Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810204953> ?p ?o ?g. }
- W2810204953 endingPage "2630" @default.
- W2810204953 startingPage "2621" @default.
- W2810204953 abstract "Prolonged bed rest and microgravity in space cause intervertebral disc (IVD) degeneration. However, the underlying molecular mechanisms are not completely understood. Transient receptor potential canonical (TRPC) channels are implicated in mechanosensing of several tissues, but are poorly explored in IVDs.Primary human IVD cells from surgical biopsies composed of both annulus fibrosus and nucleus pulposus (passage 1-2) were exposed to simulated microgravity and to the TRPC channel inhibitor SKF-96365 (SKF) for up to 5 days. Proliferative capacity, cell cycle distribution, senescence and TRPC channel expression were analyzed.Both simulated microgravity and TRPC channel antagonism reduced the proliferative capacity of IVD cells and induced senescence. While significant changes in cell cycle distributions (reduction in G1 and accumulation in G2/M) were observed upon SKF treatment, the effect was small upon 3 days of simulated microgravity. Finally, downregulation of TRPC6 was shown under simulated microgravity.Simulated microgravity and TRPC channel inhibition both led to reduced proliferation and increased senescence. Furthermore, simulated microgravity reduced TRPC6 expression. IVD cell senescence and mechanotransduction may hence potentially be regulated by TRPC6 expression. This study thus reveals promising targets for future studies. These slides can be retrieved under Electronic Supplementary Material." @default.
- W2810204953 created "2018-07-10" @default.
- W2810204953 creator A5001293774 @default.
- W2810204953 creator A5003737733 @default.
- W2810204953 creator A5004167699 @default.
- W2810204953 creator A5004843806 @default.
- W2810204953 creator A5007540485 @default.
- W2810204953 creator A5008913656 @default.
- W2810204953 creator A5010468676 @default.
- W2810204953 creator A5022517973 @default.
- W2810204953 creator A5032916124 @default.
- W2810204953 creator A5058292733 @default.
- W2810204953 creator A5068368469 @default.
- W2810204953 creator A5071881588 @default.
- W2810204953 date "2018-07-02" @default.
- W2810204953 modified "2023-09-25" @default.
- W2810204953 title "TRPC6 in simulated microgravity of intervertebral disc cells" @default.
- W2810204953 cites W1560291128 @default.
- W2810204953 cites W1597951212 @default.
- W2810204953 cites W1705756688 @default.
- W2810204953 cites W1894046416 @default.
- W2810204953 cites W1902159756 @default.
- W2810204953 cites W194028283 @default.
- W2810204953 cites W1945607022 @default.
- W2810204953 cites W1970641636 @default.
- W2810204953 cites W1973853894 @default.
- W2810204953 cites W1979261758 @default.
- W2810204953 cites W1982370874 @default.
- W2810204953 cites W1990808391 @default.
- W2810204953 cites W2001857305 @default.
- W2810204953 cites W2010345740 @default.
- W2810204953 cites W2024626716 @default.
- W2810204953 cites W2036145275 @default.
- W2810204953 cites W2036806716 @default.
- W2810204953 cites W2041628356 @default.
- W2810204953 cites W2043267612 @default.
- W2810204953 cites W2043984487 @default.
- W2810204953 cites W2049911818 @default.
- W2810204953 cites W2050264923 @default.
- W2810204953 cites W2050480410 @default.
- W2810204953 cites W2060861339 @default.
- W2810204953 cites W2065019610 @default.
- W2810204953 cites W2065246790 @default.
- W2810204953 cites W2088398435 @default.
- W2810204953 cites W2090164016 @default.
- W2810204953 cites W2091025894 @default.
- W2810204953 cites W2092899908 @default.
- W2810204953 cites W2096158665 @default.
- W2810204953 cites W2105744792 @default.
- W2810204953 cites W2106723837 @default.
- W2810204953 cites W2121514550 @default.
- W2810204953 cites W2123821833 @default.
- W2810204953 cites W2131701458 @default.
- W2810204953 cites W2139585666 @default.
- W2810204953 cites W2140277420 @default.
- W2810204953 cites W2152983876 @default.
- W2810204953 cites W2156945795 @default.
- W2810204953 cites W2159272367 @default.
- W2810204953 cites W2167201719 @default.
- W2810204953 cites W2281598305 @default.
- W2810204953 cites W2301131921 @default.
- W2810204953 cites W2318585930 @default.
- W2810204953 cites W2401111187 @default.
- W2810204953 cites W2410068705 @default.
- W2810204953 cites W2475920098 @default.
- W2810204953 cites W2504171339 @default.
- W2810204953 cites W2580597002 @default.
- W2810204953 cites W2589307034 @default.
- W2810204953 cites W2606023772 @default.
- W2810204953 cites W2763052316 @default.
- W2810204953 cites W2768522485 @default.
- W2810204953 cites W2772841075 @default.
- W2810204953 cites W2792833761 @default.
- W2810204953 cites W4250020723 @default.
- W2810204953 doi "https://doi.org/10.1007/s00586-018-5688-8" @default.
- W2810204953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29968164" @default.
- W2810204953 hasPublicationYear "2018" @default.
- W2810204953 type Work @default.
- W2810204953 sameAs 2810204953 @default.
- W2810204953 citedByCount "12" @default.
- W2810204953 countsByYear W28102049532019 @default.
- W2810204953 countsByYear W28102049532020 @default.
- W2810204953 countsByYear W28102049532021 @default.
- W2810204953 countsByYear W28102049532022 @default.
- W2810204953 countsByYear W28102049532023 @default.
- W2810204953 crossrefType "journal-article" @default.
- W2810204953 hasAuthorship W2810204953A5001293774 @default.
- W2810204953 hasAuthorship W2810204953A5003737733 @default.
- W2810204953 hasAuthorship W2810204953A5004167699 @default.
- W2810204953 hasAuthorship W2810204953A5004843806 @default.
- W2810204953 hasAuthorship W2810204953A5007540485 @default.
- W2810204953 hasAuthorship W2810204953A5008913656 @default.
- W2810204953 hasAuthorship W2810204953A5010468676 @default.
- W2810204953 hasAuthorship W2810204953A5022517973 @default.
- W2810204953 hasAuthorship W2810204953A5032916124 @default.
- W2810204953 hasAuthorship W2810204953A5058292733 @default.
- W2810204953 hasAuthorship W2810204953A5068368469 @default.
- W2810204953 hasAuthorship W2810204953A5071881588 @default.