FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810208259> ?p ?o ?g. }

• W2810208259 endingPage "1069" @default.
• W2810208259 startingPage "1061" @default.
• W2810208259 abstract "Background Cardiovascular risk factors (CVRFs) and endothelial dysfunction have been associated independently with poorer neurocognition in middle-aged adults, particularly on tests of frontal lobe function. However, to our knowledge, no studies have examined markers of microvascular dysfunction on neurocognition or the potential interaction between macro- and microvascular biomarkers on neurocognition in middle-aged and older adults with major depressive disorder (MDD). Methods Participants included 202 adults with MDD who were not receiving mental health treatment. Microvascular endothelial function was assessed using a noninvasive marker of forearm reactive hyperemia velocity while macrovascular endothelial function was assessed using flow-mediated dilation (FMD) of the brachial artery. CVRFs were assessed using the Framingham Stroke Risk Profile and fasting lipid levels. A standardized neurocognitive assessment battery was used to assess three cognitive domains: executive function, working memory, and verbal memory. Results Greater microvascular dysfunction was associated with poorer neurocognition across all three domains. Microvascular function continued to predict verbal memory performance after accounting for background factors and CVRFs. Macro- and microvascular function interacted to predict working memory performance (F = 4.511, 178, p = 0.035), with a similar nonsignificant association for executive function (F = 2.731, 178, p = 0.095), with moderate associations observed between microvascular function and neurocognition in the presence of preserved FMD (r61 = 0.40, p = 0.001), but not when FMD was impaired (r63 = −0.05, p = 0.675). Conclusion Greater microvascular dysfunction is associated with poorer neurocognition among middle-aged and older adults. This association was strongest in participants with preserved macrovascular function. Cardiovascular risk factors (CVRFs) and endothelial dysfunction have been associated independently with poorer neurocognition in middle-aged adults, particularly on tests of frontal lobe function. However, to our knowledge, no studies have examined markers of microvascular dysfunction on neurocognition or the potential interaction between macro- and microvascular biomarkers on neurocognition in middle-aged and older adults with major depressive disorder (MDD). Participants included 202 adults with MDD who were not receiving mental health treatment. Microvascular endothelial function was assessed using a noninvasive marker of forearm reactive hyperemia velocity while macrovascular endothelial function was assessed using flow-mediated dilation (FMD) of the brachial artery. CVRFs were assessed using the Framingham Stroke Risk Profile and fasting lipid levels. A standardized neurocognitive assessment battery was used to assess three cognitive domains: executive function, working memory, and verbal memory. Greater microvascular dysfunction was associated with poorer neurocognition across all three domains. Microvascular function continued to predict verbal memory performance after accounting for background factors and CVRFs. Macro- and microvascular function interacted to predict working memory performance (F = 4.511, 178, p = 0.035), with a similar nonsignificant association for executive function (F = 2.731, 178, p = 0.095), with moderate associations observed between microvascular function and neurocognition in the presence of preserved FMD (r61 = 0.40, p = 0.001), but not when FMD was impaired (r63 = −0.05, p = 0.675). Greater microvascular dysfunction is associated with poorer neurocognition among middle-aged and older adults. This association was strongest in participants with preserved macrovascular function." @default.
• W2810208259 created "2018-07-10" @default.
• W2810208259 creator A5006823361 @default.
• W2810208259 creator A5014216198 @default.
• W2810208259 creator A5054398235 @default.
• W2810208259 creator A5055611035 @default.
• W2810208259 creator A5072935545 @default.
• W2810208259 creator A5084066583 @default.
• W2810208259 date "2018-10-01" @default.
• W2810208259 modified "2023-09-26" @default.
• W2810208259 title "Microvascular Endothelial Function and Neurocognition Among Adults With Major Depressive Disorder" @default.
• W2810208259 cites W1147956078 @default.
• W2810208259 cites W1420581588 @default.
• W2810208259 cites W1838155304 @default.
• W2810208259 cites W1917842559 @default.
• W2810208259 cites W1967944820 @default.
• W2810208259 cites W1980650150 @default.
• W2810208259 cites W1992235145 @default.
• W2810208259 cites W2002062618 @default.
• W2810208259 cites W2014007645 @default.
