FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810324481> ?p ?o ?g. }

• W2810324481 endingPage "182" @default.
• W2810324481 startingPage "173" @default.
• W2810324481 abstract "Vasopressor agents could have certain specific effects in patients with cardiogenic shock (CS) after myocardial infarction, which may influence outcome. Although norepinephrine and epinephrine are currently the most commonly used agents, no randomized trial has compared their effects, and intervention data are lacking. The goal of this paper was to compare in a prospective, double-blind, multicenter, randomized study, the efficacy and safety of epinephrine and norepinephrine in patients with CS after acute myocardial infarction. The primary efficacy outcome was cardiac index evolution, and the primary safety outcome was the occurrence of refractory CS. Refractory CS was defined as CS with sustained hypotension, end-organ hypoperfusion and hyperlactatemia, and high inotrope and vasopressor doses. Fifty-seven patients were randomized into 2 study arms, epinephrine and norepinephrine. For the primary efficacy endpoint, cardiac index evolution was similar between the 2 groups (p = 0.43) from baseline (H0) to H72. For the main safety endpoint, the observed higher incidence of refractory shock in the epinephrine group (10 of 27 [37%] vs. norepinephrine 2 of 30 [7%]; p = 0.008) led to early termination of the study. Heart rate increased significantly with epinephrine from H2 to H24 while remaining unchanged with norepinephrine (p < 0.0001). Several metabolic changes were unfavorable to epinephrine compared with norepinephrine, including an increase in cardiac double product (p = 0.0002) and lactic acidosis from H2 to H24 (p < 0.0001). In patients with CS secondary to acute myocardial infarction, the use of epinephrine compared with norepinephrine was associated with similar effects on arterial pressure and cardiac index and a higher incidence of refractory shock. (Study Comparing the Efficacy and Tolerability of Epinephrine and Norepinephrine in Cardiogenic Shock [OptimaCC]; NCT01367743)" @default.
• W2810324481 created "2018-07-10" @default.
• W2810324481 creator A5001046858 @default.
• W2810324481 creator A5001143888 @default.
• W2810324481 creator A5007666743 @default.
• W2810324481 creator A5008530481 @default.
• W2810324481 creator A5021820774 @default.
• W2810324481 creator A5022515811 @default.
• W2810324481 creator A5022604095 @default.
• W2810324481 creator A5023559190 @default.
• W2810324481 creator A5023660228 @default.
• W2810324481 creator A5023731962 @default.
• W2810324481 creator A5026753394 @default.
• W2810324481 creator A5032594057 @default.
• W2810324481 creator A5033387857 @default.
• W2810324481 creator A5038644278 @default.
• W2810324481 creator A5042439215 @default.
• W2810324481 creator A5043883220 @default.
• W2810324481 creator A5044530681 @default.
• W2810324481 creator A5049555330 @default.
• W2810324481 creator A5053660166 @default.
• W2810324481 creator A5058830049 @default.
• W2810324481 creator A5065027400 @default.
• W2810324481 creator A5067526166 @default.
• W2810324481 creator A5072549111 @default.
• W2810324481 creator A5076475542 @default.
• W2810324481 creator A5076575252 @default.
• W2810324481 creator A5076735345 @default.
• W2810324481 creator A5078415435 @default.
• W2810324481 creator A5079600079 @default.
• W2810324481 creator A5080462509 @default.
• W2810324481 creator A5081791142 @default.
• W2810324481 creator A5082929901 @default.
• W2810324481 creator A5086344364 @default.
• W2810324481 creator A5088741568 @default.
• W2810324481 date "2018-07-01" @default.
• W2810324481 modified "2023-10-14" @default.
• W2810324481 title "Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction" @default.
• W2810324481 cites W1484146179 @default.
• W2810324481 cites W1810528900 @default.
• W2810324481 cites W1970024512 @default.
• W2810324481 cites W1995466640 @default.
• W2810324481 cites W2006710447 @default.
• W2810324481 cites W2009136076 @default.
• W2810324481 cites W2021000405 @default.
• W2810324481 cites W2023235203 @default.
• W2810324481 cites W2025411025 @default.
• W2810324481 cites W2029949452 @default.
• W2810324481 cites W2031379515 @default.
• W2810324481 cites W2053798407 @default.
• W2810324481 cites W2069431723 @default.
• W2810324481 cites W2095944485 @default.
• W2810324481 cites W2100366210 @default.
• W2810324481 cites W2106703370 @default.
• W2810324481 cites W2124596603 @default.
• W2810324481 cites W2132190220 @default.
• W2810324481 cites W2134256354 @default.
• W2810324481 cites W2143737878 @default.
• W2810324481 cites W2155322987 @default.
• W2810324481 cites W2159933802 @default.
• W2810324481 cites W2161803935 @default.
• W2810324481 cites W2287296216 @default.
• W2810324481 cites W2333493892 @default.
• W2810324481 cites W2472746779 @default.
• W2810324481 cites W2517170939 @default.
• W2810324481 cites W2540963844 @default.
• W2810324481 cites W2581164304 @default.
• W2810324481 cites W2754054868 @default.
• W2810324481 cites W2755584350 @default.
• W2810324481 cites W2766152280 @default.
• W2810324481 cites W2778669174 @default.
• W2810324481 cites W4205395603 @default.
• W2810324481 doi "https://doi.org/10.1016/j.jacc.2018.04.051" @default.
• W2810324481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29976291" @default.
• W2810324481 hasPublicationYear "2018" @default.
• W2810324481 type Work @default.
• W2810324481 sameAs 2810324481 @default.
• W2810324481 citedByCount "249" @default.
• W2810324481 countsByYear W28103244812018 @default.
• W2810324481 countsByYear W28103244812019 @default.
• W2810324481 countsByYear W28103244812020 @default.
• W2810324481 countsByYear W28103244812021 @default.
• W2810324481 countsByYear W28103244812022 @default.
• W2810324481 countsByYear W28103244812023 @default.
• W2810324481 crossrefType "journal-article" @default.
• W2810324481 hasAuthorship W2810324481A5001046858 @default.
• W2810324481 hasAuthorship W2810324481A5001143888 @default.
• W2810324481 hasAuthorship W2810324481A5007666743 @default.
• W2810324481 hasAuthorship W2810324481A5008530481 @default.
• W2810324481 hasAuthorship W2810324481A5021820774 @default.
• W2810324481 hasAuthorship W2810324481A5022515811 @default.
• W2810324481 hasAuthorship W2810324481A5022604095 @default.
• W2810324481 hasAuthorship W2810324481A5023559190 @default.
• W2810324481 hasAuthorship W2810324481A5023660228 @default.
• W2810324481 hasAuthorship W2810324481A5023731962 @default.
• W2810324481 hasAuthorship W2810324481A5026753394 @default.
• W2810324481 hasAuthorship W2810324481A5032594057 @default.
• W2810324481 hasAuthorship W2810324481A5033387857 @default.

• next