Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810337145> ?p ?o ?g. }
- W2810337145 abstract "Abstract Cancer evolves through a multistep process that occurs by the temporal accumulation of genetic mutations mediated by intracellular and extracellular cues. We observe that exosomes isolated from pancreatic cancer cells, but not normal pancreatic cells, can initiate the first step of malignant cell transformation. Injection of exosome-initiated transformed cells into mice results in aggressive tumor growth. Using proteomic profiling and DNA sequencing of exosome-treated and transformed cells, we show that cancer cell exosomes act as a classic initiator by causing random genetic changes in recipient cells. Our studies provide new insight into a function of cancer cell exosomes and how they might specifically contribute to orchestrated local cell transformation. One Sentence Summary Exosomes function as an initiator of tumor formation." @default.
- W2810337145 created "2018-07-10" @default.
- W2810337145 creator A5010965998 @default.
- W2810337145 creator A5021242652 @default.
- W2810337145 creator A5030213423 @default.
- W2810337145 creator A5031757607 @default.
- W2810337145 creator A5043593028 @default.
- W2810337145 creator A5052782883 @default.
- W2810337145 creator A5059160890 @default.
- W2810337145 creator A5078146610 @default.
- W2810337145 creator A5079655099 @default.
- W2810337145 date "2018-07-03" @default.
- W2810337145 modified "2023-09-27" @default.
- W2810337145 title "Cancer cell exosomes can initiate malignant cell transformation" @default.
- W2810337145 cites W1601681275 @default.
- W2810337145 cites W1661741909 @default.
- W2810337145 cites W1832220924 @default.
- W2810337145 cites W1969607893 @default.
- W2810337145 cites W1974029473 @default.
- W2810337145 cites W1975023230 @default.
- W2810337145 cites W1992508309 @default.
- W2810337145 cites W1997348397 @default.
- W2810337145 cites W2044108714 @default.
- W2810337145 cites W2055875511 @default.
- W2810337145 cites W2066328344 @default.
- W2810337145 cites W2078554949 @default.
- W2810337145 cites W2084770914 @default.
- W2810337145 cites W2087761358 @default.
- W2810337145 cites W2098259366 @default.
- W2810337145 cites W2103441770 @default.
- W2810337145 cites W2109564400 @default.
- W2810337145 cites W2159401023 @default.
- W2810337145 cites W2161633633 @default.
- W2810337145 cites W2169465106 @default.
- W2810337145 cites W2175297783 @default.
- W2810337145 cites W2195965780 @default.
- W2810337145 cites W2259481044 @default.
- W2810337145 cites W2288512038 @default.
- W2810337145 cites W2318433546 @default.
- W2810337145 cites W2567453627 @default.
- W2810337145 cites W2605556350 @default.
- W2810337145 cites W2607481912 @default.
- W2810337145 cites W2611549356 @default.
- W2810337145 cites W2734466041 @default.
- W2810337145 cites W2738491178 @default.
- W2810337145 cites W2760673044 @default.
- W2810337145 cites W2769100785 @default.
- W2810337145 cites W2792209856 @default.
- W2810337145 cites W2804368141 @default.
- W2810337145 cites W4248660331 @default.
- W2810337145 doi "https://doi.org/10.1101/360982" @default.
- W2810337145 hasPublicationYear "2018" @default.
- W2810337145 type Work @default.
- W2810337145 sameAs 2810337145 @default.
- W2810337145 citedByCount "0" @default.
- W2810337145 crossrefType "posted-content" @default.
- W2810337145 hasAuthorship W2810337145A5010965998 @default.
- W2810337145 hasAuthorship W2810337145A5021242652 @default.
- W2810337145 hasAuthorship W2810337145A5030213423 @default.
- W2810337145 hasAuthorship W2810337145A5031757607 @default.
- W2810337145 hasAuthorship W2810337145A5043593028 @default.
- W2810337145 hasAuthorship W2810337145A5052782883 @default.
- W2810337145 hasAuthorship W2810337145A5059160890 @default.
- W2810337145 hasAuthorship W2810337145A5078146610 @default.
- W2810337145 hasAuthorship W2810337145A5079655099 @default.
- W2810337145 hasBestOaLocation W28103371451 @default.
- W2810337145 hasConcept C104317684 @default.
- W2810337145 hasConcept C121608353 @default.
- W2810337145 hasConcept C145059251 @default.
- W2810337145 hasConcept C1491633281 @default.
- W2810337145 hasConcept C185592680 @default.
- W2810337145 hasConcept C204241405 @default.
- W2810337145 hasConcept C20518536 @default.
- W2810337145 hasConcept C2780210213 @default.
- W2810337145 hasConcept C2781261824 @default.
- W2810337145 hasConcept C28406088 @default.
- W2810337145 hasConcept C31033888 @default.
- W2810337145 hasConcept C502942594 @default.
- W2810337145 hasConcept C54355233 @default.
- W2810337145 hasConcept C79879829 @default.
- W2810337145 hasConcept C86803240 @default.
- W2810337145 hasConcept C95444343 @default.
- W2810337145 hasConcept C96232424 @default.
- W2810337145 hasConceptScore W2810337145C104317684 @default.
- W2810337145 hasConceptScore W2810337145C121608353 @default.
- W2810337145 hasConceptScore W2810337145C145059251 @default.
- W2810337145 hasConceptScore W2810337145C1491633281 @default.
- W2810337145 hasConceptScore W2810337145C185592680 @default.
- W2810337145 hasConceptScore W2810337145C204241405 @default.
- W2810337145 hasConceptScore W2810337145C20518536 @default.
- W2810337145 hasConceptScore W2810337145C2780210213 @default.
- W2810337145 hasConceptScore W2810337145C2781261824 @default.
- W2810337145 hasConceptScore W2810337145C28406088 @default.
- W2810337145 hasConceptScore W2810337145C31033888 @default.
- W2810337145 hasConceptScore W2810337145C502942594 @default.
- W2810337145 hasConceptScore W2810337145C54355233 @default.
- W2810337145 hasConceptScore W2810337145C79879829 @default.
- W2810337145 hasConceptScore W2810337145C86803240 @default.
- W2810337145 hasConceptScore W2810337145C95444343 @default.
- W2810337145 hasConceptScore W2810337145C96232424 @default.