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- W2810330663 abstract "Multiple sclerosis (MS) is a debilitating inflammatory autoimmune disease with characteristic neuron demyelination and irreversible damage of neuronal axons and oligodendrocytes. This chapter discusses research lessons learnt from nanotherapeutic interventions for neurodegenerative disorders, as a potential approach forward for application in MS. Advanced drug delivery systems have shown encouraging success to negate these barriers, specifically as nanocomposites derived through various formulation techniques, resulting in nanoliposomes, stimuli-responsive polymeric systems, and inorganic/organic nanoparticles (NPs), which have been researched as promising carrier systems in MS treatment. These new approaches of NPs application are employed in two techniques; antiinflammatory and neuro-protection. Nanocomposite systems have demonstrated superior therapeutic efficacy, evaluated in either experimental autoimmune encephalomyelitis (EAE) or MS-induced animal models. This chapter therefore highlights most recent nanocomposite-driven drug delivery systems for therapeutic application in MS, and their significance compared to traditional nanostrategies, with a positive future outlook employing nanocomposite designs." @default.
- W2810330663 created "2018-07-10" @default.
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- W2810330663 date "2018-01-01" @default.
- W2810330663 modified "2023-10-13" @default.
- W2810330663 title "Nanocomposites for therapeutic application in multiple sclerosis" @default.
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- W2810330663 doi "https://doi.org/10.1016/b978-0-12-813741-3.00017-0" @default.
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