FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810182866> ?p ?o ?g. }

• W2810182866 endingPage "254" @default.
• W2810182866 startingPage "235" @default.
• W2810182866 abstract "Multiple classes of medications have been studied for the treatment of Raynaud’s phenomenon (RP) with or without digital ischemia. The goal of this review is to discuss the outcomes of recent studies and to report on our approach to the management of RP in light of the available evidence. Comparing treatments for RP remains a challenge as efficacy endpoint vary widely among trials. While calcium channel blockers (CCB) are used first line in the pharmacologic management of RP, phosphodiesterase 5 inhibitors (PDE5i) have also been shown to be beneficial in reducing symptoms. In the setting of digital ischemia, administration of intravenous prostanoids is the standard of care. Bosentan an endothelin receptor antagonist (ERA), has shown benefit in the prevention of future digital ulcers in patients with scleroderma. Botulinum toxin (Btx) therapy was ineffective in a clinical trial involving scleroderma patients; more controlled studies are needed in other subsets of patients. Digital sympathectomy may be beneficial in cases of critical digital ischemia, though recurrence of symptoms is common. Comparative effectiveness studies are needed to determine which therapeutic interventions are most beneficial in patients with RP. Based on the available evidence, we start with a CCB and add a PDE5i if symptoms are not controlled, or an intravenous prostacyclin in the setting of severe critical digital ischemia. We may additionally add an ERA in cases of recurrent digital ulcers. A surgical sympathectomy may be used in refractory cases of digital ischemia. A digital block may also be a less invasive, but temporary, intervention allowing for titration of medical therapy." @default.
• W2810182866 created "2018-07-10" @default.
• W2810182866 creator A5068528030 @default.
• W2810182866 creator A5080282433 @default.
• W2810182866 date "2018-07-04" @default.
• W2810182866 modified "2023-10-17" @default.
• W2810182866 title "Pharmacotherapy Options in the Management of Raynaud’s Phenomenon" @default.
• W2810182866 cites W1009628474 @default.
• W2810182866 cites W1547026755 @default.
• W2810182866 cites W184935815 @default.
• W2810182866 cites W1972905363 @default.
• W2810182866 cites W1980026911 @default.
• W2810182866 cites W1981031097 @default.
• W2810182866 cites W1985895863 @default.
• W2810182866 cites W1997973846 @default.
• W2810182866 cites W1999701858 @default.
• W2810182866 cites W2034204078 @default.
• W2810182866 cites W2036120327 @default.
• W2810182866 cites W2037001242 @default.
• W2810182866 cites W2043070178 @default.
• W2810182866 cites W2048194246 @default.
• W2810182866 cites W2054504088 @default.
• W2810182866 cites W2055651139 @default.
• W2810182866 cites W2064087261 @default.
• W2810182866 cites W2073501412 @default.
• W2810182866 cites W2075038816 @default.
• W2810182866 cites W2077019257 @default.
• W2810182866 cites W2079587435 @default.
• W2810182866 cites W2089752909 @default.
• W2810182866 cites W2090117500 @default.
• W2810182866 cites W2096107056 @default.
• W2810182866 cites W2110511303 @default.
• W2810182866 cites W2113918265 @default.
• W2810182866 cites W2118846800 @default.
• W2810182866 cites W2124159683 @default.
• W2810182866 cites W2124352615 @default.
• W2810182866 cites W2128484539 @default.
• W2810182866 cites W2130052733 @default.
• W2810182866 cites W2134455827 @default.
• W2810182866 cites W2138532409 @default.
• W2810182866 cites W2141863343 @default.
• W2810182866 cites W2149568156 @default.
• W2810182866 cites W2153225921 @default.
• W2810182866 cites W2156654932 @default.
• W2810182866 cites W2160183761 @default.
• W2810182866 cites W2163154920 @default.
• W2810182866 cites W2164474017 @default.
• W2810182866 cites W2166493507 @default.
• W2810182866 cites W2278696749 @default.
• W2810182866 cites W2311508410 @default.
• W2810182866 cites W2380725409 @default.
• W2810182866 cites W2416548206 @default.
• W2810182866 cites W2425216987 @default.
• W2810182866 cites W2494784546 @default.
• W2810182866 cites W2496760040 @default.
• W2810182866 cites W2549071917 @default.
• W2810182866 cites W2560938650 @default.
• W2810182866 cites W2579427976 @default.
• W2810182866 cites W2607246919 @default.
• W2810182866 cites W2774060756 @default.
• W2810182866 cites W2774833117 @default.
• W2810182866 cites W2782385151 @default.
• W2810182866 cites W2783335955 @default.
• W2810182866 cites W2787845637 @default.
• W2810182866 cites W2791105032 @default.
• W2810182866 cites W2970252089 @default.
• W2810182866 cites W30101620 @default.
• W2810182866 cites W4246723420 @default.
• W2810182866 cites W8514648 @default.
• W2810182866 cites W2341270871 @default.
• W2810182866 doi "https://doi.org/10.1007/s40674-018-0102-6" @default.
• W2810182866 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6752040" @default.
• W2810182866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31538045" @default.
• W2810182866 hasPublicationYear "2018" @default.
• W2810182866 type Work @default.
• W2810182866 sameAs 2810182866 @default.
• W2810182866 citedByCount "11" @default.
• W2810182866 countsByYear W28101828662019 @default.
• W2810182866 countsByYear W28101828662020 @default.
• W2810182866 countsByYear W28101828662021 @default.
• W2810182866 countsByYear W28101828662022 @default.
• W2810182866 countsByYear W28101828662023 @default.
• W2810182866 crossrefType "journal-article" @default.
• W2810182866 hasAuthorship W2810182866A5068528030 @default.
• W2810182866 hasAuthorship W2810182866A5080282433 @default.
• W2810182866 hasBestOaLocation W28101828662 @default.
• W2810182866 hasConcept C126322002 @default.
• W2810182866 hasConcept C141071460 @default.
• W2810182866 hasConcept C142724271 @default.
• W2810182866 hasConcept C144980905 @default.
• W2810182866 hasConcept C164705383 @default.
• W2810182866 hasConcept C170493617 @default.
• W2810182866 hasConcept C177713679 @default.
• W2810182866 hasConcept C204787440 @default.
• W2810182866 hasConcept C27081682 @default.
• W2810182866 hasConcept C2781103887 @default.
• W2810182866 hasConcept C2781109936 @default.
• W2810182866 hasConcept C2781128415 @default.

• next