Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810090803> ?p ?o ?g. }
- W2810090803 abstract "This study aimed to investigate effects of intravenous infusion with sodium butyrate (SB) on colonic microbiota, intestinal mucosal immune and intestinal development in normal growing pigs. Twelve crossbred barrows (Duroc × Landrace × Large White) fitted with a medical polyethylene cannula via internal jugular vein were daily infused with 10 ml SB (200 mmol/l) or the same volume of physiological saline for 7 days. Results showed that SB infusion had no effects on the short-chain fatty acids concentrations and the number of total bacteria, but significantly increased the microbial richness estimators (ACE and Chao1), and the abundance of genera related to Clostridiales order in the colonic digesta (P < 0.05). SB infusion significantly up-regulated the mRNA expression of monocarboxylate transporter 1 (MCT1) in the colon, while no change was found in the ileum. Only the relative mRNA of pro-inflammatory cytokine IL-6 gene was decreased significantly in the ileum by SB infusion. On the contrary, in the colon, SB infusion significantly decreased the gene expression of histone deacetylase 1 (HDAC1) and pro-inflammatory cytokines IL-6, IL-18, IL-12p40, and TNF-α (P < 0.05), but significantly increased the secretory immunoglobulin A (sIgA) concentration, the gene expression of anti-inflammatory cytokine IL-10, and the expression of intestinal development-related gene zonula occludens-1 (ZO-1), occludin, and epidermal growth factor (EGF) (P < 0.05). The results suggest that systemic SB can modify colonic microbial composition, regulate the inflammatory cytokine- and intestinal development-related gene expression in pigs under the normal physiological condition. This study may provide an alternative strategy for improving the intestinal health of normal piglets." @default.
- W2810090803 created "2018-07-10" @default.
- W2810090803 creator A5045572371 @default.
- W2810090803 creator A5055831817 @default.
- W2810090803 creator A5056437521 @default.
- W2810090803 creator A5074817013 @default.
- W2810090803 date "2018-07-20" @default.
- W2810090803 modified "2023-10-12" @default.
- W2810090803 title "Effects of Intravenous Infusion With Sodium Butyrate on Colonic Microbiota, Intestinal Development- and Mucosal Immune-Related Gene Expression in Normal Growing Pigs" @default.
- W2810090803 cites W1572941268 @default.
- W2810090803 cites W1607450206 @default.
- W2810090803 cites W1880025598 @default.
- W2810090803 cites W1888445862 @default.
- W2810090803 cites W1932348039 @default.
- W2810090803 cites W1963507142 @default.
- W2810090803 cites W1974972571 @default.
- W2810090803 cites W1982696037 @default.
- W2810090803 cites W1989565555 @default.
- W2810090803 cites W2000413463 @default.
- W2810090803 cites W2000987159 @default.
- W2810090803 cites W2001510875 @default.
- W2810090803 cites W2002703043 @default.
- W2810090803 cites W2008194879 @default.
- W2810090803 cites W2013395086 @default.
- W2810090803 cites W2014903605 @default.
- W2810090803 cites W2018861313 @default.
- W2810090803 cites W2028424107 @default.
- W2810090803 cites W2029180586 @default.
- W2810090803 cites W2030042615 @default.
- W2810090803 cites W2030243507 @default.
- W2810090803 cites W2031174985 @default.
- W2810090803 cites W2033494912 @default.
- W2810090803 cites W2034082915 @default.
- W2810090803 cites W2037622180 @default.
- W2810090803 cites W2044219890 @default.
- W2810090803 cites W2045186127 @default.
- W2810090803 cites W2048616064 @default.
- W2810090803 cites W2053621679 @default.
- W2810090803 cites W2058497200 @default.
- W2810090803 cites W2060669952 @default.
- W2810090803 cites W2063053656 @default.
- W2810090803 cites W2073934305 @default.
- W2810090803 cites W2074122765 @default.
- W2810090803 cites W2077175809 @default.
- W2810090803 cites W2082092506 @default.
- W2810090803 cites W2087484885 @default.
- W2810090803 cites W2089212356 @default.
- W2810090803 cites W2090235351 @default.
- W2810090803 cites W2105335085 @default.
- W2810090803 cites W2105423509 @default.
- W2810090803 cites W2108599358 @default.
- W2810090803 cites W2108718991 @default.
- W2810090803 cites W2112066013 @default.
- W2810090803 cites W2112738213 @default.
- W2810090803 cites W2119472607 @default.
- W2810090803 cites W2120607254 @default.
- W2810090803 cites W2121265058 @default.
- W2810090803 cites W2125578816 @default.
- W2810090803 cites W2129837723 @default.
- W2810090803 cites W2138997261 @default.
- W2810090803 cites W2141125135 @default.
- W2810090803 cites W2142537875 @default.
- W2810090803 cites W2147618390 @default.
- W2810090803 cites W2156843995 @default.
- W2810090803 cites W2166709849 @default.
- W2810090803 cites W2171100102 @default.
- W2810090803 cites W2172526487 @default.
- W2810090803 cites W2220763144 @default.
- W2810090803 cites W2286166764 @default.
- W2810090803 cites W2330645959 @default.
- W2810090803 cites W2404398938 @default.
- W2810090803 cites W2514743616 @default.
- W2810090803 cites W2559474155 @default.
- W2810090803 cites W2625718424 @default.
- W2810090803 cites W278701132 @default.
- W2810090803 cites W281568493 @default.
- W2810090803 cites W40840948 @default.
- W2810090803 doi "https://doi.org/10.3389/fmicb.2018.01652" @default.
- W2810090803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6062594" @default.
- W2810090803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30079060" @default.
- W2810090803 hasPublicationYear "2018" @default.
- W2810090803 type Work @default.
- W2810090803 sameAs 2810090803 @default.
- W2810090803 citedByCount "17" @default.
- W2810090803 countsByYear W28100908032019 @default.
- W2810090803 countsByYear W28100908032020 @default.
- W2810090803 countsByYear W28100908032021 @default.
- W2810090803 countsByYear W28100908032022 @default.
- W2810090803 countsByYear W28100908032023 @default.
- W2810090803 crossrefType "journal-article" @default.
- W2810090803 hasAuthorship W2810090803A5045572371 @default.
- W2810090803 hasAuthorship W2810090803A5055831817 @default.
- W2810090803 hasAuthorship W2810090803A5056437521 @default.
- W2810090803 hasAuthorship W2810090803A5074817013 @default.
- W2810090803 hasBestOaLocation W28100908031 @default.
- W2810090803 hasConcept C100544194 @default.
- W2810090803 hasConcept C104317684 @default.
- W2810090803 hasConcept C126322002 @default.
- W2810090803 hasConcept C134018914 @default.
- W2810090803 hasConcept C150194340 @default.