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- W2810076504 abstract "Significance Human DNA is 2 m long and is folded into a 10-μm-sized cellular nucleus. Experiments have revealed two major features of genome organization: Segregation of alternating active and inactive regions into compartments, and formation of compacted local domains. These were hypothesized to be formed by different mechanisms: Compartments can be formed by microphase separation and domains by active, motor-driven, loop extrusion. Here, we integrate these mechanisms into a polymer model and show that their interplay coherently explains diverse experimental data for wild-type and mutant cells. Our results provide a framework for the interpretation of chromosome organization in cellular phenotypes and highlight that chromatin is a complex, active matter shaped by an interplay of phase segregation and loop extrusion." @default.
- W2810076504 created "2018-07-10" @default.
- W2810076504 creator A5005859234 @default.
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- W2810076504 date "2018-07-02" @default.
- W2810076504 modified "2023-10-17" @default.
- W2810076504 title "Chromatin organization by an interplay of loop extrusion and compartmental segregation" @default.
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- W2810076504 doi "https://doi.org/10.1073/pnas.1717730115" @default.
- W2810076504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6055145" @default.
- W2810076504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29967174" @default.
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