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- W2810043386 abstract "Abstract Decades of research on the four receptor tyrosine kinases (RTKs) that comprise the human epidermal growth factor receptor (HER) family have established these proteins as key oncogenes in many cancer types. The strong evidence supporting pro-tumorigenic roles of HER3, HER4, and especially epidermal growth factor receptor (EGFR) and HER2 in cancer has led to the generation and use of HER family-targeted agents that can inhibit one or more of these RTKs. Although these inhibitors are used as a single agent in some contexts, they are often used in combination with chemotherapeutic agents and have been shown to enhance the response to chemotherapy in many cancer types. In this chapter, we outline the basic biology of the HER family receptors before examining each of the four receptors, focusing on mutations and other alterations that occur in cancer and on preclinical and clinical studies in which HER family-targeted agents were used to delay and/or overcome chemoresistance. Throughout, we address open questions in the field and discuss current and future areas of research." @default.
- W2810043386 created "2018-07-10" @default.
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- W2810043386 date "2019-01-01" @default.
- W2810043386 modified "2023-09-26" @default.
- W2810043386 title "Targeting Members of the Epidermal Growth Factor Receptor Family to Improve Response to Chemotherapy" @default.
- W2810043386 doi "https://doi.org/10.1016/b978-0-12-813753-6.00001-9" @default.
- W2810043386 hasPublicationYear "2019" @default.
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