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• W281008054 abstract "The aim of the present study was to determine the effect of selenium and vitamin E on gastric mucosal damage and acid secretion induced water immersion restraint stress (WRS) in Wistar rats. (n= 70) Wistar rats of both sexes, weighing 200-220 g were divided in to five groups of seven rats each, viz: (i) passive control (non-stress rats), (ii) active control (WRS + distilled water), (iii) WRS + vitamin E, (iv) WRS + vitamin E + selenium, and (v) WRS + selenium. The WRS procedure lasted for 3.5 hours. Gastric tissues were isolated and investigated macroscopically and histologically to determine mucosal damage. Gastric secretion was collected after additional 3 hours of pyloric ligation. Blood samples were collected through cardiac puncture for the investigation of plasma concentration of malondialdehyde (MDA). The result demonstrated that acute WRS significantly (P < 0.001) increase gastric ulcer and gastric secretion parameters as well as MDA concentration. Pre-treatment with selenium or vitamin E significantly lowered the gastric parameters and MDA concentration especially in rats co-administered with selenium and vitamin E. It was concluded that acute WRS exposure causes significant alteration in the structure of the gastric tissue and increased plasma MDA. Pre-treatment with selenium and vitamin E ameliorated the adverse effects of WRS, and co-administration of selenium and vitamin E exerted synergistic effects in the restoration of WRS-induced changes." @default.
• W281008054 created "2016-06-24" @default.
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• W281008054 date "2015-03-23" @default.
• W281008054 modified "2023-09-26" @default.
• W281008054 title "Role of Selenium and Vitamin E on Gastric Mucosal Damage Induced By Water-Immersion Restraint Stress in Wistar Rats" @default.
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• W281008054 doi "https://doi.org/10.6084/m9.figshare.1348682.v1" @default.
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