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• W2810332204 abstract "Abstract The timing of initiation of continuous renal replacement therapy (CRRT) for critically ill patients remains uncertain. The ideal circumstances for when to initiate CRRT remains an important unanswered question and is currently a high research priority in the field of critical care nephrology. Among patients faced with life-threatening complications of acute kidney injury (AKI), such as severe hyperkalemia, marked metabolic acidosis, uremia, and/or fluid overload, the decision to urgently start CRRT is generally unequivocal. However, the occurrence of life-threatening complications attributable to AKI has less commonly become a trigger for starting CRRT in intensive care unit settings. Indeed, in the absence of overt or impending life-threatening complications, the optimal time to start CRRT is unknown. Similarly, few studies have evaluated the optimal circumstances for when and how to wean or discontinue patients from CRRT. Not surprisingly, given this knowledge gap, there is wide variation in clinical practice for the timing for starting and discontinuation of CRRT. This practice of heterogeneity, driven partly by gaps in evidence to guide practice, contributes to suboptimal quality of care." @default.
• W2810332204 created "2018-07-10" @default.
• W2810332204 creator A5035704791 @default.
• W2810332204 creator A5036301763 @default.
• W2810332204 date "2019-01-01" @default.
• W2810332204 modified "2023-10-16" @default.
• W2810332204 title "Beginning and Ending Continuous Renal Replacement Therapy in the Intensive Care Unit" @default.
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• W2810332204 doi "https://doi.org/10.1016/b978-0-323-44942-7.00164-3" @default.
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