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• W2810270551 abstract "Intake of glucosinolates and risk of coronary heart disease in three large prospective cohorts of US men and women Le Ma,1,2 Gang Liu,1 Geng Zong,1 Laura Sampson,1 Frank B Hu,1,3,4 Walter C Willett,1,3,4 Eric B Rimm,1,3,4 JoAnn E Manson,3,5,6 Kathryn M Rexrode,6 Qi Sun1,4 1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; 2Department of Maternal, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China; 3Department of Epidemiology, Harvard T.H. Chan School of Public Health, 4Channing Division of Network Medicine, Department of Medicine, 5Department of Medicine, 6Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA Importance: Glucosinolates, a group of phytochemicals abundant in cruciferous vegetables, may have cardioprotective properties. However, no prospective study has evaluated the association of intake of glucosinolates with the risk of coronary heart disease (CHD).Objective: The objective of the study was to evaluate the association between the intake of glucosinolates and incident CHD in US men and women.Design: Prospective longitudinal cohort study.Setting: Health professionals in the USA.Participants: We followed 74,241 women in the Nurses’ Health Study (NHS; 1984–2012), 94,163 women in the NHSII (1991–2013), and 42,170 men in the Health Professionals Follow-Up Study (1986–2012), who were free of cardiovascular disease and cancer at baseline.Exposure: Glucosinolate intake was assessed using validated semi-quantitative food frequency questionnaires at baseline and updated every 2–4 years during follow-up.Main outcome measures: Incident cases of CHD were confirmed by medical record review.Results: During 4,824,001 person-years of follow-up, 8,010 cases of CHD were identified in the three cohorts. After adjustment for major lifestyle and dietary risk factors of CHD, weak but significantly positive associations were observed for glucosinolates with CHD risk when comparing the top with bottom quintiles (hazard ratio [HR]:1.09; 95% CI: 1.01, 1.17; Ptrend" @default.
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• W2810270551 date "2018-06-01" @default.
• W2810270551 modified "2023-09-25" @default.
• W2810270551 title "Intake of glucosinolates and risk of coronary heart disease in three large prospective cohorts of US men and women" @default.
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• W2810270551 doi "https://doi.org/10.2147/clep.s164497" @default.
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