Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810148638> ?p ?o ?g. }
- W2810148638 endingPage "10" @default.
- W2810148638 startingPage "1" @default.
- W2810148638 abstract "Even after recovery from acute kidney injury, glomeruli remain vulnerable to further injury by way of interstitial fibrosis. This study is aimed at elucidating the effects of post ischemia-reperfusion (I/R) treatment with trimetazidine on the progression to renal fibrosis as well as short- and intermediate-term aspects. Trimetazidine 3 mg/kg or 0.9% saline was given intraperitoneally once upon reperfusion or daily thereafter for 5 d or 8 w. Renal histologic changes and related signaling proteins were assessed. After 24 h, post I/R treatment with trimetazidine significantly reduced serum blood urea nitrogen and creatinine levels and tubular injury accompanied with upregulation of hypoxia-inducible factor- (HIF-) 1 α , vascular endothelial growth factor (VEGF), and Bcl-2 expression. After 5 d, post I/R treatment with trimetazidine reduced renal tubular cell necrosis and apoptosis with upregulation of HIF-1 α -VEGF and tissue inhibitors of metalloproteinase activities, attenuation of matrix metalloproteinase activities, and alteration of the ratio of Bax to Bcl-2 levels. After 8 w, however, post I/R treatment with trimetazidine did not modify the progression of renal fibrosis. In conclusion, post I/R treatment with trimetazidine allows ischemic kidneys to regain renal function and structure more rapidly compared to nontreated kidneys, but not enough to resolute renal fibrosis in long-term aspect." @default.
- W2810148638 created "2018-07-10" @default.
- W2810148638 creator A5003252781 @default.
- W2810148638 creator A5006824750 @default.
- W2810148638 creator A5011857220 @default.
- W2810148638 creator A5038750502 @default.
- W2810148638 creator A5050752210 @default.
- W2810148638 creator A5078835974 @default.
- W2810148638 date "2018-07-02" @default.
- W2810148638 modified "2023-09-25" @default.
- W2810148638 title "Effects of Post Ischemia-Reperfusion Treatment with Trimetazidine on Renal Injury in Rats: Insights on Delayed Renal Fibrosis Progression" @default.
- W2810148638 cites W1491333270 @default.
- W2810148638 cites W1933832368 @default.
- W2810148638 cites W1963848634 @default.
- W2810148638 cites W1969080012 @default.
- W2810148638 cites W1982049843 @default.
- W2810148638 cites W1991385182 @default.
- W2810148638 cites W1993847258 @default.
- W2810148638 cites W2000512590 @default.
- W2810148638 cites W2007260104 @default.
- W2810148638 cites W2015291188 @default.
- W2810148638 cites W2016582054 @default.
- W2810148638 cites W2019032615 @default.
- W2810148638 cites W2035039019 @default.
- W2810148638 cites W2035772555 @default.
- W2810148638 cites W2041338170 @default.
- W2810148638 cites W2043056756 @default.
- W2810148638 cites W2043833835 @default.
- W2810148638 cites W2064039718 @default.
- W2810148638 cites W2070238157 @default.
- W2810148638 cites W2079244425 @default.
- W2810148638 cites W2082137823 @default.
- W2810148638 cites W2090592050 @default.
- W2810148638 cites W2096774519 @default.
- W2810148638 cites W2107507822 @default.
- W2810148638 cites W2107628049 @default.
- W2810148638 cites W2113429819 @default.
- W2810148638 cites W2117581987 @default.
- W2810148638 cites W2123860179 @default.
- W2810148638 cites W2131419242 @default.
- W2810148638 cites W2135398118 @default.
- W2810148638 cites W2140337836 @default.
- W2810148638 cites W2152223470 @default.
- W2810148638 cites W2154921775 @default.
- W2810148638 cites W2155186492 @default.
- W2810148638 cites W2158794894 @default.
- W2810148638 cites W2159033534 @default.
- W2810148638 cites W2159337133 @default.
- W2810148638 cites W2163615971 @default.
- W2810148638 cites W2164965999 @default.
- W2810148638 cites W2169257100 @default.
- W2810148638 cites W2170023789 @default.
- W2810148638 cites W2170263816 @default.
- W2810148638 cites W2170597525 @default.
- W2810148638 cites W2216095137 @default.
- W2810148638 cites W2284130256 @default.
- W2810148638 cites W2339985484 @default.
- W2810148638 cites W2410011894 @default.
- W2810148638 cites W2613483874 @default.
- W2810148638 cites W2619233510 @default.
- W2810148638 cites W4254671684 @default.
- W2810148638 doi "https://doi.org/10.1155/2018/1072805" @default.
- W2810148638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6051050" @default.
- W2810148638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30057668" @default.
- W2810148638 hasPublicationYear "2018" @default.
- W2810148638 type Work @default.
- W2810148638 sameAs 2810148638 @default.
- W2810148638 citedByCount "8" @default.
- W2810148638 countsByYear W28101486382020 @default.
- W2810148638 countsByYear W28101486382021 @default.
- W2810148638 countsByYear W28101486382022 @default.
- W2810148638 countsByYear W28101486382023 @default.
- W2810148638 crossrefType "journal-article" @default.
- W2810148638 hasAuthorship W2810148638A5003252781 @default.
- W2810148638 hasAuthorship W2810148638A5006824750 @default.
- W2810148638 hasAuthorship W2810148638A5011857220 @default.
- W2810148638 hasAuthorship W2810148638A5038750502 @default.
- W2810148638 hasAuthorship W2810148638A5050752210 @default.
- W2810148638 hasAuthorship W2810148638A5078835974 @default.
- W2810148638 hasBestOaLocation W28101486381 @default.
- W2810148638 hasConcept C104317684 @default.
- W2810148638 hasConcept C126322002 @default.
- W2810148638 hasConcept C126894567 @default.
- W2810148638 hasConcept C127561419 @default.
- W2810148638 hasConcept C134018914 @default.
- W2810148638 hasConcept C159641895 @default.
- W2810148638 hasConcept C185592680 @default.
- W2810148638 hasConcept C2777927741 @default.
- W2810148638 hasConcept C2778176769 @default.
- W2810148638 hasConcept C2780091579 @default.
- W2810148638 hasConcept C2780114680 @default.
- W2810148638 hasConcept C2780306776 @default.
- W2810148638 hasConcept C2780559512 @default.
- W2810148638 hasConcept C2780721119 @default.
- W2810148638 hasConcept C541997718 @default.
- W2810148638 hasConcept C55493867 @default.
- W2810148638 hasConcept C71924100 @default.
- W2810148638 hasConcept C98274493 @default.