FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810248857> ?p ?o ?g. }

• W2810248857 abstract "The generation of abnormal excitations in pathological regions of the heart is a main trigger for lethal cardiac arrhythmias. Such abnormal excitations, also called ectopic activity, often arise from areas with local tissue heterogeneity or damage accompanied by localized depolarization. Finding the conditions that lead to ectopy is important to understand the basic biophysical principles underlying arrhythmia initiation and might further refine clinical procedures. In this study, we are the first to address the question of how geometry of the abnormal region affects the onset of ectopy using a combination of experimental, in silico, and theoretical approaches. We paradoxically find that, for any studied geometry of the depolarized region in optogenetically modified monolayers of cardiac cells, primary ectopic excitation originates at areas of maximal curvature of the boundary, where the stimulating electrotonic currents are minimal. It contradicts the standard critical nucleation theory applied to nonlinear waves in reaction-diffusion systems, where a higher stimulus is expected to produce excitation more easily. Our in silico studies reveal that the nonconventional ectopic activity is caused by an oscillatory instability at the boundary of the damaged region, the occurrence of which depends on the curvature of that boundary. The onset of this instability is confirmed using the Schrödinger equation methodology proposed by Rinzel and Keener [SIAM J. Appl. Math. 43, 907 (1983)]. Overall, we show distinctively novel insight into how the geometry of a heterogeneous cardiac region determines ectopic activity, which can be used in the future to predict the conditions that can trigger cardiac arrhythmias." @default.
• W2810248857 created "2018-07-10" @default.
• W2810248857 creator A5023533339 @default.
• W2810248857 creator A5023653576 @default.
• W2810248857 creator A5038258898 @default.
• W2810248857 creator A5039729276 @default.
• W2810248857 creator A5041678517 @default.
• W2810248857 date "2018-06-26" @default.
• W2810248857 modified "2023-09-26" @default.
• W2810248857 title "Paradoxical Onset of Arrhythmic Waves from Depolarized Areas in Cardiac Tissue Due to Curvature-Dependent Instability" @default.
• W2810248857 cites W1244547510 @default.
• W2810248857 cites W1490598572 @default.
• W2810248857 cites W1504775403 @default.
• W2810248857 cites W1945116108 @default.
• W2810248857 cites W1971867698 @default.
• W2810248857 cites W1974730466 @default.
• W2810248857 cites W1978605228 @default.
• W2810248857 cites W1981313051 @default.
• W2810248857 cites W1997279170 @default.
• W2810248857 cites W1998431529 @default.
• W2810248857 cites W2001594716 @default.
• W2810248857 cites W2004165374 @default.
• W2810248857 cites W2009375605 @default.
• W2810248857 cites W2013878893 @default.
• W2810248857 cites W2020501557 @default.
• W2810248857 cites W2021611778 @default.
• W2810248857 cites W2024588827 @default.
• W2810248857 cites W2027777648 @default.
• W2810248857 cites W2034119192 @default.
• W2810248857 cites W2038657224 @default.
• W2810248857 cites W2043571478 @default.
• W2810248857 cites W2044122402 @default.
• W2810248857 cites W2051392418 @default.
• W2810248857 cites W2051461374 @default.
• W2810248857 cites W2052580196 @default.
• W2810248857 cites W2057818365 @default.
• W2810248857 cites W2058585715 @default.
• W2810248857 cites W2061370052 @default.
• W2810248857 cites W2061451182 @default.
• W2810248857 cites W2063103281 @default.
• W2810248857 cites W2067598626 @default.
• W2810248857 cites W2080148075 @default.
• W2810248857 cites W2083706353 @default.
• W2810248857 cites W2087635067 @default.
• W2810248857 cites W2094037162 @default.
• W2810248857 cites W2112091653 @default.
• W2810248857 cites W2113420824 @default.
• W2810248857 cites W2115765852 @default.
• W2810248857 cites W2127854713 @default.
• W2810248857 cites W2130321115 @default.
• W2810248857 cites W2130680932 @default.
• W2810248857 cites W2153399593 @default.
• W2810248857 cites W2158054718 @default.
• W2810248857 cites W2167095271 @default.
• W2810248857 cites W2171154468 @default.
• W2810248857 cites W2315811111 @default.
• W2810248857 cites W2337942568 @default.
• W2810248857 cites W2460068949 @default.
• W2810248857 cites W2511327285 @default.
• W2810248857 cites W2528419909 @default.
• W2810248857 cites W2581271153 @default.
• W2810248857 cites W2589444478 @default.
• W2810248857 cites W3126080466 @default.
• W2810248857 cites W4214617048 @default.
• W2810248857 doi "https://doi.org/10.1103/physrevx.8.021077" @default.
• W2810248857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6130777" @default.
• W2810248857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30210937" @default.
• W2810248857 hasPublicationYear "2018" @default.
• W2810248857 type Work @default.
• W2810248857 sameAs 2810248857 @default.
• W2810248857 citedByCount "8" @default.
• W2810248857 countsByYear W28102488572019 @default.
• W2810248857 countsByYear W28102488572020 @default.
• W2810248857 countsByYear W28102488572021 @default.
• W2810248857 countsByYear W28102488572022 @default.
• W2810248857 countsByYear W28102488572023 @default.
• W2810248857 crossrefType "journal-article" @default.
• W2810248857 hasAuthorship W2810248857A5023533339 @default.
• W2810248857 hasAuthorship W2810248857A5023653576 @default.
• W2810248857 hasAuthorship W2810248857A5038258898 @default.
• W2810248857 hasAuthorship W2810248857A5039729276 @default.
• W2810248857 hasAuthorship W2810248857A5041678517 @default.
• W2810248857 hasBestOaLocation W28102488571 @default.
• W2810248857 hasConcept C104317684 @default.
• W2810248857 hasConcept C121332964 @default.
• W2810248857 hasConcept C126322002 @default.
• W2810248857 hasConcept C158622935 @default.
• W2810248857 hasConcept C185592680 @default.
• W2810248857 hasConcept C195065555 @default.
• W2810248857 hasConcept C207821765 @default.
• W2810248857 hasConcept C2524010 @default.
• W2810248857 hasConcept C2775905019 @default.
• W2810248857 hasConcept C33923547 @default.
• W2810248857 hasConcept C4141045 @default.
• W2810248857 hasConcept C55493867 @default.
• W2810248857 hasConcept C57879066 @default.
• W2810248857 hasConcept C62520636 @default.
• W2810248857 hasConcept C71924100 @default.
• W2810248857 hasConcept C83581075 @default.
• W2810248857 hasConceptScore W2810248857C104317684 @default.

• next