• W2810208259 cites W2020449419 @default.
• W2810208259 cites W2023280641 @default.
• W2810208259 cites W2029269825 @default.
• W2810208259 cites W2030150154 @default.
• W2810208259 cites W2034863540 @default.
• W2810208259 cites W2036940388 @default.
• W2810208259 cites W2037406584 @default.
• W2810208259 cites W2070851857 @default.
• W2810208259 cites W2077264199 @default.
• W2810208259 cites W2105128106 @default.
• W2810208259 cites W2120357670 @default.
• W2810208259 cites W2122281432 @default.
• W2810208259 cites W2135954257 @default.
• W2810208259 cites W2136520115 @default.
• W2810208259 cites W2154166294 @default.
• W2810208259 cites W2159442683 @default.
• W2810208259 cites W2160504331 @default.
• W2810208259 cites W2168536722 @default.
• W2810208259 cites W2174294290 @default.
• W2810208259 cites W2225294096 @default.
• W2810208259 cites W2287005309 @default.
• W2810208259 cites W2293928055 @default.
• W2810208259 cites W2342034212 @default.
• W2810208259 cites W2405365167 @default.
• W2810208259 cites W2414006474 @default.
• W2810208259 cites W2416740112 @default.
• W2810208259 cites W2511684607 @default.
• W2810208259 cites W2527609605 @default.
• W2810208259 cites W2530115453 @default.
• W2810208259 cites W2531991917 @default.
• W2810208259 cites W2543174917 @default.
• W2810208259 cites W2552241218 @default.
• W2810208259 cites W2557919609 @default.
• W2810208259 cites W2620050029 @default.
• W2810208259 cites W2743952588 @default.
• W2810208259 cites W2790544524 @default.
• W2810208259 cites W2806973106 @default.
• W2810208259 doi "https://doi.org/10.1016/j.jagp.2018.06.011" @default.
• W2810208259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6165686" @default.
• W2810208259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30093218" @default.
• W2810208259 hasPublicationYear "2018" @default.
• W2810208259 type Work @default.
• W2810208259 sameAs 2810208259 @default.
• W2810208259 citedByCount "12" @default.
• W2810208259 countsByYear W28102082592019 @default.
• W2810208259 countsByYear W28102082592020 @default.
• W2810208259 countsByYear W28102082592021 @default.
• W2810208259 countsByYear W28102082592022 @default.
• W2810208259 countsByYear W28102082592023 @default.
• W2810208259 crossrefType "journal-article" @default.
• W2810208259 hasAuthorship W2810208259A5006823361 @default.
• W2810208259 hasAuthorship W2810208259A5014216198 @default.
• W2810208259 hasAuthorship W2810208259A5054398235 @default.
• W2810208259 hasAuthorship W2810208259A5055611035 @default.
• W2810208259 hasAuthorship W2810208259A5072935545 @default.
• W2810208259 hasAuthorship W2810208259A5084066583 @default.
• W2810208259 hasBestOaLocation W28102082591 @default.
• W2810208259 hasConcept C105641010 @default.
• W2810208259 hasConcept C118552586 @default.
• W2810208259 hasConcept C120770815 @default.
• W2810208259 hasConcept C126322002 @default.
• W2810208259 hasConcept C14216870 @default.
• W2810208259 hasConcept C15744967 @default.
• W2810208259 hasConcept C164705383 @default.
• W2810208259 hasConcept C169900460 @default.
• W2810208259 hasConcept C172467417 @default.
• W2810208259 hasConcept C2777604165 @default.
• W2810208259 hasConcept C2779985164 @default.
• W2810208259 hasConcept C2780972559 @default.
• W2810208259 hasConcept C3019128504 @default.
• W2810208259 hasConcept C71924100 @default.
• W2810208259 hasConcept C84393581 @default.
• W2810208259 hasConceptScore W2810208259C105641010 @default.
• W2810208259 hasConceptScore W2810208259C118552586 @default.
• W2810208259 hasConceptScore W2810208259C120770815 @default.
• W2810208259 hasConceptScore W2810208259C126322002 @default.
• W2810208259 hasConceptScore W2810208259C14216870 @default.
• W2810208259 hasConceptScore W2810208259C15744967 @default.

• next