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- W2810232209 abstract "The physiological consequences of COX-2 overexpression in the development of cancer, diabetes and neurodegenerative diseases have made this enzyme a promising therapeutic target. Herein, COX-2 active site was analyzed and new molecules were designed. We identified a highly potent molecule (S)-3a with IC50 value and the selectivity for COX-2 0.6 nM and 1666, respectively. The MTD of (S)-3a was 2000 mg kg-1 and its pharmacokinetic studies in rat showed t1/2 7.5 h. This compound reversed acetic acid induced analgesia and carragennan induced inflammation by 50% and 25% in rat when used at a dose 10 mg kg-1. Mechanistically, it was found that compound (S)-3a inhibits COX-2. Overall, the combination of physico-chemical and biological experiments facilitated the development of a new lead molecule to anti-inflammatory drug." @default.
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- W2810232209 date "2018-07-03" @default.
- W2810232209 modified "2023-09-27" @default.
- W2810232209 title "Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor" @default.
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- W2810232209 doi "https://doi.org/10.1038/s41598-018-28408-8" @default.
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