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- W2810108980 abstract "This review addresses the function of the layers of the cerebral cortex. We develop the perspective that cortical layering needs to be understood in terms of its functional anatomy, i.e. the terminations of synaptic inputs on distinct cellular compartments and their effect on cortical activity. The cortex is a hierarchical structure in which feed forward and feedback pathways have a layer-specific termination pattern. We take the view that the influence of synaptic inputs arriving at different cortical layers can only be understood in terms of their complex interaction with cellular biophysics and the subsequent computation that occurs at the cellular level. We use high-resolution fMRI, which can resolve activity across layers, as a case study for implementing this approach by describing how cognitive events arising from the laminar distribution of inputs can be interpreted by taking into account the properties of neurons that span different layers. This perspective is based on recent advances in measuring subcellular activity in distinct feed-forward and feedback axons and in dendrites as they span across layers." @default.
- W2810108980 created "2018-07-10" @default.
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- W2810108980 date "2018-07-17" @default.
- W2810108980 modified "2023-10-01" @default.
- W2810108980 title "A Perspective on Cortical Layering and Layer-Spanning Neuronal Elements" @default.
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- W2810108980 doi "https://doi.org/10.3389/fnana.2018.00056" @default.
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