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• W2810298578 abstract "Introduction: Frozen sections (FS) are routinely employed to assess margin status during partial nephrectomy (PN) for clinically localized renal cell carcinoma (CLRCC); however, their oncologic benefit remains unclear. There have been no studies investigating the long-term impact of FS on local or metastatic recurrence. We wished to determine whether the utilization of FS for this purpose during PN influenced recurrence rates. Materials and Methods: We performed a retrospective review of 1090 patients with (n = 172) and without (n = 918) FS during open and robotic PN between 2006 and 2016 for CLRCC at a single tertiary care institution. Standard follow-up protocols were employed, with imaging used to guide subsequent biopsy for confirmation. Univariate and multivariate competing-risk regression analysis predicting the association of FS status and clinicodemographic characteristics with recurrence, with adjustment for all-cause mortality, were performed. Administrative data were reviewed to calculate costs of FS. Results: Forty-five out of 1090 (4.13%) patients had recurrence. There was no difference in the cumulative incidence of recurrence between patients with and without FS (χ2 = 0.001, p = 0.97). On multivariable competing risk analysis, FS was not associated with recurrence (hazard ratio [HR], 1.56; 95% confidence interval [CI], 0.65–3.76). However, tumor grade (g3–4 vs 1–2: HR, 2.45; 95% CI, 1.16–5.14) and stage (>pT2 vs pT1a: HR, 2.86; 95% CI, 1.13–7.26) were associated with recurrence. The average direct charge per patient undergoing FS was $902. Conclusions: Intraoperative FS for margins during PN did not predict decreased recurrence rates in a single-institution high-volume center. Given the lack of associated benefit, and the added cost, the utilization of FS during PN should be limited." @default.
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• W2810298578 date "2018-08-01" @default.
• W2810298578 modified "2023-09-29" @default.
• W2810298578 title "Frozen Sections for Margins During Partial Nephrectomy Do Not Influence Recurrence Rates" @default.
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• W2810298578 doi "https://doi.org/10.1089/end.2018.0314" @default.
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