Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810040379> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2810040379 endingPage "97" @default.
- W2810040379 startingPage "89" @default.
- W2810040379 abstract "In the present work two key regulator proteins, monomeric MipZ of Caulobacter vibrioides (similar to Pseudomonas aeruginosa) and Pyruvate kinase of Staphylococcus aureus were docked with curcumin, the wonder molecule from the spice turmeric and structures of its twelve analogues were designed, synthesized and tested in-vitro for antibacterial activity. Based on the test results a comparative account of the probable mechanism has been given Two major alternative targets are possible for antibacterial activity of drug molecules. These may be bacterial cell wall lipids or the proteins responsible for smooth functioning of bacterial cells. In the former case, due to significant difference in the structural components of the cell walls of Gram positive and Gram negative bacteria, it is improbable that same ligand will affect both equally. Majority of commercial drugs are anti-Gram negative bacteria while in the present work we have found most effective drugs against Gram positive bacteria. Based on the test results a comparative account of the probable mechanism has been given. Evidently along with the cell wall damaging mechanism other parallel mechanisms are also operative." @default.
- W2810040379 created "2018-07-10" @default.
- W2810040379 creator A5050966421 @default.
- W2810040379 creator A5052908383 @default.
- W2810040379 creator A5066695289 @default.
- W2810040379 creator A5086543174 @default.
- W2810040379 creator A5088321433 @default.
- W2810040379 date "2018-10-01" @default.
- W2810040379 modified "2023-10-01" @default.
- W2810040379 title "In-silico designing, chemical synthesis, characterization and in-vitro assessment of antibacterial properties of some analogues of curcumin" @default.
- W2810040379 cites W12653918 @default.
- W2810040379 cites W1568824452 @default.
- W2810040379 cites W1895524095 @default.
- W2810040379 cites W1993915524 @default.
- W2810040379 cites W2017003000 @default.
- W2810040379 cites W2029816748 @default.
- W2810040379 cites W2042182152 @default.
- W2810040379 cites W2057470390 @default.
- W2810040379 cites W2065935900 @default.
- W2810040379 cites W2077305072 @default.
- W2810040379 cites W2079953901 @default.
- W2810040379 cites W2105668062 @default.
- W2810040379 cites W2109126671 @default.
- W2810040379 cites W2164380664 @default.
- W2810040379 cites W2516264461 @default.
- W2810040379 cites W2778866704 @default.
- W2810040379 cites W2951765595 @default.
- W2810040379 doi "https://doi.org/10.1016/j.micpath.2018.06.030" @default.
- W2810040379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29959040" @default.
- W2810040379 hasPublicationYear "2018" @default.
- W2810040379 type Work @default.
- W2810040379 sameAs 2810040379 @default.
- W2810040379 citedByCount "5" @default.
- W2810040379 countsByYear W28100403792019 @default.
- W2810040379 countsByYear W28100403792021 @default.
- W2810040379 countsByYear W28100403792022 @default.
- W2810040379 crossrefType "journal-article" @default.
- W2810040379 hasAuthorship W2810040379A5050966421 @default.
- W2810040379 hasAuthorship W2810040379A5052908383 @default.
- W2810040379 hasAuthorship W2810040379A5066695289 @default.
- W2810040379 hasAuthorship W2810040379A5086543174 @default.
- W2810040379 hasAuthorship W2810040379A5088321433 @default.
- W2810040379 hasConcept C104317684 @default.
- W2810040379 hasConcept C185592680 @default.
- W2810040379 hasConcept C19655278 @default.
- W2810040379 hasConcept C202751555 @default.
- W2810040379 hasConcept C2775905019 @default.
- W2810040379 hasConcept C2776051709 @default.
- W2810040379 hasConcept C2777637488 @default.
- W2810040379 hasConcept C2778250585 @default.
- W2810040379 hasConcept C2779489039 @default.
- W2810040379 hasConcept C2779518903 @default.
- W2810040379 hasConcept C2780104969 @default.
- W2810040379 hasConcept C4937899 @default.
- W2810040379 hasConcept C523546767 @default.
- W2810040379 hasConcept C54355233 @default.
- W2810040379 hasConcept C547475151 @default.
- W2810040379 hasConcept C55493867 @default.
- W2810040379 hasConcept C86803240 @default.
- W2810040379 hasConcept C89423630 @default.
- W2810040379 hasConceptScore W2810040379C104317684 @default.
- W2810040379 hasConceptScore W2810040379C185592680 @default.
- W2810040379 hasConceptScore W2810040379C19655278 @default.
- W2810040379 hasConceptScore W2810040379C202751555 @default.
- W2810040379 hasConceptScore W2810040379C2775905019 @default.
- W2810040379 hasConceptScore W2810040379C2776051709 @default.
- W2810040379 hasConceptScore W2810040379C2777637488 @default.
- W2810040379 hasConceptScore W2810040379C2778250585 @default.
- W2810040379 hasConceptScore W2810040379C2779489039 @default.
- W2810040379 hasConceptScore W2810040379C2779518903 @default.
- W2810040379 hasConceptScore W2810040379C2780104969 @default.
- W2810040379 hasConceptScore W2810040379C4937899 @default.
- W2810040379 hasConceptScore W2810040379C523546767 @default.
- W2810040379 hasConceptScore W2810040379C54355233 @default.
- W2810040379 hasConceptScore W2810040379C547475151 @default.
- W2810040379 hasConceptScore W2810040379C55493867 @default.
- W2810040379 hasConceptScore W2810040379C86803240 @default.
- W2810040379 hasConceptScore W2810040379C89423630 @default.
- W2810040379 hasLocation W28100403791 @default.
- W2810040379 hasLocation W28100403792 @default.
- W2810040379 hasOpenAccess W2810040379 @default.
- W2810040379 hasPrimaryLocation W28100403791 @default.
- W2810040379 hasRelatedWork W2101316665 @default.
- W2810040379 hasRelatedWork W2138075140 @default.
- W2810040379 hasRelatedWork W2163151727 @default.
- W2810040379 hasRelatedWork W2326830576 @default.
- W2810040379 hasRelatedWork W2399363405 @default.
- W2810040379 hasRelatedWork W2938833484 @default.
- W2810040379 hasRelatedWork W3007924600 @default.
- W2810040379 hasRelatedWork W3086436846 @default.
- W2810040379 hasRelatedWork W3211025746 @default.
- W2810040379 hasRelatedWork W4291511792 @default.
- W2810040379 hasVolume "123" @default.
- W2810040379 isParatext "false" @default.
- W2810040379 isRetracted "false" @default.
- W2810040379 magId "2810040379" @default.
- W2810040379 workType "article" @default.