doi.org/10.1080/21541248.2018.1495008" @default.
• W2809986882 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7549613" @default.
• W2809986882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29969362" @default.
• W2809986882 hasPublicationYear "2018" @default.
• W2809986882 type Work @default.
• W2809986882 sameAs 2809986882 @default.
• W2809986882 citedByCount "7" @default.
• W2809986882 countsByYear W28099868822019 @default.
• W2809986882 countsByYear W28099868822020 @default.
• W2809986882 countsByYear W28099868822021 @default.
• W2809986882 countsByYear W28099868822022 @default.
• W2809986882 countsByYear W28099868822023 @default.
• W2809986882 crossrefType "journal-article" @default.
• W2809986882 hasAuthorship W2809986882A5020224582 @default.
• W2809986882 hasAuthorship W2809986882A5026855277 @default.
• W2809986882 hasAuthorship W2809986882A5038748775 @default.
• W2809986882 hasAuthorship W2809986882A5049213857 @default.
• W2809986882 hasAuthorship W2809986882A5067938366 @default.
• W2809986882 hasAuthorship W2809986882A5070057267 @default.
• W2809986882 hasAuthorship W2809986882A5090824202 @default.
• W2809986882 hasBestOaLocation W28099868821 @default.
• W2809986882 hasConcept C104317684 @default.
• W2809986882 hasConcept C121608353 @default.
• W2809986882 hasConcept C134935766 @default.
• W2809986882 hasConcept C142669718 @default.
• W2809986882 hasConcept C1491633281 @default.
• W2809986882 hasConcept C207332259 @default.
• W2809986882 hasConcept C2777576037 @default.
• W2809986882 hasConcept C2778502085 @default.

• next